通过 2-甲酰基苯硼酸与酰胺的 Chan-Evans-Lam 偶联合成 2-芳基喹唑啉类化合物

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-05 DOI:10.1007/s10593-024-03314-2

Vitalii V. Solomin, Darija Zaharova, Aigars Jirgensons

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引用次数: 0

摘要

本文介绍了一种合成 2-芳基喹唑啉的方法，该方法涉及 2-甲酰基苯硼酸与胺的 Chan-Evans-Lam 偶联。该反应在温和的条件下进行，与官能团的范围相适应，并通过使用廉价的催化剂和试剂实现成本效益。所介绍的 2-芳基喹唑啉的合成方法适用于 2-甲酰基苯硼酸和脒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 2-arylquinazolines by Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines

A method for the synthesis of 2-arylquinazolines is described which involves Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines. The reaction is performed at mild conditions compatible with the range of functional groups and is cost-efficient, provided by usage of inexpensive catalyst and reagents. The synthesis method of 2-arylquinazolines presented is of with scope in both 2-formylphenylboronic acids and amidines.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.