Pub Date : 2024-05-19DOI: 10.34215/1609-1175-2024-1-92-99
L. L. Sadovskaya
The study reveals the great importance of open educational resources (OER) in the field of medical education and scientific activity. Objective. To develop an “OER navigator for medical community”, containing metadata of information resources with open free access. These resources are intended for use in curricula at all stages of medical education, in scientific activities and self-education. At the present stage, the social significance of education in terms of the world concept of “sustainable development” is defined as the most important component and means of survival for civilization (UNESCO). In medicine, with its special mission to preserve the health of the population, the urgent task consists in the training of highly qualified personnel. Close connection of the future of mankind with the processes of digitalization determines the availability of information resources and the use of modern technologies as key aspects of the organization of educational processes. The analysis of the scientific literature and the study of the experience of OER application revealed that OER represent an important tool in the information support of the scientific and educational sphere. OER contribute to forming a personal educational environment, learning continuously and improving skills worldwide, in perpetuity and regardless of financial capabilities. The amount of data presented on the Internet is huge, therefore, the search for necessary information takes a significant amount of time. The developed Navigator (http://lib-os.ru/obrazovatelnye-resursy/navigator-oor-medicinskogo-soobshhestva/) provides meta-data of information resources with open free access, thereby allowing representatives of the medical community at all levels of education and research to quickly and effectively find reliable scientific data and peer-reviewed sources of information.
{"title":"Open educational resources for medical community","authors":"L. L. Sadovskaya","doi":"10.34215/1609-1175-2024-1-92-99","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-92-99","url":null,"abstract":"The study reveals the great importance of open educational resources (OER) in the field of medical education and scientific activity. Objective. To develop an “OER navigator for medical community”, containing metadata of information resources with open free access. These resources are intended for use in curricula at all stages of medical education, in scientific activities and self-education. At the present stage, the social significance of education in terms of the world concept of “sustainable development” is defined as the most important component and means of survival for civilization (UNESCO). In medicine, with its special mission to preserve the health of the population, the urgent task consists in the training of highly qualified personnel. Close connection of the future of mankind with the processes of digitalization determines the availability of information resources and the use of modern technologies as key aspects of the organization of educational processes. The analysis of the scientific literature and the study of the experience of OER application revealed that OER represent an important tool in the information support of the scientific and educational sphere. OER contribute to forming a personal educational environment, learning continuously and improving skills worldwide, in perpetuity and regardless of financial capabilities. The amount of data presented on the Internet is huge, therefore, the search for necessary information takes a significant amount of time. The developed Navigator (http://lib-os.ru/obrazovatelnye-resursy/navigator-oor-medicinskogo-soobshhestva/) provides meta-data of information resources with open free access, thereby allowing representatives of the medical community at all levels of education and research to quickly and effectively find reliable scientific data and peer-reviewed sources of information.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"120 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-19DOI: 10.34215/1609-1175-2024-1-75-78
G. A. Torohtij, S. A. Belov
Neurological disorders are widely recognized as the most frequent and dangerous complication of neglected forms of spinal tuberculosis, typically leading to disability. Since tuberculous spondylitis remains free from pathognomonic clinical symptoms, the disease should be suspected in case of ineffective treatment of a non-tuberculous disease with a particular form of spinal tuberculosis to be behind. The diagnostic algorithm, being implemented from the initial stage of tuberculous osteitis formation, involves timely anti-tuberculosis treatment and correct management of patients, thereby making the basis for preventing the neurological disorders and disability of patients. The presented clinical cases indicate the advantage of an integrated approach in the diagnosis of this pathology in terms of establishing the tuberculous etiology of spondylitis.
{"title":"Difficulties in the diagnosis of spinal tuberculosis (clinical observation)","authors":"G. A. Torohtij, S. A. Belov","doi":"10.34215/1609-1175-2024-1-75-78","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-75-78","url":null,"abstract":"Neurological disorders are widely recognized as the most frequent and dangerous complication of neglected forms of spinal tuberculosis, typically leading to disability. Since tuberculous spondylitis remains free from pathognomonic clinical symptoms, the disease should be suspected in case of ineffective treatment of a non-tuberculous disease with a particular form of spinal tuberculosis to be behind. The diagnostic algorithm, being implemented from the initial stage of tuberculous osteitis formation, involves timely anti-tuberculosis treatment and correct management of patients, thereby making the basis for preventing the neurological disorders and disability of patients. The presented clinical cases indicate the advantage of an integrated approach in the diagnosis of this pathology in terms of establishing the tuberculous etiology of spondylitis.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"122 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-19DOI: 10.34215/1609-1175-2024-1-88-91
M. K. Kubanychbekov, D. B. Shayakhmetov, D. A. Adambekov, A. R. Tsoi, I. S. Aldzhambayeva
Purulent-inflammatory diseases of the maxillofacial region (MFR) refer to frequent complications of odontogenic inflammatory processes. The successful treatment of this pathology is based on adequate drainage of the pustule, complete evacuation of wound exudates and effective local therapy of the wound. The paper presents the flow-vacuum-washing isolation device as an effective method of comprehensive treatment for MFR abscesses and phlegmons caused by antibiotic-resistant strains of microorganisms and in patients with poor immunologic resistance.
{"title":"Using flow-vacuum-washing isolation device for comprehensive treatment of maxillofacial purulent-inflammatory wounds","authors":"M. K. Kubanychbekov, D. B. Shayakhmetov, D. A. Adambekov, A. R. Tsoi, I. S. Aldzhambayeva","doi":"10.34215/1609-1175-2024-1-88-91","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-88-91","url":null,"abstract":"Purulent-inflammatory diseases of the maxillofacial region (MFR) refer to frequent complications of odontogenic inflammatory processes. The successful treatment of this pathology is based on adequate drainage of the pustule, complete evacuation of wound exudates and effective local therapy of the wound. The paper presents the flow-vacuum-washing isolation device as an effective method of comprehensive treatment for MFR abscesses and phlegmons caused by antibiotic-resistant strains of microorganisms and in patients with poor immunologic resistance.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"124 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-19DOI: 10.34215/1609-1175-2024-1-82-87
A. Yarikov, A. Vishnevsky, A. S. Filyaeva, E. A. Pavlova, O. Perlmutter, A. Fraerman, V. N. Voloshin
The study presents a clinical case of complex treatment of a patient with high comorbidity (Charlson comorbidity index = 6 points) who had severe sepsis (SOFA score = 8 points) with multiple foci of pyogenic infection (spinal epiduritis, paravertebral and subdural abscesses, purulent meningitis, bilateral lower lobe pneumonia). The syndrome-based approach with the use of minimally invasive approaches in the early stages (no later than 12 hours from the onset of clinical manifestations of the disease) ensured a favorable outcome. Based on the results of surgical treatment, a conclusion was made about the tactics of surgical treatment in patients with spinal infection against the background of sepsis.
{"title":"Case of successful treatment of spinal infection in a patient with high comorbidity and septic manifestations","authors":"A. Yarikov, A. Vishnevsky, A. S. Filyaeva, E. A. Pavlova, O. Perlmutter, A. Fraerman, V. N. Voloshin","doi":"10.34215/1609-1175-2024-1-82-87","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-82-87","url":null,"abstract":"The study presents a clinical case of complex treatment of a patient with high comorbidity (Charlson comorbidity index = 6 points) who had severe sepsis (SOFA score = 8 points) with multiple foci of pyogenic infection (spinal epiduritis, paravertebral and subdural abscesses, purulent meningitis, bilateral lower lobe pneumonia). The syndrome-based approach with the use of minimally invasive approaches in the early stages (no later than 12 hours from the onset of clinical manifestations of the disease) ensured a favorable outcome. Based on the results of surgical treatment, a conclusion was made about the tactics of surgical treatment in patients with spinal infection against the background of sepsis.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"109 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-19DOI: 10.34215/1609-1175-2024-1-79-81
N. A. Surkov, O. M. Dondup, F. S. Piloyan, D. M. Redkina, A. A. Zaripova
Recurrent abdominal pain in childhood and adolescence may be indicative of chronic mesenteric ischemia with median arcuate ligament syndrome as a result of compression of the celiac artery by the median arcuate ligament of the diaphragm and its internal crura, neurofibrous tissue of the celiac plexus. The presence of symptoms characteristic of various diseases of gastrointestinal tract organs, absence of pathognomonic signs and complex approach in diagnostics of abdominal cavity vascular system, insufficient awareness of specialists of children’s outpatient clinics determine the urgency of timely diagnostics and treatment of patients with this pathology. Median arcuate ligament syndrome, or Dunbar syndrome, is more often a congenital malformation. This syndrome can be considered as an acquired pathology in the case of compression of the celiac artery by enlarged lymph nodes and neurofibrous tissue of the celiac plexus. In addition to hemodynamically significant disorders of blood supply to the gastrointestinal tract, Dunbar syndrome in children and adolescents is also accompanied by psycho-emotional disorders due to the presence of unstable stools, recurrent abdominal pain, and often repeated ineffective requests for medical care. Clinical observation, methods of diagnosis and surgical treatment of median arcuate ligament syndrome in a 14-year-old patient are presented in the study.
{"title":"Clinical case of median arcuate ligament syndrome in the practice of a pediatric surgeon","authors":"N. A. Surkov, O. M. Dondup, F. S. Piloyan, D. M. Redkina, A. A. Zaripova","doi":"10.34215/1609-1175-2024-1-79-81","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-79-81","url":null,"abstract":"Recurrent abdominal pain in childhood and adolescence may be indicative of chronic mesenteric ischemia with median arcuate ligament syndrome as a result of compression of the celiac artery by the median arcuate ligament of the diaphragm and its internal crura, neurofibrous tissue of the celiac plexus. The presence of symptoms characteristic of various diseases of gastrointestinal tract organs, absence of pathognomonic signs and complex approach in diagnostics of abdominal cavity vascular system, insufficient awareness of specialists of children’s outpatient clinics determine the urgency of timely diagnostics and treatment of patients with this pathology. Median arcuate ligament syndrome, or Dunbar syndrome, is more often a congenital malformation. This syndrome can be considered as an acquired pathology in the case of compression of the celiac artery by enlarged lymph nodes and neurofibrous tissue of the celiac plexus. In addition to hemodynamically significant disorders of blood supply to the gastrointestinal tract, Dunbar syndrome in children and adolescents is also accompanied by psycho-emotional disorders due to the presence of unstable stools, recurrent abdominal pain, and often repeated ineffective requests for medical care. Clinical observation, methods of diagnosis and surgical treatment of median arcuate ligament syndrome in a 14-year-old patient are presented in the study.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"30 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-72-74
A. F. Popov, V. Ivanis, V. I. Verkhoturova, E. V. Safronova, T. A. Kabantsevа, S. I. Yehlakov, V. А. Pavlov
The Far Eastern Federal District comprises an epidemic focus of hemorrhagic fever with renal syndrome (HFRS), where the incidence is determined by two orthohantaviruses: Hantaan (including its variant Amur) and Seoul. In Primorsky Krai, the average long-term incidence rate for 13 years (2011–2023) accounted for 2.7% (in some years up to 4.4% per 100 thousand population), and the mortality rate comprised 3.2% (9.1% in 2018). The distribution of clinical forms of the disease over the past 13 years revealed the prevalence of its moderate forms (66%), severe forms accounted for about 30% of all cases. The study presents a clinical case of severe course of HFRS with lethal outcome in a young male with no concomitant pathology.
{"title":"Fatal case of haemorrhagic fever with renal syndrome","authors":"A. F. Popov, V. Ivanis, V. I. Verkhoturova, E. V. Safronova, T. A. Kabantsevа, S. I. Yehlakov, V. А. Pavlov","doi":"10.34215/1609-1175-2024-1-72-74","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-72-74","url":null,"abstract":"The Far Eastern Federal District comprises an epidemic focus of hemorrhagic fever with renal syndrome (HFRS), where the incidence is determined by two orthohantaviruses: Hantaan (including its variant Amur) and Seoul. In Primorsky Krai, the average long-term incidence rate for 13 years (2011–2023) accounted for 2.7% (in some years up to 4.4% per 100 thousand population), and the mortality rate comprised 3.2% (9.1% in 2018). The distribution of clinical forms of the disease over the past 13 years revealed the prevalence of its moderate forms (66%), severe forms accounted for about 30% of all cases. The study presents a clinical case of severe course of HFRS with lethal outcome in a young male with no concomitant pathology.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"105 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-5-10
V. B. Shumatov, E. V. Prosekova, M. S. Dolgopolov, A. I. Turyanskaya, V. K. Kovalchuk, V. A. Sabynych
The present paper analyses genetic predictors of various endotypes and phenotypes of bronchial asthma in children. The review of data on the structure and prevalence of single-nucleotide polymorphisms of interleukin genes demonstrates their correlation with the risk of virus-induced and allergen-induced phenotypes of bronchial asthma. Significant differences in genotypes correlate with aberrant production of interleukin and the risks for developing various phenotypes of the disease. The studies into genetic factors indicate the significance of functional polymorphisms of interleukin genes as predictors associated with phenotypes and risk of the disease.
{"title":"Comparative characterization of interleukin genotypes and risks of bronchial asthma phenotypes in children","authors":"V. B. Shumatov, E. V. Prosekova, M. S. Dolgopolov, A. I. Turyanskaya, V. K. Kovalchuk, V. A. Sabynych","doi":"10.34215/1609-1175-2024-1-5-10","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-5-10","url":null,"abstract":"The present paper analyses genetic predictors of various endotypes and phenotypes of bronchial asthma in children. The review of data on the structure and prevalence of single-nucleotide polymorphisms of interleukin genes demonstrates their correlation with the risk of virus-induced and allergen-induced phenotypes of bronchial asthma. Significant differences in genotypes correlate with aberrant production of interleukin and the risks for developing various phenotypes of the disease. The studies into genetic factors indicate the significance of functional polymorphisms of interleukin genes as predictors associated with phenotypes and risk of the disease.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"113 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-24-28
A. N. Shilova, T. Zharikova, K. R. Koychuev, Yury O Zharikov, V. Nikolenko
The variant anatomy of the biliary tract and its sources of blood supply causes technical difficulties and increases the risk of damage to these main structures in the area of the porta hepatis and hepatoduodenal ligament during hepatobiliary operations, especially laparoscopic cholecystectomy. The main structures form a single topographic formation – the Calot’s triangle, with possible multiple anatomical variations, considered in the literature review.
{"title":"Variant anatomy of structures in Calot’s triangle","authors":"A. N. Shilova, T. Zharikova, K. R. Koychuev, Yury O Zharikov, V. Nikolenko","doi":"10.34215/1609-1175-2024-1-24-28","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-24-28","url":null,"abstract":"The variant anatomy of the biliary tract and its sources of blood supply causes technical difficulties and increases the risk of damage to these main structures in the area of the porta hepatis and hepatoduodenal ligament during hepatobiliary operations, especially laparoscopic cholecystectomy. The main structures form a single topographic formation – the Calot’s triangle, with possible multiple anatomical variations, considered in the literature review.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"110 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-39-42
Yu. V. Bykov, V. Baturin, A. P. Vorobyova, A. A. Vartanyan
Objective. To analyze the levels of antioxidant enzyme superoxide dismutase (SOD) and glutathione peroxidase (GP) against the background of diabetic ketoacidosis (DKA) in type 1 diabetes mellitus (DM) children and adolescents. Materials and methods. The study involved examination of 74 children: 50 DKA children (study group) and 24 relatively healthy children (control group). The study group children were divided into two subgroups: subgroup 1 included children with DKA against the background of type 1 DM onset (n=27), subgroup 2 consisted of children with DKA against the background of chronic type 1 DM (n=23). SOD and GP concentrations in blood plasma were determined in all children by enzyme immunoassay. The reliability between the data was estimated using the Mann-Whitney test, Kruskal-Wallis test and Spearman coefficient. Results. A significant decrease in SOD and GP in children with DKA was revealed as follows: 13130 [13005–18255] Pg/ml and 50.085 [42.02–70.325] Ng/ml, compared to controls: 16415 [13370–19935] Pg/ml and 84.695 [52.49–144.5] Ng/ml, respectively. Minimal SOD and GP were noted in patients with DKA at the background of chronic type 1 DM, compared to DM onset children. The study indicates a reliable correlation between age, duration of the disease, number of DKA in the history and low values of SOD and GP. Conclusion. Decreased antioxidant capacity was found in children with DKA in type 1 DM. SOD and GP can be considered in pediatric practice as markers of oxidative stress in DKA. In addition, an early detection of SOD and GP contributes to the efficient therapy of DKA in children and adolescents.
{"title":"Decreased antioxidant capacity in children with diabetic ketoacidosis","authors":"Yu. V. Bykov, V. Baturin, A. P. Vorobyova, A. A. Vartanyan","doi":"10.34215/1609-1175-2024-1-39-42","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-39-42","url":null,"abstract":"Objective. To analyze the levels of antioxidant enzyme superoxide dismutase (SOD) and glutathione peroxidase (GP) against the background of diabetic ketoacidosis (DKA) in type 1 diabetes mellitus (DM) children and adolescents. Materials and methods. The study involved examination of 74 children: 50 DKA children (study group) and 24 relatively healthy children (control group). The study group children were divided into two subgroups: subgroup 1 included children with DKA against the background of type 1 DM onset (n=27), subgroup 2 consisted of children with DKA against the background of chronic type 1 DM (n=23). SOD and GP concentrations in blood plasma were determined in all children by enzyme immunoassay. The reliability between the data was estimated using the Mann-Whitney test, Kruskal-Wallis test and Spearman coefficient. Results. A significant decrease in SOD and GP in children with DKA was revealed as follows: 13130 [13005–18255] Pg/ml and 50.085 [42.02–70.325] Ng/ml, compared to controls: 16415 [13370–19935] Pg/ml and 84.695 [52.49–144.5] Ng/ml, respectively. Minimal SOD and GP were noted in patients with DKA at the background of chronic type 1 DM, compared to DM onset children. The study indicates a reliable correlation between age, duration of the disease, number of DKA in the history and low values of SOD and GP. Conclusion. Decreased antioxidant capacity was found in children with DKA in type 1 DM. SOD and GP can be considered in pediatric practice as markers of oxidative stress in DKA. In addition, an early detection of SOD and GP contributes to the efficient therapy of DKA in children and adolescents.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"124 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-60-63
D. Sosnin, K. R. Galkovich
Objective. To determine the marker function of fatty acid binding protein (FABP) concentration in seminal plasma (SP) in order to assess ejaculate fertility used in in vitro fertilization (IVF) treatment of infertility in couples. Materials and methods. The study involved semen samples of 96 men of reproductive age: the study group (n=63) – patients with a decrease in concentration and/or total content of spermatozoa in ejaculate, the comparison group (n=33) – men with normal concentration and number of spermatozoa in ejaculate. The content of FABP in SP was determined by enzyme-linked immunosorbent assay using the test system “FABP – ELISA – BEST” (A-9102, Vector-Best, Russia). In order to determine the informative value of using the concentration of FABP in SP as a criterion of ejaculate fertility of men of the study group, the predictive value of positive and negative IVF results was determined by calculating the diagnostic sensitivity, specificity and efficiency. Results. The content of FABP in SP accounted for 1.29 ± 0.24 ng/mL, the median and interquartile range comprised 1.23 [1.13–1.35] ng/mL, ranging from 1.08 to 2.79 ng/mL. The study revealed statistically significant intergroup differences (Mann-Whitney test U=79.00; p=0.000016), a weak correlation between the level of FABP and the concentration of spermatozoa (R=0.578008) and their number in ejaculate (R=0.583599). The diagnostic sensitivity of the test for FABP in SP of the men of the study group accounted for 81.82%, specificity – 78.95%, efficiency – 80.95%. Conclusion. Seminal plasma FABP can act as a marker of spermatogenesis disorders. The study of this protein in ejaculate provides the accuracy of predicting the outcome of in vitro fertilization.
{"title":"Concentration of fatty acid binding protein as a new indicator of ejaculate fertility","authors":"D. Sosnin, K. R. Galkovich","doi":"10.34215/1609-1175-2024-1-60-63","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-60-63","url":null,"abstract":"Objective. To determine the marker function of fatty acid binding protein (FABP) concentration in seminal plasma (SP) in order to assess ejaculate fertility used in in vitro fertilization (IVF) treatment of infertility in couples. Materials and methods. The study involved semen samples of 96 men of reproductive age: the study group (n=63) – patients with a decrease in concentration and/or total content of spermatozoa in ejaculate, the comparison group (n=33) – men with normal concentration and number of spermatozoa in ejaculate. The content of FABP in SP was determined by enzyme-linked immunosorbent assay using the test system “FABP – ELISA – BEST” (A-9102, Vector-Best, Russia). In order to determine the informative value of using the concentration of FABP in SP as a criterion of ejaculate fertility of men of the study group, the predictive value of positive and negative IVF results was determined by calculating the diagnostic sensitivity, specificity and efficiency. Results. The content of FABP in SP accounted for 1.29 ± 0.24 ng/mL, the median and interquartile range comprised 1.23 [1.13–1.35] ng/mL, ranging from 1.08 to 2.79 ng/mL. The study revealed statistically significant intergroup differences (Mann-Whitney test U=79.00; p=0.000016), a weak correlation between the level of FABP and the concentration of spermatozoa (R=0.578008) and their number in ejaculate (R=0.583599). The diagnostic sensitivity of the test for FABP in SP of the men of the study group accounted for 81.82%, specificity – 78.95%, efficiency – 80.95%. Conclusion. Seminal plasma FABP can act as a marker of spermatogenesis disorders. The study of this protein in ejaculate provides the accuracy of predicting the outcome of in vitro fertilization.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"116 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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