{"title":"改进肺癌肿瘤热消融过程中的温度演变模型","authors":"M. Selmi","doi":"10.3390/physics6010012","DOIUrl":null,"url":null,"abstract":"Microwave ablation (MWA) represents one of the most powerful tools in cancer treatment. This therapeutic modality process is governed by the temperature and absorbed dose of radiation of the cell tissue. This study was performed to control the temperature effect using simulation during the MWA thermal damage of lung tumor. For this reason, a two-dimensional (2D) computational modeling generated for adaptive lung tissue was designed and analyzed using the finite element method (FEM). Different approaches, such as first-order Arrhenius rate equations, Maxwell equations, and the bioheat equation, have been used to simulate necrosis in cells. To control the heat, a proportional–integral–derivative (PID) controller was used to moderate the input microwave power source and to maintain the temperature of the target tip at a lower level of the initial temperature data. Furthermore, full cancer tissue necrosis was also evaluated by processing time and thermal damage fraction. The obtained data proved that the target tip temperature was affected by the temperature distribution and specific absorption rate (SAR). However, a specific treatment period of tumor ablation is required to control and decrease the damage of surrounding healthy tissue to ensure a safe operation without any risk.","PeriodicalId":509432,"journal":{"name":"Physics","volume":"467 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation\",\"authors\":\"M. Selmi\",\"doi\":\"10.3390/physics6010012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Microwave ablation (MWA) represents one of the most powerful tools in cancer treatment. This therapeutic modality process is governed by the temperature and absorbed dose of radiation of the cell tissue. This study was performed to control the temperature effect using simulation during the MWA thermal damage of lung tumor. For this reason, a two-dimensional (2D) computational modeling generated for adaptive lung tissue was designed and analyzed using the finite element method (FEM). Different approaches, such as first-order Arrhenius rate equations, Maxwell equations, and the bioheat equation, have been used to simulate necrosis in cells. To control the heat, a proportional–integral–derivative (PID) controller was used to moderate the input microwave power source and to maintain the temperature of the target tip at a lower level of the initial temperature data. Furthermore, full cancer tissue necrosis was also evaluated by processing time and thermal damage fraction. The obtained data proved that the target tip temperature was affected by the temperature distribution and specific absorption rate (SAR). However, a specific treatment period of tumor ablation is required to control and decrease the damage of surrounding healthy tissue to ensure a safe operation without any risk.\",\"PeriodicalId\":509432,\"journal\":{\"name\":\"Physics\",\"volume\":\"467 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/physics6010012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/physics6010012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
微波消融(MWA)是治疗癌症的最有力工具之一。这种治疗方式的过程受细胞组织的温度和辐射吸收剂量的影响。本研究旨在通过模拟 MWA 对肺部肿瘤的热损伤来控制温度效应。为此,我们设计并使用有限元法(FEM)分析了为自适应肺组织生成的二维(2D)计算模型。一阶阿伦尼乌斯速率方程、麦克斯韦方程和生物热方程等不同方法已被用于模拟细胞坏死。为了控制热量,使用了一个比例-积分-派生(PID)控制器来调节输入微波功率源,并将目标尖端的温度维持在初始温度数据的较低水平。此外,还通过处理时间和热损伤率评估了癌组织的完全坏死情况。所得数据证明,靶尖温度受温度分布和比吸收率(SAR)的影响。然而,肿瘤消融需要一个特定的治疗时间,以控制和减少对周围健康组织的损伤,确保手术安全无风险。
Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation
Microwave ablation (MWA) represents one of the most powerful tools in cancer treatment. This therapeutic modality process is governed by the temperature and absorbed dose of radiation of the cell tissue. This study was performed to control the temperature effect using simulation during the MWA thermal damage of lung tumor. For this reason, a two-dimensional (2D) computational modeling generated for adaptive lung tissue was designed and analyzed using the finite element method (FEM). Different approaches, such as first-order Arrhenius rate equations, Maxwell equations, and the bioheat equation, have been used to simulate necrosis in cells. To control the heat, a proportional–integral–derivative (PID) controller was used to moderate the input microwave power source and to maintain the temperature of the target tip at a lower level of the initial temperature data. Furthermore, full cancer tissue necrosis was also evaluated by processing time and thermal damage fraction. The obtained data proved that the target tip temperature was affected by the temperature distribution and specific absorption rate (SAR). However, a specific treatment period of tumor ablation is required to control and decrease the damage of surrounding healthy tissue to ensure a safe operation without any risk.