Selective oxidation by TS-1 coupled with in-situ synthesised H2O2

Feedstock valorisation with preformed H₂O₂ in conjunction with titanosilicate zeotypes is particularly attractive due to the increased selectivity, lower operating temperatures and improved process efficiency (particularly lower energy usage and enhanced atom economy) compared to aerobic pathways or alternative stoichiometric oxidants. However, numerous environmental and financial concerns associated with the application of commercial H₂O₂ remain. These concerns have led to a growing interest in the application of the in-situ synthesized oxidant for a range of chemical transformations. Herein, we provide an overview of the key contributions to this emerging field of oxidative catalysis, with a particular focus on propene epoxidation and ketone ammoximation, which are currently two crucial industrial-scale processes that utilise preformed H₂O₂ with the titanosilicate catalyst TS-1 for chemical synthesis. This contribution will highlight the potential for in-situ H₂O₂-mediated feedstock upgrading to replace existing technologies and contribute to the declared sustainability goals of the chemical synthesis sector.