细胞入侵最小化或增长模型中的游动波

Carles Falcó, Rebecca M. Crossley, Ruth E. Baker
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引用次数: 0

摘要

我们考虑了细胞侵袭的最小 "去或长 "模型,在该模型中,细胞要么根据对数生长进行甘蔗增殖,要么通过线性扩散进行移动,而这两种状态之间的表型切换取决于密度。在快速切换机制下的形式分析表明,双种群 "去或生长 "模型中的细胞总密度可以用一个单反应扩散方程来描述,该方程的扩散和增殖都与密度有关。利用与单种群模型的联系,我们研究了行波解,结果表明 "去或生长 "模型中的波速总是与著名的费希尔-KPP方程对应的波速相一致。
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Travelling waves in a minimal go-or-grow model of cell invasion
We consider a minimal go-or-grow model of cell invasion, whereby cells can either proliferate, following logistic growth, or move, via linear diffusion, and phenotypic switching between these two states is density-dependent. Formal analysis in the fast switching regime shows that the total cell density in the two-population go-or-grow model can be described in terms of a single reaction-diffusion equation with density-dependent diffusion and proliferation. Using the connection to single-population models, we study travelling wave solutions, showing that the wave speed in the go-or-grow model is always bounded by the wave speed corresponding to the well-known Fisher-KPP equation.
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