利用尿素、硫脲和 KOH 的新型深共晶溶剂混合物快速获得苯妥英和硫苯妥英的新方法

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC Chemistry of Heterocyclic Compounds Pub Date : 2024-04-08 DOI:10.1007/s10593-024-03300-8

Elena V. Khovrenko, Vadim Yu. Baula, Viktoria V. Shtrykova, Vera Yu. Kuksenok, Victor D. Filimonov

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引用次数: 0

摘要

尿素和硫脲在一定比例下与 KOH 形成相对稳定的液态深度共晶混合物。这些混合物在与苯并芘的反应中表现出很高的活性，能快速生成高产率的海因和硫代海因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A novel facile approach to obtain phenytoin and thiophenytoin using new deep eutectic solvent-like mixtures of urea, thiourea, and KOH

Urea and thiourea formed relatively stable liquid deep eutectic mixtures with KOH at certain ratios. These mixtures showed high activity in the reaction with benzils, quickly forming hydantoins and thiohydantoins in high yields.

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来源期刊

Chemistry of Heterocyclic Compounds 化学-有机化学

CiteScore

2.90

自引率

13.30%

发文量

审稿时长

1 months

期刊介绍： The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemoratives dedicated to prominent heterocyclic chemists.