Juan Camilo Grisales-Nieto, Sérgio Luiz Bessa Luz, Valdinete Alves do Nascimento, Felipe Gomes Naveca, Luz Mila Murcia-Montaño, Kelly Natalia Romero-Vesga, Olga Eshter Bellido-Cuellar, José Joaquín Carvajal-Cortés
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引用次数: 0
摘要
目的：我们报告了在哥伦比亚边境地区发现的首例奥罗普切热病例：我们报告了在哥伦比亚边境地区发现的首例奥罗普切热病例：利用多重实时聚合酶链反应（PCR）、基因测序和 2019 年登革热疫情期间的临床特征，对向登革热等流行病学监测系统通报的病例中的 175 份样本进行了分析：根据 M 和 S 基因组片段最大似然法（ML）分析，莱蒂西亚的奥罗普切病毒（OROV）分离株属于第 2 系，与厄瓜多尔埃斯梅拉达斯和哥伦比亚图尔瓦科的样本具有共同祖先。患者：一名居住在莱蒂西亚市边境居民区的妇女，有以下症状：发烧、头痛、眶后疼痛和肌痛：主要结论：这种跨境监测有助于提醒人们注意该地区虫媒病毒的出入境情况，而公共卫生监测系统对这些情况往往报告不足。
First case of Oropouche fever detected in the international border region of the Colombian Amazon: clinical characteristics and molecular diagnosis.
Objectives: We report the first case of Oropouche fever detected in the border region of Colombia.
Methods: Using a multiplex real-time polymerase chain reaction (PCR), genetic sequencing and clinical characteristics during the dengue epidemic in 2019, a total of 175 samples were analysed, from cases notified to the system epidemiological surveillance such as dengue.
Findings: The Oropouche virus (OROV) isolate from Leticia belongs to lineage 2 according to both M and S genome segments maximum likelihood (ML) analysis, shares a common ancestor with samples obtained in Esmeraldas, Ecuador and Turbaco, Colombia. The patient: a woman resident in the border neighbourhood of the municipality of Leticia had the following symptoms: fever, headache, retro-orbital pain and myalgias.
Main conclusion: This cross-border surveillance can be useful to give an alert about the entry or exit of arboviruses circulation in the region, which are often underreported in public health surveillance systems.
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