Lien Anh Ha Do, Naranzul Tsedenbal, Chimidregzen Khishigmunkh, Bazarkhuu Tserendulam, Lkhagvadorj Altanbumba, Dashtseren Luvsantseren, Munkhchuluun Ulziibayar, Bujinlkham Suuri, Dorj Narangerel, Bilegtsaikhan Tsolmon, Sodbayar Demberelsuren, Casey L Pell, Sam Manna, Catherine Satzke, Cattram Nguyen, Tuya Mungun, Claire von Mollendorf, Darmaa Badarch, Kim Mulholland
{"title":"2015-2021 年蒙古乌兰巴托儿童呼吸道合胞病毒和流感感染情况","authors":"Lien Anh Ha Do, Naranzul Tsedenbal, Chimidregzen Khishigmunkh, Bazarkhuu Tserendulam, Lkhagvadorj Altanbumba, Dashtseren Luvsantseren, Munkhchuluun Ulziibayar, Bujinlkham Suuri, Dorj Narangerel, Bilegtsaikhan Tsolmon, Sodbayar Demberelsuren, Casey L Pell, Sam Manna, Catherine Satzke, Cattram Nguyen, Tuya Mungun, Claire von Mollendorf, Darmaa Badarch, Kim Mulholland","doi":"10.1111/irv.13303","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Data available for RSV and influenza infections among children < 2 years in Mongolia are limited. We present data from four districts of Ulaanbaatar from April 2015 to June 2021.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study was nested in an enhanced surveillance project evaluating pneumococcal conjugate vaccine (PCV13) impact on the incidence of hospitalized lower respiratory tract infections (LRTIs). Our study was restricted to children aged < 2 years with arterial O<sub>2</sub> saturation < 93% and children with radiological pneumonia. Nasopharyngeal (NP) swabs collected at admission were tested for RSV and influenza using qRT-PCR. NP swabs of all patients with radiological pneumonia and of a subset of randomly selected NP swabs were tested for <i>S. pneumoniae</i> (<i>S.p</i>.) by qPCR and for serotypes by culture and DNA microarray.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among 5705 patients, 2113 (37.0%) and 386 (6.8%) had RSV and influenza infections, respectively. Children aged 2–6 months had a higher percentage of very severe RSV infection compared to those older than 6 months (42.2% versus 31.4%, <i>p</i>-value Fisher's exact = 0.001). <i>S.p</i>. carriage was detected in 1073/2281 (47.0%) patients. Among <i>S.p</i>. carriage cases, 363/1073 (33.8%) had <i>S.p</i>. and RSV codetection, and 82/1073 (7.6%) had <i>S.p</i>. and influenza codetection. <i>S.p</i>. codetection with RSV/influenza was not associated with more severe LRTIs, compared to only RSV/influenza cases.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and <i>S.p</i>. was not associated with increased severity.</p>\n </section>\n </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"18 5","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13303","citationCount":"0","resultStr":"{\"title\":\"Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015–2021\",\"authors\":\"Lien Anh Ha Do, Naranzul Tsedenbal, Chimidregzen Khishigmunkh, Bazarkhuu Tserendulam, Lkhagvadorj Altanbumba, Dashtseren Luvsantseren, Munkhchuluun Ulziibayar, Bujinlkham Suuri, Dorj Narangerel, Bilegtsaikhan Tsolmon, Sodbayar Demberelsuren, Casey L Pell, Sam Manna, Catherine Satzke, Cattram Nguyen, Tuya Mungun, Claire von Mollendorf, Darmaa Badarch, Kim Mulholland\",\"doi\":\"10.1111/irv.13303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Data available for RSV and influenza infections among children < 2 years in Mongolia are limited. We present data from four districts of Ulaanbaatar from April 2015 to June 2021.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This study was nested in an enhanced surveillance project evaluating pneumococcal conjugate vaccine (PCV13) impact on the incidence of hospitalized lower respiratory tract infections (LRTIs). Our study was restricted to children aged < 2 years with arterial O<sub>2</sub> saturation < 93% and children with radiological pneumonia. Nasopharyngeal (NP) swabs collected at admission were tested for RSV and influenza using qRT-PCR. NP swabs of all patients with radiological pneumonia and of a subset of randomly selected NP swabs were tested for <i>S. pneumoniae</i> (<i>S.p</i>.) by qPCR and for serotypes by culture and DNA microarray.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Among 5705 patients, 2113 (37.0%) and 386 (6.8%) had RSV and influenza infections, respectively. Children aged 2–6 months had a higher percentage of very severe RSV infection compared to those older than 6 months (42.2% versus 31.4%, <i>p</i>-value Fisher's exact = 0.001). <i>S.p</i>. carriage was detected in 1073/2281 (47.0%) patients. Among <i>S.p</i>. carriage cases, 363/1073 (33.8%) had <i>S.p</i>. and RSV codetection, and 82/1073 (7.6%) had <i>S.p</i>. and influenza codetection. <i>S.p</i>. codetection with RSV/influenza was not associated with more severe LRTIs, compared to only RSV/influenza cases.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. 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Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015–2021
Background
Data available for RSV and influenza infections among children < 2 years in Mongolia are limited. We present data from four districts of Ulaanbaatar from April 2015 to June 2021.
Methods
This study was nested in an enhanced surveillance project evaluating pneumococcal conjugate vaccine (PCV13) impact on the incidence of hospitalized lower respiratory tract infections (LRTIs). Our study was restricted to children aged < 2 years with arterial O2 saturation < 93% and children with radiological pneumonia. Nasopharyngeal (NP) swabs collected at admission were tested for RSV and influenza using qRT-PCR. NP swabs of all patients with radiological pneumonia and of a subset of randomly selected NP swabs were tested for S. pneumoniae (S.p.) by qPCR and for serotypes by culture and DNA microarray.
Results
Among 5705 patients, 2113 (37.0%) and 386 (6.8%) had RSV and influenza infections, respectively. Children aged 2–6 months had a higher percentage of very severe RSV infection compared to those older than 6 months (42.2% versus 31.4%, p-value Fisher's exact = 0.001). S.p. carriage was detected in 1073/2281 (47.0%) patients. Among S.p. carriage cases, 363/1073 (33.8%) had S.p. and RSV codetection, and 82/1073 (7.6%) had S.p. and influenza codetection. S.p. codetection with RSV/influenza was not associated with more severe LRTIs, compared to only RSV/influenza cases.
Conclusion
In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and S.p. was not associated with increased severity.
期刊介绍：
Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases.
Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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