立体定向手术及其在阿尔茨海默病大鼠模型中的应用

Esra Tekin
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引用次数: 0

摘要

立体定向手术是一种可用于定位体内小目标并对特定目标进行干预和/或治疗(如注射)的技术。除临床实践外,立体定向手术还经常用于在实验研究中创建神经疾病模型。在确定特定脑区后,使用啮齿类动物大脑坐标图谱,用适当的玻璃注射器进行注射。阿尔茨海默病(AD)是最常见的痴呆症病因,目前尚无治疗方法。通过立体定向手术和注射不同物质,可以在啮齿类动物体内创建阿尔茨海默病模型。这些阿狄森氏病模型代表了这种疾病,尤其常用于药物开发研究。根据创建方式,AD 类模型似乎可以研究不同的单向发育机制。然而,AD 是一种多向疾病。使用不同方法创建的 AD 啮齿动物模型具有特定的属性。本综述旨在解释立体定向手术的基本方面,并讨论用这种手术技术和其他方法创建的AD啮齿动物模型。
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Stereotactic surgery and its application in Alzheimer’s disease rat models
Stereotactic surgery is a technique that can be used to locate small targets in the body and administer interventions and/or treatments, such as injections, to the specific target. Stereotactic surgery is frequently used to create neurological disease models in experimental research in addition to clinical practice. The injection is administered with appropriate glass injectors using the rodent brain coordinate atlas after the specific brain region is determined. Alzheimer’s disease (AD), the most common cause of dementia, has no curative treatment yet. AD models can be created in rodents through stereotactic surgery and injections of different substances. These AD models represent the disease and are frequently used especially for drug development studies. AD-like models seem to examine different and unidirectional developmental mechanisms according to the creating way. However, AD is a multidirectional disease. AD rodent models created using different methods have specific properties. This review aims to explain the basic aspects of stereotactic surgery and to discuss AD rodent models created with this surgical technique and also with alternate methods.
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