维生素 D 在免疫调节和形成共生微生物群落中发挥作用。Reis e Sousa及其同事发现，缺乏Gc球蛋白（Gc-/-小鼠）的小鼠对肿瘤的抵抗力增强。耐人寻味的是，同舍的野生型小鼠以及接受Gc-/-小鼠粪便转移的小鼠也表现出更强的肿瘤免疫力。作者发现，维生素 D 改变了肠上皮细胞的基因表达，从而促进了脆弱拟杆菌的繁殖，而牺牲了普雷沃特氏菌（两者都是正常肠道微生物群的一部分）。在野生型小鼠体内补充维生素 D 或口服脆弱拟杆菌可增强肿瘤免疫力。在人类身上也发现了维生素 D 与肿瘤免疫力之间的联系，丹麦一个包含 150 万人的数据库分析表明，维生素 D 水平低与癌症发病率增加有关。在癌症患者中，表明维生素 D 受体激活的基因特征与存活率提高和对免疫疗法的反应改善有关。总之，这些结果从一个新的角度揭示了维生素 D、癌症和微生物组之间的关系，并强调维生素 D 是抗肿瘤免疫的潜在决定因素。
期刊介绍：
Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
