M.G. Manzione , R. Kumar , S. Harilal , P. Mishra , K.A. Youb , P.V.T. Fokou , R. Pezzani
{"title":"蔷薇与癌症:哪些证据?","authors":"M.G. Manzione , R. Kumar , S. Harilal , P. Mishra , K.A. Youb , P.V.T. Fokou , R. Pezzani","doi":"10.1016/j.hermed.2024.100875","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p><em>Rosa canina</em> L. is a plant of the Rosaceae family commonly known for being the ancestor of cultivated roses. It is frequently found as a wild plant in almost all the temperate areas of the Northern hemisphere, and it is used in numerous traditional medicines. <em>R canina</em> is used for respiratory problems, gastrointestinal diseases, kidney stones, hypertension and diabetes, osteoarthritis, and muscle and osteoarticular pain.</p></div><div><h3>Methods</h3><p>A literature search was performed using specific search terms, such as rose, <em>Rosa canina</em>, rose hip, rosehip, dog rose, wild rose, ethnopharmacology, traditional use, antioxidant, anti-inflammatory, cancer, anticancer, cytotoxicity, antiproliferative, and apoptosis. Studies on ethnotraditional and pharmacological values were retrieved as well as on isolated compounds or specific extracts on <em>R canina</em>.</p></div><div><h3>Results</h3><p>The use of <em>R canina</em> is based on the phytochemical profile, rich in phenolic compounds and ascorbic acid, which guarantee remarkable anti-inflammatory and antioxidant properties. Tables on phytochemical composition, phenolics and steroids, volatile compounds, and representative studies on the pharmacological activities related to cancer of <em>R canina</em> were reported.</p></div><div><h3>Conclusions</h3><p>This review analyses the phytotherapeutic properties of <em>R canina</em> with a specific emphasis on the anticancer effect in preclinical models, while exploring the mechanisms of action of its phytochemical compounds. In addition, this work paves the way for the exploration of the potential benefits of this plant in human oncology.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100875"},"PeriodicalIF":2.2000,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rosa canina and Cancer: Which Evidence?\",\"authors\":\"M.G. Manzione , R. Kumar , S. Harilal , P. Mishra , K.A. Youb , P.V.T. Fokou , R. Pezzani\",\"doi\":\"10.1016/j.hermed.2024.100875\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p><em>Rosa canina</em> L. is a plant of the Rosaceae family commonly known for being the ancestor of cultivated roses. It is frequently found as a wild plant in almost all the temperate areas of the Northern hemisphere, and it is used in numerous traditional medicines. <em>R canina</em> is used for respiratory problems, gastrointestinal diseases, kidney stones, hypertension and diabetes, osteoarthritis, and muscle and osteoarticular pain.</p></div><div><h3>Methods</h3><p>A literature search was performed using specific search terms, such as rose, <em>Rosa canina</em>, rose hip, rosehip, dog rose, wild rose, ethnopharmacology, traditional use, antioxidant, anti-inflammatory, cancer, anticancer, cytotoxicity, antiproliferative, and apoptosis. Studies on ethnotraditional and pharmacological values were retrieved as well as on isolated compounds or specific extracts on <em>R canina</em>.</p></div><div><h3>Results</h3><p>The use of <em>R canina</em> is based on the phytochemical profile, rich in phenolic compounds and ascorbic acid, which guarantee remarkable anti-inflammatory and antioxidant properties. Tables on phytochemical composition, phenolics and steroids, volatile compounds, and representative studies on the pharmacological activities related to cancer of <em>R canina</em> were reported.</p></div><div><h3>Conclusions</h3><p>This review analyses the phytotherapeutic properties of <em>R canina</em> with a specific emphasis on the anticancer effect in preclinical models, while exploring the mechanisms of action of its phytochemical compounds. In addition, this work paves the way for the exploration of the potential benefits of this plant in human oncology.</p></div>\",\"PeriodicalId\":56077,\"journal\":{\"name\":\"Journal of Herbal Medicine\",\"volume\":\"45 \",\"pages\":\"Article 100875\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Herbal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210803324000320\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324000320","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
导言玫瑰(Rosa canina L.)是一种蔷薇科植物,因其是栽培玫瑰的祖先而闻名。在北半球几乎所有的温带地区,它都是常见的野生植物,并被用于多种传统医药中。方法使用特定的检索词进行文献检索,如玫瑰、蔷薇、玫瑰果、玫瑰臀、狗蔷薇、野蔷薇、民族药理学、传统用途、抗氧化剂、抗炎、癌症、抗癌、细胞毒性、抗增殖和细胞凋亡。结果 犬齿金雀花的使用基于其植物化学成分,富含酚类化合物和抗坏血酸,具有显著的抗炎和抗氧化特性。本综述分析了 R canina 的植物治疗特性,特别强调了其在临床前模型中的抗癌效果,同时探讨了其植物化学成分的作用机制。此外,这项工作还为探索这种植物在人类肿瘤学中的潜在益处铺平了道路。
Rosa canina L. is a plant of the Rosaceae family commonly known for being the ancestor of cultivated roses. It is frequently found as a wild plant in almost all the temperate areas of the Northern hemisphere, and it is used in numerous traditional medicines. R canina is used for respiratory problems, gastrointestinal diseases, kidney stones, hypertension and diabetes, osteoarthritis, and muscle and osteoarticular pain.
Methods
A literature search was performed using specific search terms, such as rose, Rosa canina, rose hip, rosehip, dog rose, wild rose, ethnopharmacology, traditional use, antioxidant, anti-inflammatory, cancer, anticancer, cytotoxicity, antiproliferative, and apoptosis. Studies on ethnotraditional and pharmacological values were retrieved as well as on isolated compounds or specific extracts on R canina.
Results
The use of R canina is based on the phytochemical profile, rich in phenolic compounds and ascorbic acid, which guarantee remarkable anti-inflammatory and antioxidant properties. Tables on phytochemical composition, phenolics and steroids, volatile compounds, and representative studies on the pharmacological activities related to cancer of R canina were reported.
Conclusions
This review analyses the phytotherapeutic properties of R canina with a specific emphasis on the anticancer effect in preclinical models, while exploring the mechanisms of action of its phytochemical compounds. In addition, this work paves the way for the exploration of the potential benefits of this plant in human oncology.
期刊介绍:
The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.