{"title":"用 rp-hplc 法估测散装或制剂中的阿伐那非的简便、经济、稳定的指示方法","authors":"Pankaj Kadwe, D. Basedia, V. Thakur, B. K. Dubey","doi":"10.38164/ajper/13.1.2024.39-49","DOIUrl":null,"url":null,"abstract":"This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":"10 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SIMPLE COST-EFFECTIVE STABILITY INDICATING METHOD FOR THE ESTIMATION OF AVANAFIL IN BULK OR FORMULATION BY RP-HPLC\",\"authors\":\"Pankaj Kadwe, D. Basedia, V. Thakur, B. K. Dubey\",\"doi\":\"10.38164/ajper/13.1.2024.39-49\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.\",\"PeriodicalId\":8533,\"journal\":{\"name\":\"Asian Journal of Pharmaceutical Education and Research\",\"volume\":\"10 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Pharmaceutical Education and Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.38164/ajper/13.1.2024.39-49\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical Education and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.38164/ajper/13.1.2024.39-49","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SIMPLE COST-EFFECTIVE STABILITY INDICATING METHOD FOR THE ESTIMATION OF AVANAFIL IN BULK OR FORMULATION BY RP-HPLC
This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.
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