在侵蚀性-萎缩性口腔扁平苔藓患者中比较含有 10%黑升麻的新型粘液贴片与 0.1% 曲安奈德的疗效:试点研究。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-05-26 DOI:10.1002/cre2.886
Atessa Pakfetrat, Zahra Delavarian, Mahshid Malakooti, Hossein Bagheri, Habibollah Esmaily, Mahsa Ghorbani, Pooya Saeedi
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引用次数: 0

摘要

研究目的本研究评估了含有 10%黑升麻提取物的新型粘液贴片与 0.1% 曲安奈德相比,在缓解侵蚀性-萎缩性口腔扁平苔藓患者症状和降低皮损严重程度方面的疗效:试验研究包括两组,每组 10 名患者。干预组使用含 10%荠菜提取物的粘液贴片,对照组使用 0.1% 曲安奈德贴片。通过视觉模拟量表测量疼痛和烧灼感的强度,并根据 Thongprasom 量表评估病变的严重程度,每周评估一次,持续 4 周。对副作用和患者满意度进行描述性记录:结果:在整个疗程中,两组患者的疼痛和灼烧感都有所减轻,其中藜芦组的减轻幅度大于曲安奈德组。各组的灼烧强度均有显著降低(P .05)。两组的皮损严重程度也都明显减轻(p 结论:N.Sativa 提取物和三苯氧胺组的皮损严重程度都明显减轻:在减轻口腔扁平苔藓患者的疼痛、灼烧感和皮损严重程度方面,粘贴贴片中的荠菜提取物与皮质类固醇同样有效,而且在某些疗程中荠菜提取物的效果更好。值得注意的是,使用 N. sativa 没有观察到明显的并发症,使其成为治疗扁平苔藓的一种很有前景的选择。
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Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study

Objective

This study evaluates the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive-atrophic oral lichen planus.

Methods and Materials

A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing N. sativa 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.

Results

Pain and burning intensity decreased in both groups throughout the sessions, with the N. sativa group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (p < .001), and there was a significant difference between groups only in the second session (p = .045). The overall difference between groups was not significant (p > .05). Lesion severity also decreased significantly in both groups (p < .001), with a significant difference between groups observed in the third session (p = .043) and overall throughout the study (p = .006).

Conclusion

The use of N. sativa extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with N. sativa showing superior results in some sessions. Notably, no significant complications were observed with N. sativa use, making it a promising treatment option for lichen planus.

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来源期刊
Clinical and Experimental Dental Research
Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.60%
发文量
165
审稿时长
26 weeks
期刊介绍: Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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