马齿苋叶提取物纳米喷雾制剂作为防晒剂的配方

Elmiawati Latifah
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引用次数: 0

摘要

马齿苋(Portulaca oleracea L.)是一种生长茂盛的野生植物,但其功效却鲜为人知。马齿苋含有皂甙,具有很高的抗氧化性和生物活性。对阳光照射敏感的皮肤正是这种纳米喷雾剂所针对的问题。本研究的目的是确定含有马齿苋防晒剂的中草药纳米喷雾产品的最佳配方,以治疗日晒引起的皮肤问题。采用的研究方法是实验法,研究阶段从植物确定、提取物制作、纳米喷雾配方确定、制剂评估、体内紫外线防护活性测试和体外 SPF 测试开始。使用 Microsoft Excel 和 SPSS Version 24 进行了定量描述性分析。4 个处理组之间的红斑(皮肤上的病变)存在明显差异,阴性对照组和阳性对照组以及给予 0.8 克和 0.4 克马齿苋提取物剂量处理(纳米颗粒中的提取物量)的组与阴性对照组之间存在明显差异。因此,可以得出结论,0.8 克(SPF 值:9.9)和 0.4 克(SPF 值:8.43)的马齿苋提取物有可能成为具有最大类别和额外保护能力的防晒剂。马齿苋提取物纳米喷雾防晒剂的优点是由草本成分制成,与化学防晒产品相比,刺激性较小。
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Formulation of nano spray preparation from Purslane Leaf Extract (Portulaca oleracea l.) as sunscreen
Purslane plant (Portulaca oleracea L.) is a type of wild plant that grows abundantly, but its benefits are rarely known. Purslane contains saponins, which have high antioxidant and biological activity. Skin that is sensitive to sun exposure is the issue this nanospray is targeting. The aim of this research is to determine the optimal formulation of herbal nanospray products with Purslane sunscreen to treat skin problems caused by sun exposure. The research method used was an experimental method with research stages starting from plant determination, extract making, nanospray formulation determination, preparation evaluation, in vivo UV protection activity test, and in vitro SPF test. Quantitative descriptive analysis was carried out using Microsoft Excel and SPSS Version 24. There were significant differences in erythema (lesions on the skin) between the 4 treatment groups, with significant differences in the negative control and positive control groups, as well as the group given dose treatment (the amount of extract in the nanoparticles) of 0.8 g and 0.4 g of purslane extract with the negative control. So, it can be concluded that doses of 0.8 g (SPF value: 9.9) and 0.4 g (SPF value: 8.43) of purslane extract have the potential to be sunscreens with maximum category and extra protective power. Purslane extract nanospray sunscreen has the advantage of being made from herbal ingredients, which have less potential for irritation than chemical sunscreen products.
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