Tekrarlayan İdrar Yolu Enfeksiyonlarında Etyolojik Modeller ve Antibiyotik Direnci

Abstract: Aim: Recurrent urinary tract infections (rUTIs) pose a significant clinical challenge due to their high prevalence and the escalating issue of antibiotic resistance. Understanding the etiological patterns and risk factors associated with rUTIs is crucial for effective management and prevention strategies. Escherichia coli is a prevalent pathogen in UTIs, but its emerging antibiotic resistance is a growing concern. This study aims to retrospectively analyze the prevalence of E. coli and patterns of antibiotic resistance in rUTIs. Material and Methods: Conducted at Özel Kızılay Kağıthane Hospital between 2020 and 2023, this retrospective cohort study included 265 patients diagnosed with rUTIs. Data encompassed demographics, clinical history, uropathogens, and antibiotic resistance patterns, offering insights into the etiology and resistance trends in this population. Results: Escherichia coli emerged as the main uropathogen in 70.6% of rUTI cases, with a significant proportion showing resistance to cotrimoxazole (54.5%) and fluoroquinolones (46.5%). The study predominantly involved female patients (79.2%), with sexual activity noted as a notable risk factor in 60% of these cases. Additionally, 40% of patients experienced moderate to severe symptoms, impacting their quality of life. Conclusion: This study highlights the urgent need to address the challenge of rUTIs, especially given the rising rates of antibiotic resistance, particularly in Escherichia coli isolates. It emphasizes the importance of considering patient demographics and risk factors in managing rUTIs. Future research, including prospective studies, is essential for developing effective therapeutic and preventive strategies to mitigate the burden of rUTIs on individuals and healthcare systems.