使用 2,2′-联苯酚/B(OH)3 系统的有机催化费舍尔吲哚化反应

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-05-17 DOI:10.1055/s-0043-1775363

Kenji Sugimoto, Yuji Matsuya, Yusei Wada, Fumino Kitamura

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引用次数: 0

摘要

通过将 2,2′-联苯酚 (10 mol%) 和 B(OH)3 (30 mol%) 作为弱酸、易得酸和易于处理的酸结合在一起，建立了一种有机催化的费歇尔吲哚化反应。MgSO4 能有效清除 NH3（一种可能的酸催化剂毒物），加入 MgSO4 似乎是这一工艺成功的关键。使用这种方法可以获得相应的吲哚，产率高达 91%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Organocatalytic Fischer Indolization Using the 2,2′-Biphenol/ B(OH)3 System

An organocatalyzed Fischer indolization is established by combining 2,2′-biphenol (10 mol%) and B(OH)3 (30 mol%) as weak, readily available, and easy-to-handle acids. The inclusion of MgSO4, which efficiently scavenges NH3 (a possible acid catalyst poison), appears to be key to the success of this process. The corresponding indoles are obtained in yields of up to 91% using this method.y

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.