杜氏肌肉萎缩症患者使用可穿戴设备获得的体力活动/心率变异性数据与定时运动功能测试之间的关联:一项试点研究

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-04-06 DOI:10.3233/jnd-230142
A. Nakamura, Tsuyoshi Matsumura, Yasuhiro Takeshima, Satoshi Kuru, Manami Imazaki, Hidenori Nonomura, Hisanobu Kaiya
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引用次数: 0

摘要

背景杜氏肌营养不良症(DMD)是一种毁灭性的X连锁肌肉疾病。本研究中,我们使用可穿戴设备检查了 DMD 患者和健康受试者在体力活动和心率变异性(HRV)方面的差异,并研究了这些参数与 DMD 患者运动功能之间的关系。方法受试者为 7 名 DMD 患者和 8 名健康男性,他们的体力活动和心率变异性由可穿戴设备提供。这些数据用于研究 DMD 患者的体力活动和心率变异参数与定时运动功能测试(从仰卧到站立的时间、10 米步行时间 (10MWT)、北极星活动评估 (NSAA) 和 6 分钟步行测试 (6MWT))之间的关系。结果DMD 患者的 24 小时体力活动、脂肪燃烧、总步数和活动距离、平均步频、步行时的平均运动强度、运动量、步行时的前倾程度、最大心率、归一化低频功率(LF norm)和最大运动强度均低于对照组受试者。体力活动和心率变异参数与从仰卧到站立的时间无关。10MWT 与平均心率呈正相关,而 NSAA 与唤醒时的平均心率、总频功率(TF)和极低频功率(VLF)呈负相关。结论:与正常儿童不同且与运动功能评估相关的体力活动和心率变异指数可作为数字生物标记。
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The Association Between Physical Activity/Heart Rate Variability Data Obtained Using a Wearable Device and Timed Motor Functional Tests in Patients with Duchenne Muscular Dystrophy: A Pilot Study.
Background Duchenne muscular dystrophy (DMD) is a devastating X-linked muscle disease. Clinical evaluation of DMD uses patient-intensive motor function tests, and the recent development of wearable devices allows the collection of a variety of biometric information, including physical activity. Objective In this study, we examined differences in physical activity and heart rate variability (HRV) between patients with DMD and healthy subjects using a wearable device, and investigated any association between these parameters and motor function in patients with DMD. Methods Participants were 7 patients with DMD and 8 healthy males, whose physical activity and HRV were provided by a wearable device. These data were used to investigate the relationship between both physical activity and HRV parameters and timed motor functional tests [Time to stand from supine, 10-meter walking time (10MWT), North Star Ambulatory Assessment (NSAA), and 6-minute walking test (6MWT)] in patients with DMD. Results Results of 24-hours physical activity, fat burning, total number of steps and active distance, average step rate, average exercise intensity during walking, exercise, degree of forward lean during walking, maximum heart rate, normalized low frequency power (LF norm), and maximum exercise intensity in patients with DMD were lower than those in control subjects. Physical activity and HRV parameters did not correlate with the time to stand from supine. The 10MWT positively correlated with average heart rate, while NSAA negatively correlated with average heart rate, total frequency power (TF), and very low frequency power (VLF) during arousal. The 6MWT negatively correlated with ratio LF/high frequency power (HF). CONCLUSIONS Physical activity and HRV indices that differ from those of normal children and that correlate with motor function assessment may serve as digital biomarkers.
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