2 型糖尿病患者大脑形态计量网络的变化及其与记忆功能障碍的关系

IF 1.8 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental Neurobiology Pub Date : 2024-04-30 DOI:10.5607/en24005
Rye Young Kim, Yoonji Joo, Eunji Ha, Haejin Hong, Chaewon Suh, Youngeun Shim, Hyeonji Lee, Yejin Kim, Jae-Hyoung Cho, Sujung Yoon, In Kyoon Lyoo
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引用次数: 0

摘要

认知功能障碍是 2 型糖尿病(T2DM)的一个重要并发症,甚至在疾病的早期阶段就可能表现出来。尽管有证据表明早期的T2DM患者会出现整体脑萎缩和相关的认知功能障碍,但目前尚未发现易受这些变化影响的特定区域。该研究招募了病程不到五年且无慢性并发症的 T2DM 患者(T2DM 组,100 人)和人口统计学相似的健康对照组(对照组,50 人)。对高分辨率 T1 加权磁共振成像数据进行了独立成分分析,以确定指示形态网络的重要结构成分。在这些网络中,比较了各组的灰质体积,并评估了记忆表现的差异。在 T2DM 组中,研究了这些网络中灰质体积的变化与记忆能力下降之间的关系。在已确定的形态计量网络中,T2DM 组与对照组相比,楔前叶(经 Bonferroni 校正后 p=0.003)和岛叶-小脑(经 Bonferroni 校正后 p=0.024)网络的灰质体积均有所减少。T2DM患者的记忆力明显低于对照组(P=0.001)。在 T2DM 组中,楔前叶(r=0.316,p=0.001)和岛叶-小脑(r=0.199,p=0.047)网络灰质体积的减少与记忆能力的下降相关。我们的研究结果表明,楔前叶和岛叶-小丘网络结构的改变以及记忆功能障碍可在确诊T2DM后的头5年内表现出来。
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Alterations in Brain Morphometric Networks and Their Relationship with Memory Dysfunction in Patients with Type 2 Diabetes Mellitus.

Cognitive dysfunction, a significant complication of type 2 diabetes mellitus (T2DM), can potentially manifest even from the early stages of the disease. Despite evidence of global brain atrophy and related cognitive dysfunction in early-stage T2DM patients, specific regions vulnerable to these changes have not yet been identified. The study enrolled patients with T2DM of less than five years' duration and without chronic complications (T2DM group, n=100) and demographically similar healthy controls (control group, n=50). High-resolution T1-weighted magnetic resonance imaging data were subjected to independent component analysis to identify structurally significant components indicative of morphometric networks. Within these networks, the groups' gray matter volumes were compared, and distinctions in memory performance were assessed. In the T2DM group, the relationship between changes in gray matter volume within these networks and declines in memory performance was examined. Among the identified morphometric networks, the T2DM group exhibited reduced gray matter volumes in both the precuneus (Bonferroni-corrected p=0.003) and insular-opercular (Bonferroni-corrected p=0.024) networks relative to the control group. Patients with T2DM demonstrated significantly lower memory performance than the control group (p=0.001). In the T2DM group, reductions in gray matter volume in both the precuneus (r=0.316, p=0.001) and insular-opercular (r=0.199, p=0.047) networks were correlated with diminished memory performance. Our findings indicate that structural alterations in the precuneus and insular-opercular networks, along with memory dysfunction, can manifest within the first 5 years following a diagnosis of T2DM.

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来源期刊
Experimental Neurobiology
Experimental Neurobiology Neuroscience-Cellular and Molecular Neuroscience
CiteScore
4.30
自引率
4.20%
发文量
29
期刊介绍: Experimental Neurobiology is an international forum for interdisciplinary investigations of the nervous system. The journal aims to publish papers that present novel observations in all fields of neuroscience, encompassing cellular & molecular neuroscience, development/differentiation/plasticity, neurobiology of disease, systems/cognitive/behavioral neuroscience, drug development & industrial application, brain-machine interface, methodologies/tools, and clinical neuroscience. It should be of interest to a broad scientific audience working on the biochemical, molecular biological, cell biological, pharmacological, physiological, psychophysical, clinical, anatomical, cognitive, and biotechnological aspects of neuroscience. The journal publishes both original research articles and review articles. Experimental Neurobiology is an open access, peer-reviewed online journal. The journal is published jointly by The Korean Society for Brain and Neural Sciences & The Korean Society for Neurodegenerative Disease.
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