纳米材料辅助溶瘤菌在实体瘤诊断和治疗中的应用

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL Bioengineering & Translational Medicine Pub Date : 2024-04-17 DOI:10.1002/btm2.10672
Xiangdi Zeng, Qi Chen, Tingtao Chen
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引用次数: 0

摘要

由于肿瘤内的异质性和动态的微环境,癌症给现代医学带来了严峻的挑战。天然或基因工程溶瘤菌因其内在的肿瘤靶向性和溶瘤能力一直受到科学家们的青睐。然而,免疫原性和低毒性不可避免地限制了它们在临床实践中的应用。当具有独特理化特性的纳米材料与溶瘤细菌结合在一起时,就能实现优势互补,构建高效安全的纳米生物混合物。在这篇综述中,我们首先分析了传统肿瘤治疗方法的优缺点,然后详细研究了溶瘤细菌所采用的精确溶瘤机制。随后,我们重点探讨利用纳米材料辅助溶瘤菌(NAOB)增强肿瘤治疗效果,并将其作为纳米otheranostic剂用于成像引导的肿瘤治疗。最后,本综述通过总结和分析目前纳米溶菌的不足之处,为开发纳米生物混合物提供了一些创新方向,旨在为实体瘤治疗领域注入新的研究理念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nanomaterial-assisted oncolytic bacteria in solid tumor diagnosis and therapeutics

Cancer presents a formidable challenge in modern medicine due to the intratumoral heterogeneity and the dynamic microenvironmental niche. Natural or genetically engineered oncolytic bacteria have always been hailed by scientists for their intrinsic tumor-targeting and oncolytic capacities. However, the immunogenicity and low toxicity inevitably constrain their application in clinical practice. When nanomaterials, characterized by distinctive physicochemical properties, are integrated with oncolytic bacteria, they achieve mutually complementary advantages and construct efficient and safe nanobiohybrids. In this review, we initially analyze the merits and drawbacks of conventional tumor therapeutic approaches, followed by a detailed examination of the precise oncolysis mechanisms employed by oncolytic bacteria. Subsequently, we focus on harnessing nanomaterial-assisted oncolytic bacteria (NAOB) to augment the effectiveness of tumor therapy and utilizing them as nanotheranostic agents for imaging-guided tumor treatment. Finally, by summarizing and analyzing the current deficiencies of NAOB, this review provides some innovative directions for developing nanobiohybrids, intending to infuse novel research concepts into the realm of solid tumor therapy.

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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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