使用大麻对 HIV 感染者认知能力的影响:来自临床和临床前研究的功能依赖效应和机制证据

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2024-04-11 DOI:10.1007/s11904-024-00698-w
Samantha M. Ayoub, Breanna M. Holloway, Alannah H. Miranda, Benjamin Z. Roberts, Jared W. Young, Arpi Minassian, Ronald J. Ellis
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引用次数: 0

摘要

综述目的大麻可能对艾滋病病毒感染者(PWH)具有有益的抗炎作用;然而,鉴于这一人群的持续神经认知障碍(NCI)负担较高,临床医生担心他们可能特别容易受到大麻对认知的有害影响。在此,我们对评估大麻素暴露对 HIV 认知影响的临床和临床前研究进行了系统的范围界定综述。最新研究结果研究结果显示,几乎没有证据支持使用大麻会对 HIV 的认知产生有害影响,符合条件的临床前数据也很少。此外,所观察到的使用大麻对认知的有益/有害影响与功能有关,并受多种因素(如年龄、使用频率)的影响。摘要研究结果与大麻对艾滋病认知的潜在影响机制(如抗炎)一起进行了讨论,并概述了筛选可能受益于大麻干预的艾滋病感染者的注意事项。我们进一步强调了通过利用可转化的跨物种任务来促进人类和动物工作之间的比较,从而加快该领域研究发现的价值。
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The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies

Purpose of Review

Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.

Recent Findings

Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use).

Summary

Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.

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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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