老年患者口腔液中的神经营养素和血管内皮生长因子:对慢性牙周炎和口腔扁平苔藓的诊断价值

V. Bazarnyi, M. Kopenkin, L. Polushina, E. A. Sementsova, Y. Mandra
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摘要

目的评估成熟的老年慢性牙周炎和口腔扁平苔藓患者口腔液中的血管内皮生长因子 A 和脑源性神经营养因子。材料和方法。研究涉及 56 名参与者。对照组由 18-44 岁的健康志愿者组成(10 人)。对比组包括 60-74 岁相对健康的老年人(12 人)。与年龄相关的牙科疾病患者分组包括:45-59 岁的中度慢性牙周炎成熟期患者(10 人)和老年患者(14 人),以及患有口腔扁平苔藓的老年患者(10 人)。患者均接受了牙科检查。唾液中神经营养素和血管内皮生长因子 A 的含量(BDNF/ NGF beta/ VEGF-A 人类 ProcartaPlex Simplex 试剂盒,Invitrogen 公司,美国)是通过磁性微球多参数荧光分析法(xMAP,Luminex 200,美国)按照生产商的协议测定的。结果显示各组脑源性神经营养因子和神经生长因子 beta 的水平无差异。口腔扁平苔藓老年患者获得的血管生成因子最高,其诊断价值由 ROC 分析评估。该测试的准确度为中等(AUC=0.875)。结论血管内皮生长因子A可用于老年口腔扁平苔藓患者的实验室监测。
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Neurotrophins and vascular endothelial growth factor in oral fluid of elderly patients: diagnostic value for chronic periodontitis and oral lichen planus
Objective. To evaluate the vascular endothelial growth factor A and brain-derived neurotrophic factor in the oral fluid of mature and elderly patients with chronic periodontitis and oral lichen planus. Materials and methods. The study involved 56 participants. The control group consisted of healthy volunteers aged 18–44 (n=10). The comparison group included relatively healthy elderly people aged 60–74 (n=12). The distinguished groups of patients with age-associated dental diseases included: moderate chronic periodontitis mature patients of 45–59 years (n=10) and elderly patients (n=14), as well as elderly patients with oral lichen planus (n=10). The patients underwent dental examination. The content of neurotrophins and vascular endothelial growth factor A in saliva (BDNF/ NGF beta/ VEGF-A Human ProcartaPlex Simplex Kit, Invitrogen, USA) was determined by the multiparametric fluorescence analysis with magnetic microspheres (xMAP, Luminex 200, USA) in compliance with the manufacturer protocol. Results. The groups reveal no differences in the level of brain-derived neurotrophic factor and nerve growth factor beta. The elderly patients with oral lichen planus were found to obtain the highest angiogenesis factor, which diagnostic value was assessed by ROC-analysis. The test appears moderately accurate (AUC=0.875). Conclusion. Vascular endothelial growth factor A can be considered for laboratory monitoring of elderly patients with oral lichen planus.
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