膀胱癌患者中的 ERCC1 rs11615 单核苷酸多态性与顺铂化疗的安全性结果

Khaled Kotb, Moetaza Soliman, Amira Awadallah, Asmaa Ahmed, Hassan Abol-Enein, Mohamed Shams
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引用次数: 0

摘要

目的 探讨切除修复交叉补体组 1(ERCC1)rs11615 的单核苷酸多态性(SNP)与切除术后膀胱癌患者顺铂辅助化疗的安全性结果之间的关系。方法 这项试验性单中心回顾性队列研究涉及埃及曼苏拉大学泌尿学和肾脏病中心(UNC)在 2016 年 1 月至 12 月期间收治的 25 名肌浸润性膀胱癌患者。研究试图揭示ERCC1基因中的SNP rs11615与中位随访96周后血液、肾脏和肝脏生化指标从基线特征变化之间的关联。结果 对 rs11615 与化疗后尿酸和血红蛋白水平变化之间的关联进行单变量分析,结果显示两者之间存在统计学意义上的显著关系。结论 这些发现提示了基因对化疗反应的可能影响,需要进一步研究以了解其机制和潜在的临床意义。这将有助于制定个性化治疗方案,改善患者护理和治疗效果。
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ERCC1 rs11615 Single Nucleotide Polymorphism in Bladder Cancer Patients and Safety Outcomes of Cisplatin-Based Chemotherapy
Objectives To investigate the relationship between single nucleotide polymorphism (SNP) of excision repair cross-complementation group 1 (ERCC1) rs11615 and the safety outcomes of cisplatin-based adjuvant chemotherapy in post-cystectomy bladder cancer patients. Methods This pilot single-center retrospective cohort research study involved 25 patients with muscle-invasive bladder cancer who were admitted to the Urology and Nephrology Center (UNC), Mansoura University, Egypt between January and December 2016. The study tried to reveal the association between SNP rs11615 in ERCC1 gene and the change from baseline characteristics in a median of 96 weeks follow-up in blood, renal, and hepatic biochemical parameters. Results Univariate analysis of the association between rs11615 and post-chemotherapy changes in uric acid and hemoglobin levels showed a statistically significant relationship. Conclusion These findings hint at possible genetic influences in response to chemotherapy, necessitating further research to understand the mechanisms and potential clinical implications. This could lead to personalized treatment plans enhancing patient care and outcomes.
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