胎膜早破与阴道微生物群的变化 - 益生菌

IF 2.5 3区 生物学 Q3 REPRODUCTIVE BIOLOGY Reproductive biology Pub Date : 2024-05-27 DOI:10.1016/j.repbio.2024.100899
Kamila Gorczyca , Małgorzata M. Kozioł , Żaneta Kimber-Trojnar , Joanna Kępa , Małgorzata Satora , Anna K. Rekowska , Bożena Leszczyńska-Gorzelak
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引用次数: 0

摘要

全世界约有 1 500 万名妇女早产,其中 30% 是由于胎膜早破(PPROM)造成的。造成妊娠期缩短的原因包括遗传、荷尔蒙、免疫和社会经济条件。近年来,微生物群和整个微生物组对孕妇的影响提供了大量证据,表明栖息在阴道中的微生物对早产风险有显著影响。本研究旨在回顾评估阴道微生物菌群的组成及其在 PPROM 引起的早产发生中所起作用的研究,并评估益生菌对预防早产发生的潜在有益作用。阴道微生物菌群失调可在早产儿中观察到,由于它与早产和感染的高风险有关,会增加新生儿的发病率和死亡率。进一步研究用于筛查、早期预后和诊断 PPROM 的生物标志物似乎是明智的。益生菌作为一种潜在的干预措施,可以预防病理性阴道菌群的发展,降低计划怀孕妇女和孕妇的感染风险。
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Premature rupture of membranes and changes in the vaginal microbiome – Probiotics

Preterm birth affects approximately 15 million women worldwide, of which 30 % is due to preterm premature rupture of membranes (PPROM). The reasons for shortening the duration of pregnancy are seen in genetic, hormonal, immunological and socio-economic conditions. Recent years have provided a lot of evidence on the impact of the microbiota and whole microbiome on pregnant women, suggesting that the microorganisms inhabiting the vagina significantly affect the risk of preterm delivery. The aim of the study was to review studies evaluating the composition of the vaginal microflora and its role in the occurrence of preterm labor caused by PPROM, and to evaluate the potential beneficial effect of probiotics on preventing the development of preterm labor. Vaginal microbial dysbiosis is observed in PPROM, which, due to its association with a high risk of prematurity and infection, increases neonatal morbidity and mortality. Further research on biomarkers for screening, early prognosis and diagnosis of PPROM seems advisable. Probiotics as a potential intervention can prevent the development of pathological vaginal flora, reducing the risk of infection in women planning pregnancy and pregnant women.

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来源期刊
Reproductive biology
Reproductive biology 生物-生殖生物学
CiteScore
3.90
自引率
0.00%
发文量
95
审稿时长
29 days
期刊介绍: An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn, Poland. Reproductive Biology is an international, peer-reviewed journal covering all aspects of reproduction in vertebrates. The journal invites original research papers, short communications, review articles and commentaries dealing with reproductive physiology, endocrinology, immunology, molecular and cellular biology, receptor studies, animal breeding as well as andrology, embryology, infertility, assisted reproduction and contraception. Papers from both basic and clinical research will be considered.
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