通过光热驱动大孔硅膜中的 pNIPAAm 水凝胶刷实现局部流量控制

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2024-04-04 DOI:10.1007/s10404-024-02726-y
Youngsik Song, Nafis Mustakim, Mayank Pandey, Sang-Woo Seo
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引用次数: 0

摘要

我们介绍了如何通过大孔硅膜中的阵列微米级孔隙控制液体流动。孔隙表面涂有约 150 nm 的聚合物 N-异丙基丙烯酰胺(pNIPAAm)水凝胶刷和 200 nm 的聚吡咯层,聚吡咯层可用作光热致动器。利用对温度敏感的 pNIPAAm 刷子的膨胀和消肿行为来控制孔隙的大小,并通过向聚吡咯光热元件层照射 815 纳米的近红外(NIR)光来改变 pNIPAAm 刷子上的温度。在改变环境温度的同时,通过观察透过膜孔的透射光和荧光信号强度,研究了孔开口尺寸的变化。结果表明,透射光的强度可以通过调整环境温度来控制,使其跨越水凝胶刷的低临界溶液温度(LCST)。利用脉冲近红外光照明,荧光素染料从膜底部扩散到膜表面,证明了对液体流经孔隙的局部控制。荧光素染料扩散在近红外光照射下的快速动态响应表明,所提出的光热致动方法可应用于多种生物医学领域,如局部药物释放系统。
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Localized flow control by photothermal actuation of pNIPAAm hydrogel brushes in a macroporous silicon membrane

We present the control of liquid flow through arrayed micron-sized pores in a macroporous silicon membrane. The pores are coated with about 150 nm polymer N-isopropylacrylamide (pNIPAAm) hydrogel brushes and 200 nm polypyrrole layer, which works as photothermal actuator. The size of pore openings is controlled by utilizing the swelling and de-swelling behavior of temperature-sensitive pNIPAAm brushes, and the temperature on pNIPAAm brushes is changed by 815 nm near infra-red (NIR) illumination to polypyrrole photothermal element layer. The dimension change of the pore openings is investigated by observing the transmitted light and fluorescence signal intensity through the pores in the membrane while changing the ambient temperature. It has shown that the intensity of transmitted light can be controlled by adjusting the ambient temperature across the low critical solution temperature (LCST) of the hydrogel brushes. The localized control of liquid flow through the pores is demonstrated by the diffusion of fluorescein dye from the bottom of the membrane to the surface of the membrane using pulsed NIR light illumination. Fast dynamic response of fluorescein dye diffusion upon the illumination of NIR light suggests that the presented photothermal actuation approach could be applied to diverse biomedical applications such as a localized drug release system.

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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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