用于治疗哮喘的硫酸特布他林药用口香糖的配方和评估

Shweta Mishra, Sunil Kumar Shah, Dubey Bk
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引用次数: 0

摘要

目的:本实验旨在通过将硫酸特布他林配制成药用口香糖,提高其生物利用度:本实验旨在通过将硫酸特布他林配制成药用口香糖来提高其生物利用度:方法:采用玉米蛋白作为口香糖的基质,并采用熔化工艺,制作出具有预期效果的口香糖:结果:所有配方的厚度横向在 3.61 至 3.68 毫米之间,纵向在 5.22 至 5.41 毫米之间。所有配方的硬度值在 3.1 至 3.4 公斤/平方厘米之间。所有配方的重量变化在 1.6% 到 2.1% 之间。所有配方的药量相同,在 95.2% 和 96.9% 之间。通过检测半小时后的样品,研究了硫酸特布他林口香糖(TCGs)在模拟唾液(pH 值为 6.8 的缓冲溶液)中的药物释放情况。结果发现,在 30 分钟内,配方中的药物释放量从 64.28% 到 89.56%不等:结论:当配方中的胶基(玉米蛋白)含量增加时,药物的释放量减少。研究发现,30 分钟后,TCG1 释放的硫酸特布他林比例最高。因此,TCG1 可被视为目前最优质的制剂。
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FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF TERBUTALINE SULFATE FOR THE ASTHAMATIC MANAGEMENT
Objective: This experiment aimed to improve the bioavailability of terbutaline sulfate by formulating it as medicated chewing gum. Methods: By employing zein as the gum foundation and the melting process, chewing gum was created with the desired outcome. Results: All formulations had thicknesses ranging from 3.61 to 3.68 mm in the lateral direction and from 5.22 to 5.41 mm in the longitudinal direction. All formulations had hardness values between 3.1 and 3.4 kg/cm2. All formulations had weight variations between 1.6% and 2.1%. All of the formulations had the same quantity of medication, which varied between 95.2 and 96.9%. Drug release from terbutaline sulfate chewing gum (TCGs) in simulated saliva (pH 6.8 buffer solution) was investigated by examining the samples up to a half-hour later. It was discovered that the drug release from the formulations ranged from 64.28 to 89.56% in 30 min. Conclusion: The release of the medication was reduced when the gum basis (zein) content in the formulations was increased. It was discovered that, after 30 min, TCG1 emitted the most proportion of terbutaline sulfate. As a result, it may be regarded as the finest formulation available.
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