{"title":"细胞入侵最小化或增长模型中的游动波","authors":"Carles Falcó, Rebecca M. Crossley, Ruth E. Baker","doi":"arxiv-2404.11251","DOIUrl":null,"url":null,"abstract":"We consider a minimal go-or-grow model of cell invasion, whereby cells can\neither proliferate, following logistic growth, or move, via linear diffusion,\nand phenotypic switching between these two states is density-dependent. Formal\nanalysis in the fast switching regime shows that the total cell density in the\ntwo-population go-or-grow model can be described in terms of a single\nreaction-diffusion equation with density-dependent diffusion and proliferation.\nUsing the connection to single-population models, we study travelling wave\nsolutions, showing that the wave speed in the go-or-grow model is always\nbounded by the wave speed corresponding to the well-known Fisher-KPP equation.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":"100 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Travelling waves in a minimal go-or-grow model of cell invasion\",\"authors\":\"Carles Falcó, Rebecca M. Crossley, Ruth E. Baker\",\"doi\":\"arxiv-2404.11251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We consider a minimal go-or-grow model of cell invasion, whereby cells can\\neither proliferate, following logistic growth, or move, via linear diffusion,\\nand phenotypic switching between these two states is density-dependent. Formal\\nanalysis in the fast switching regime shows that the total cell density in the\\ntwo-population go-or-grow model can be described in terms of a single\\nreaction-diffusion equation with density-dependent diffusion and proliferation.\\nUsing the connection to single-population models, we study travelling wave\\nsolutions, showing that the wave speed in the go-or-grow model is always\\nbounded by the wave speed corresponding to the well-known Fisher-KPP equation.\",\"PeriodicalId\":501321,\"journal\":{\"name\":\"arXiv - QuanBio - Cell Behavior\",\"volume\":\"100 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv - QuanBio - Cell Behavior\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/arxiv-2404.11251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Cell Behavior","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2404.11251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Travelling waves in a minimal go-or-grow model of cell invasion
We consider a minimal go-or-grow model of cell invasion, whereby cells can
either proliferate, following logistic growth, or move, via linear diffusion,
and phenotypic switching between these two states is density-dependent. Formal
analysis in the fast switching regime shows that the total cell density in the
two-population go-or-grow model can be described in terms of a single
reaction-diffusion equation with density-dependent diffusion and proliferation.
Using the connection to single-population models, we study travelling wave
solutions, showing that the wave speed in the go-or-grow model is always
bounded by the wave speed corresponding to the well-known Fisher-KPP equation.