中枢神经系统缺氧缺血性损伤导致的癫痫发作

T. V. Sorokovikova, A. Morozov, K. Aleksanyan, Yu. I. Kovalchuk, V. V. Frolova
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引用次数: 0

摘要

癫痫是一种慢性脑部疾病。这种疾病有许多危险因素和诱因,但众所周知,发病高峰出现在儿童出生后的第一年。这是因为在大多数情况下,这种病症是围产期对中枢神经系统(CNS)造成损伤的结果,而中枢神经系统的损伤是缺氧缺血性的。缺氧时出现的血流动力学紊乱会导致各种新陈代谢变化,随后伴随着神经元损伤和对所有过程的抑制作用减弱。在分析文献资料的基础上,我们研究了这种疾病的发病机制、病程特点以及缺氧缺血性中枢神经系统病变引起的癫痫发作的鉴别诊断特征。
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Epileptic seizures caused by hypoxic-ischemic damage to the central nervous system
Epilepsy is a chronic disease of the brain. There are many risk factors and causes of this disease, but it is known that the peak incidence occurs in the first year of a child's life. This is due to the fact that this pathology in most cases is the outcome of perinatal damage to the central nervous system (CNS), which has a hypoxic-ischemic genesis. Hemodynamic disturbances that occur in hypoxia lead to various metabolic shifts, which is subsequently accompanied by neuronal damage and reduced inhibitory influence over all processes. Based on the analysis of literature data, we studied the mechanisms of development of this disease, peculiarities of its course, and differential diagnostic features of epileptic seizures caused by hypoxic-ischemic CNS lesions.
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