运动依赖症患者的大脑变化:多模态神经影像学调查。

IF 6.6 1区 医学 Q1 PSYCHIATRY Journal of Behavioral Addictions Pub Date : 2024-06-05 Print Date: 2024-06-26 DOI:10.1556/2006.2024.00028
Anna-Chiara Schaub, Maximilian Meyer, Amos Tschopp, Aline Wagner, Undine E Lang, Marc Walter, Flora Colledge, André Schmidt
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引用次数: 0

摘要

背景:运动依赖(ED)的特征是行为和心理症状与药物使用障碍相似。然而,运动依赖是否伴有与药物使用障碍相似的脑部改变,目前仍无定论。因此,我们研究了ED患者和非活动对照参与者的大脑变化:在这项横断面神经影像学调查中,29 名通过运动依赖量表(EDS)评估的 ED 患者和 28 名非运动型对照组参与者(每周最多运动一小时)接受了结构性和功能性静息态磁共振成像(MRI)检查。研究人员使用基于体素的形态计量学和功能连通性分析探讨了组间差异。分析仅限于纹状体、杏仁核和额叶下回(IFG)。探索性分析测试了大脑结构和功能之间的关系是否与各组的 EDS 分量表有不同的关系:结果:两组之间未发现结构差异。然而,两组间右侧 IFG 和双侧 Putamen 的体积分别与 EDS 分量表 "时间 "和 "耐受性 "的关系不同。与非活动对照组相比,ED患者从右侧IFG到右侧上顶叶的静息状态功能连接性增强。此外,角回与左侧IFG和双侧尾状体的功能连接与EDS分量表 "耐受性 "的关系在不同组间存在差异:讨论:研究结果表明,ED可能伴随着与认知相关的大脑结构的改变,但也可能伴随着驱动强迫性习惯行为的功能变化。需要进一步开展前瞻性研究,以区分 ED 对大脑的有益和有害影响。
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Brain alterations in individuals with exercise dependence: A multimodal neuroimaging investigation.

Background: Exercise dependence (ED) is characterised by behavioural and psychological symptoms that resemble those of substance use disorders. However, it remains inconclusive whether ED is accompanied by similar brain alterations as seen in substance use disorders. Therefore, we investigated brain alterations in individuals with ED and inactive control participants.

Methods: In this cross-sectional neuroimaging investigation, 29 individuals with ED as assessed with the Exercise Dependence Scale (EDS) and 28 inactive control participants (max one hour exercising per week) underwent structural and functional resting-state magnetic resonance imaging (MRI). Group differences were explored using voxel-based morphometry and functional connectivity analyses. Analyses were restricted to the striatum, amygdala, and inferior frontal gyrus (IFG). Exploratory analyses tested whether relationships between brain structure and function were differently related to EDS subscales among groups.

Results: No structural differences were found between the two groups. However, right IFG and bilateral putamen volumes were differently related to the EDS subscales "time" and "tolerance", respectively, between the two groups. Resting-state functional connectivity was increased from right IFG to right superior parietal lobule in individuals with ED compared to inactive control participants. Furthermore, functional connectivity of the angular gyrus to the left IFG and bilateral caudate showed divergent relationships to the EDS subscale "tolerance" among groups.

Discussion: The findings suggest that ED may be accompanied by alterations in cognition-related brain structures, but also functional changes that may drive compulsive habitual behaviour. Further prospective studies are needed to disentangle beneficial and detrimental brain effects of ED.

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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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