对大鼠尾部受压时的机械行为进行量化。

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2024-01-01 DOI:10.3233/BME-230170
Kevin D Moore, John Z Wu, Kristine Krajnak, Christopher Warren, Renguang G Dong
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引用次数: 0

摘要

背景:振动引起的手指病变可能与手指对振动暴露的静态和动态综合反应有关。为了研究手指失调的机理,我们建立了一个新的大鼠尾部模型来模拟手指振动和压力暴露。然而,要改进该模型及其应用,还需要更好地了解尾部在压缩过程中的机械行为:研究大鼠尾部在压缩过程中的静态和随时间变化的力响应:方法:使用微机械系统在三种变形速度和三种变形幅度下对 Sprague-Dawley 尸体大鼠尾部进行压缩试验。测量了接触宽度以及力和变形的时间历程。此外,还进行了力松弛试验,并使用 Prony 系列来模拟尾部的力松弛行为:结果:大鼠尾部的力-变形和刚度-变形关系具有很强的非线性和时间依赖性。力/刚度随着变形和变形速度的增加而增加。大鼠尾部随时间变化的力-松弛特性可以用普罗尼数列很好地描述:我们成功地量化了大鼠尾部在压缩下的静态和随时间变化的力响应。确定的鼠尾力学行为有助于改进鼠尾模型及其应用。
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Quantification of mechanical behavior of rat tail under compression.

Backgorund: The development of vibration-induced finger disorders is likely associated with combined static and dynamic responses of the fingers to vibration exposure. To study the mechanism of the disorders, a new rat-tail model has been established to mimic the finger vibration and pressure exposures. However, the mechanical behavior of the tail during compression needs to be better understood to improve the model and its applications.

Objective: To investigate the static and time-dependent force responses of the rat tail during compression.

Methods: Compression tests were conducted on Sprague-Dawley cadaver rat tails using a micromechanical system at three deformation velocities and three deformation magnitudes. Contact-width and the time-histories of force and deformation were measured. Additionally, force-relaxation tests were conducted and a Prony series was used to model the force-relaxation behavior of the tail.

Results: The rat tails' force-deformation and stiffness-deformation relationships were strongly nonlinear and time-dependent. Force/stiffness increased with an increase in deformation and deformation velocity. The time-dependent force-relaxation characteristics of the tails can be well described using a Prony series.

Conculsions: We successfully quantified the static and time-dependent force responses of rat tails under compression. The identified mechanical behavior of the tail can help improve the rat-tail model and its applications.

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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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