母体和脐带血炎症标志物及 BDNF 与脑磁图记录的胎儿大脑活动的相关性:探索性研究

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-06-11 DOI:10.1016/j.bbih.2024.100804
Luis Mercado , Shannon Rose , Diana Escalona-Vargas , Nafisa Dajani , Eric R. Siegel , Hubert Preissl , Hari Eswaran
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引用次数: 0

摘要

背景在妊娠期间,胎儿的大脑发育受到许多生物标志物的影响,其中炎症过程和神经营养因子在过去十年中尤其受到关注。这项探索性研究首次尝试探讨母体和脐带血样本中的生物标记物水平与非侵入性胎儿脑磁图(fMEG)测量的胎儿大脑活动之间的关系。其中 12 名产妇患有糖尿病。分娩时还采集了脐带血。测量了母体和脐带血中的生物标记物水平,随后分析了从 fMEG 功率谱密度中提取的四个频段与胎儿大脑活动的相关性。结果δ、α和β频段的相对功率与母体 BDNF 和脐带血 CRP 水平在调整糖尿病状态之前和之后均表现出中等程度的相关性。δ频段呈负相关,α和β频段呈正相关。母体 CRP 和脐血 BDNF 及 IL-6 与所有四个波段的相对功率的相关性微乎其微。结论母体BDNF水平和脐血CRP水平似乎与胎儿的大脑活动直接相关。我们的研究结果表明,这些生物标志物可与胎儿脑电生理学结合使用,以追踪胎儿的神经发育情况。
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Correlating maternal and cord-blood inflammatory markers and BDNF with human fetal brain activity recorded by magnetoencephalography: An exploratory study

Background

During gestation, the brain development of the fetus is affected by many biological markers, where inflammatory processes and neurotrophic factors have been of particular interest in the past decade.

Aim

This exploratory study is the first attempt to explore the relationships between biomarker levels in maternal and cord-blood samples and human fetal brain activity measured with non-invasive fetal magnetoencephalography (fMEG).

Method

Twenty-three women were enrolled in this study for collection of maternal serum and fMEG tracings immediately prior to their scheduled cesarean delivery. Twelve of these women had a preexisting diabetic condition. At the time of delivery, umbilical cord blood was also collected. Biomarker levels from both maternal and cord blood were measured and subsequently analyzed for correlations with fetal brain activity in four frequency bands extracted from fMEG power spectral densities.

Results

Relative power in the delta, alpha, and beta frequency bands exhibited moderate-sized correlations with maternal BDNF and cord-blood CRP levels before and after adjusting for confounding diabetic status. These correlations were negative for the delta band, and positive for the alpha and beta bands. Maternal CRP and cord-blood BDNF and IL-6 exhibited negligible correlations with relative power in all four bands. Diabetes did not appear to be a strong confounding factor affecting the studied biomarkers.

Conclusions

Maternal BDNF levels and cord-blood CRP levels appear to have a direct correlation to fetal brain activity. Our findings indicate the potential use of these biomarkers in conjunction with fetal brain electrophysiology to track fetal neurodevelopment.

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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
97 days
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