利用针刺工艺低成本、便捷地制造聚合物微孔/纳米孔,并将其应用于纳米流体传感领域

IF 2.6 4区 工程技术 Q2 BIOCHEMICAL RESEARCH METHODS Biomicrofluidics Pub Date : 2024-04-01 DOI:10.1063/5.0203512
Rui Liu, Zhe Liu, Jianfeng Li, Yinghua Qiu
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引用次数: 0

摘要

固态微/纳米孔具有高稳定性和尺寸可控性,在传感领域发挥着重要作用。针对微孔制造工艺复杂、成本高的问题,我们提出了一种基于针刺法的便捷、低成本的微/纳米孔制造技术。通过控制微尺度钨针的进给量来刺穿薄膜,并通过电流反馈系统监测微孔的尺寸变化。基于微孔尺寸与电流阈值之间的正相关性,实现了微孔尺寸可控的制备。纳米孔的制备是通过针刺和化学蚀刻相结合的方法实现的。首先,用钨针在薄膜上制备锥形缺陷。然后,通过对薄膜进行单侧化学蚀刻获得纳米孔。利用制备的锥形微孔,可以对纳米粒子进行电阻脉冲检测。我们的锥形纳米孔还获得了显著的离子电流整流效果。事实证明,用我们的方法制备的微孔/纳米孔的性能与用轨迹蚀刻法制备的微孔/纳米孔的性能相当。本文提出的简单可控的制备工艺将推动低成本微孔/纳米孔传感器的发展。
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Low-cost and convenient fabrication of polymer micro/nanopores with the needle punching process and their applications in nanofluidic sensing
Solid-state micro/nanopores play an important role in the sensing field because of their high stability and controllable size. Aiming at problems of complex processes and high costs in pore manufacturing, we propose a convenient and low-cost micro/nanopore fabrication technique based on the needle punching method. The thin film is pierced by controlling the feed of a microscale tungsten needle, and the size variations of the micropore are monitored by the current feedback system. Based on the positive correlation between the micropore size and the current threshold, the size-controllable preparation of micropores is achieved. The preparation of nanopores is realized by the combination of needle punching and chemical etching. First, a conical defect is prepared on the film with the tungsten needle. Then, nanopores are obtained by unilateral chemical etching of the film. Using the prepared conical micropores, resistive-pulse detection of nanoparticles is performed. Significant ionic current rectification is also obtained with our conical nanopores. It is proved that the properties of micro/nanopores prepared by our method are comparable to those prepared by the track-etching method. The simple and controllable fabrication process proposed here will advance the development of low-cost micro/nanopore sensors.
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来源期刊
Biomicrofluidics
Biomicrofluidics 生物-纳米科技
CiteScore
5.80
自引率
3.10%
发文量
68
审稿时长
1.3 months
期刊介绍: Biomicrofluidics (BMF) is an online-only journal published by AIP Publishing to rapidly disseminate research in fundamental physicochemical mechanisms associated with microfluidic and nanofluidic phenomena. BMF also publishes research in unique microfluidic and nanofluidic techniques for diagnostic, medical, biological, pharmaceutical, environmental, and chemical applications. BMF offers quick publication, multimedia capability, and worldwide circulation among academic, national, and industrial laboratories. With a primary focus on high-quality original research articles, BMF also organizes special sections that help explain and define specific challenges unique to the interdisciplinary field of biomicrofluidics. Microfluidic and nanofluidic actuation (electrokinetics, acoustofluidics, optofluidics, capillary) Liquid Biopsy (microRNA profiling, circulating tumor cell isolation, exosome isolation, circulating tumor DNA quantification) Cell sorting, manipulation, and transfection (di/electrophoresis, magnetic beads, optical traps, electroporation) Molecular Separation and Concentration (isotachophoresis, concentration polarization, di/electrophoresis, magnetic beads, nanoparticles) Cell culture and analysis(single cell assays, stimuli response, stem cell transfection) Genomic and proteomic analysis (rapid gene sequencing, DNA/protein/carbohydrate arrays) Biosensors (immuno-assay, nucleic acid fluorescent assay, colorimetric assay, enzyme amplification, plasmonic and Raman nano-reporter, molecular beacon, FRET, aptamer, nanopore, optical fibers) Biophysical transport and characterization (DNA, single protein, ion channel and membrane dynamics, cell motility and communication mechanisms, electrophysiology, patch clamping). Etc...
期刊最新文献
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