饮食和生活方式因素对肥胖者炎症指标(IL-6、IFN-γ 和 TNF-α)水平的影响。

IF 1.5 4区 医学 Q4 IMMUNOLOGY Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-04-15 DOI:10.5114/ceji.2024.138748
Ewelina Polak-Szczybyło, Jacek Tabarkiewicz
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引用次数: 0

摘要

引言肥胖者体内的低度炎症会导致多种疾病,包括心血管疾病(CVD)。均衡饮食中的膳食模式、食物种类或营养成分可降低促炎症标志物的水平,减少与肥胖相关的发病风险。我们的研究旨在描述肥胖患者体内的三种细胞因子与饮食习惯、生活方式和身体成分的关系:收集了 84 名肥胖成年志愿者[体重指数(BMI)≥ 30 kg/m2]的血清样本,以分析白细胞介素 6(IL-6)、肿瘤坏死因子α(TNF-α)和干扰素γ(IFN-γ)的浓度。受试者接受了生物电阻抗分析(BIA)测试,并完成了为期三天的食物日记和原始问卷与 FFQ-6 食物消费频率问卷:结果和结论:发现动脉粥样硬化患者血清中的 IL-6 和 IFN-γ 水平较高,但由于群体太小,无法得出可靠的相关性。皮下脂肪组织而非内脏脂肪组织与 IL-6 水平呈正相关。饮食因素,如饮食中糖(包括半乳糖和蔗糖)的含量以及食用甜味乳制品的频率与 IL-6 和 TNF-α 的水平呈正相关,而饮酒频率与 IL-6 的水平呈负相关。运动频率越高,IL-6 水平越高。在肥胖者中,促炎细胞因子的水平可能导致动脉粥样硬化,并与饮食因素和生活方式有关。
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Influence of dietary and lifestyle factors on levels of inflammatory markers (IL-6, IFN-γ and TNF-α) in obese subjects.

Introduction: The low-grade inflammation occurring in obese individuals leads to many diseases, including cardiovascular disease (CVD). Dietary patterns, food groups or nutrients in a well-balanced diet may reduce the level of pro-inflammatory markers and the risk of obesity-related morbidities. Our study aims to describe three cytokines in obese patients in relation to dietary habits, lifestyle and body composition.

Material and methods: Serum samples were collected from 84 obese adult volunteer subjects [body mass index (BMI) ≥ 30 kg/m2] to analyze the concentrations of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and interferon γ (IFN-γ). The subjects were tested by bioelectrical impedance analysis (BIA) and completed a three-day food diary and original questionnaire with the FFQ-6 food consumption frequency questionnaire.

Results and conclusions: Higher serum levels of IL-6 and IFN-γ were found in patients with atherosclerosis, but the group was too small for a reliable correlation. Subcutaneous but not visceral adipose tissue correlated positively with IL-6 levels. Dietary factors such as amount of sugars, including galactose and sucrose, in the diet and the frequency of consumption of sweet flavored dairy products correlated positively with the levels of IL-6 and TNF-α, while the frequency of alcohol consumption negatively correlated with the level of IL-6. The greater the frequency of sports, the higher was the level of IL-6. In obese individuals, the level of pro-inflammatory cytokines could predispose to atherosclerosis and is associated with dietary factors and lifestyle.

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来源期刊
CiteScore
3.00
自引率
0.00%
发文量
17
审稿时长
6-12 weeks
期刊介绍: Central European Journal of Immunology is a English-language quarterly aimed mainly at immunologists.
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