间歇性禁食和高强度间歇训练不会改变肥胖成年女性的肠道微生物群组成。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM American journal of physiology. Endocrinology and metabolism Pub Date : 2024-09-01 Epub Date: 2024-06-26 DOI:10.1152/ajpendo.00310.2023
Gabriela Batitucci, Otávio G Almeida, Elaine C P De Martinis, Isabela Solar, Dennys E Cintra, Ellen Cristini de Freitas
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引用次数: 0

摘要

肥胖症正在加速发展,但其治疗仍是一个新兴领域。尽管已有研究表明微生物群在肥胖症发病机制中的作用,但这是第一项显示间歇性禁食(IF)结合或不结合运动(HIIT)对肥胖女性肠道微生物群组成影响的研究。我们的假设是,间歇性禁食结合 HIIT 可以促进肠道微生物群组成和功能的重塑。36名年龄在18至40岁之间的肥胖症女性参与了这项研究,她们被随机分为3组:1)IF与HIIT组(IF+EX,n = 15);2)HIIT组(EX,n = 11);3)IF组(IF,n = 10)。干预为期 8 周,所有评估均在干预前后进行。HIIT 循环训练每周进行 3 次,每次 25 分钟。IF 方案为 5:2(2 次/周)。对炎症细胞因子进行了多重分析,对 16S rRNA 基因进行了测序,并采用气相色谱法测量了粪便中短链脂肪酸 (SCFA) 的浓度。该研究已在 ClinicalTrials.gov 上注册(NCT05237154)。运动增加了粪便中乙酸盐浓度(P = 0.04),但未观察到微生物群的组成和功能特征发生变化。干预措施没有改变微生物群的组成,但运动可能对醋酸盐的产生起到调节作用。这项研究为肥胖妇女使用 IF 和 HIIT 提供了临床启示。
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Intermittent fasting and high-intensity interval training do not alter gut microbiota composition in adult women with obesity.

Obesity is advancing at an accelerated pace, and yet its treatment is still an emerging field. Although studies have demonstrated the role of the microbiota in the pathogenesis of obesity, this is the first study to show the effects of intermittent fasting (IF), combined or not with exercise, and high-intensity interval training (HIIT) on the gut microbiota composition in women with obesity. Our hypothesis is that IF combined with HIIT can promote the remodeling of the composition and function of the gut microbiota. Thirty-six women with obesity, aged between 18 and 40 yr, participated in the study. They were randomly divided into three groups: 1) IF associated with HIIT group [IF + exercise group (EX), n = 15]; 2) HIIT group (EX, n = 11); and 3) IF group (IF, n = 10). Interventions took place over 8 wk, and all assessments were performed preintervention and postintervention. The HIIT circuit was performed 3 times/wk, for 25 min/session. The IF protocol was a 5:2 (2 times/wk). Multiplex analysis of inflammatory cytokines, sequencing of the 16S rRNA gene, and gas chromatography to measure fecal concentrations of short-chain fatty acids (SCFAs) were performed. This study was registered on ClinicalTrials.gov (NCT05237154). Exercise increased fecal acetate concentrations (P = 0.04), but no changes were observed in the composition and functional profile of the microbiota. The interventions did not change the composition of the microbiota, but exercise may play a modulatory role in the production of acetate. This investigation provides clinical insights into the use of IF and HIIT for women with obesity.NEW & NOTEWORTHY This is the first investigation about alternate-day fasting combined with HITT on the gut microbiota of obese women. The study contributes to the advancement of human science involving IF and HIIT, popular strategies for managing obesity. Previous evidence has explored IF in modulating the microbiota in animal models or specific populations and clinical conditions. Despite the subtle outcomes, this study has relevance and originality in the field of gut microbiota knowledge.

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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
98
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.
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