Alstonia boonei De Wild(Apocynaceae)的水提取物可减轻氧化棕榈油和蔗糖补充剂诱发的大鼠骨代谢紊乱

Nadine Florence Ambomo, R. Gounoue, J. Donfack, F. Ngueguim, Angèle Carine Bidja, P. Dzeufiet, T. Dimo
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引用次数: 0

摘要

背景:营养不良会破坏骨代谢,导致骨折。本研究调查了 Alstonia boonei 的水性叶提取物对以氧化棕榈油和蔗糖为辅食的骨折大鼠的影响。研究方法测定氧化棕榈油的碘、过氧化物和酸度指数。用富含氧化棕榈油和蔗糖的食物喂养大鼠 16 周,诱发骨骼损伤,然后造成骨折。骨折动物在饮食中同时摄入蒸馏水或植物提取物(50、100 或 200 毫克/千克),为期两周。对生化指标进行了评估,包括脂质概况、骨标志物、氧化应激和血液学指标。对股骨进行了 X 射线检查和组织学检查。结果显示氧化棕榈油的过氧化物指数和酸度指数显著增加,而碘指数下降。以富含氧化棕榈油和蔗糖的食物喂养的骨折大鼠表现出血脂异常、血液学参数改变、氧化应激骨 ALP 活性和自然骨形成不良。骨折导致骨钙减少,骨 ALP 增加。A. boonei 提取物改善了血脂、血液学和氧化应激参数。股骨钙明显增加,股骨 ALP 明显降低。此外,还观察到骨结构的更好组织,剂量为 100 毫克/千克时效果明显。结论这些结果表明,A. boonei叶能改善营养不良条件下的骨修复,这要归功于其提取物中的矿物质和次生代谢产物所具有的降血脂和抗氧化特性。
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Aqueous extract of Alstonia boonei De Wild (Apocynaceae) alleviates bone metabolism disorders induced by oxidised palm oil and sucrose supplementation in rats
Background: Poor nutritional status disrupts bone metabolism leading to fractures. This study investigated the effect of the aqueous leaf extract of Alstonia boonei on fractured rats fed a diet supplemented with oxidised palm oil and sucrose. Methods: The iodine, peroxide and acidity indexes of the oxidised palm oil were determined. Bone damage was induced by feeding rats an oxidised palm oil/sucrose enriched diet for 16 weeks followed by fracture. Fractured animals received distilled water or plant extract (50, 100 or 200 mg/kg) simultaneously with their diet for two weeks. Biochemical parameters including lipid profile, bone markers, oxidative stress and hematological parameters were assessed. X-rays and histology of the femur were performed. Results: Oxidised palm oil showed a significant increase in the peroxide and acidity indexes, while the iodine index decreased. Fractured rats fed a diet enriched with oxidised palm oil and sucrose exhibited dyslipidemia, altered haematological parameters and oxidative stress bone ALP activity with poor natural bone formation. Fracture induced a decrease in bone calcium and an increase in bone ALP. A. boonei extract improved lipid profile, hematological and oxidative stress parameters. There was a significant increase in femoral calcium and a significant decrease in femoral ALP. In addition, a better organisation of the bone architecture was observed, with a marked effect at a dose of 100 mg/kg. Conclusion: These results suggest that A. boonei leaf improves bone repair in poor nutritional conditions, thanks to its hypolipidemic and antioxidant properties mediated by the minerals and secondary metabolites contained in the extract.
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