对五十六个大动脉血管网络中的脑血流进行静态和动态分析。

IF 2.3 4区 医学 Q3 BIOPHYSICS Physiological measurement Pub Date : 2024-07-12 DOI:10.1088/1361-6579/ad5bbb
Yuan-Chung Chou, Stephen Payne
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引用次数: 0

摘要

目的:脑血管是由许多不同长度尺度的血管组成的复杂网络。其结构和连接的变化与多种脑血管和神经系统疾病有关。在这项研究中,我们提出了一种在大型数据集中使用计算和数学工具对脑血管进行定量分析的新方法。我们分析了一个公开的血管数据集,该数据集来自一组 56 名(32/24 名女性/男性)健康受试者。该数据集包括人脑大血管的数字重建。然后,我们提出了一个新的数学模型来计算这 56 个具有代表性的大脑大血管内的血流动态和压力分布,并对整个组群的结果进行量化。统计分析显示,男性和女性的脑血管阻力(CVR)稳态水平都会随着年龄的增长而逐渐增加。这些与年龄有关的 CVR 变化与之前报道的数值非常吻合。所有受试者的血压与心频血流之间的相位角都很小(< 6°)。这些结果表明,血流的动态成分在心脏频率上增加的相移很小,这意味着至少在健康人群中,不论年龄或性别,大脑大循环的行为可被视为接近稳态。这意味着在脑血管血流测量中观察到的相移是由血管床更下方的行为引起的。这种行为对于未来建立动态维持大脑氧气和营养供应的统计模型非常重要。
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Static and dynamic analysis of cerebral blood flow in fifty-six large arterial vessel networks.

Objective.The cerebral vasculature is formed of an intricate network of blood vessels over many different length scales. Changes in their structure and connection are implicated in multiple cerebrovascular and neurological disorders. In this study, we present a novel approach to the quantitative analysis of the cerebral macrovasculature using computational and mathematical tools in a large dataset.Approach.We analysed a publicly available vessel dataset from a cohort of 56 (32/24F/M) healthy subjects. This dataset includes digital reconstructions of human brain macrovasculatures. We then propose a new mathematical model to compute blood flow dynamics and pressure distributions within these 56-representative cerebral macrovasculatures and quantify the results across this cohort.Main results.Statistical analysis showed that the steady state level of cerebrovascular resistance (CVR) gradually increases with age in both men and women. These age-related changes in CVR are in good agreement with previously reported values. All subjects were found to have only small phase angles (<6°) between blood pressure and blood flow at the cardiac frequency.Significance.These results showed that the dynamic component of blood flow adds very little phase shift at the cardiac frequency, which implies that the cerebral macrocirculation can be regarded as close to steady state in its behaviour, at least in healthy populations, irrespective of age or sex. This implies that the phase shift observed in measurements of blood flow in cerebral vessels is caused by behaviour further down the vascular bed. This behaviour is important for future statistical models of the dynamic maintenance of oxygen and nutrient supply to the brain.

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来源期刊
Physiological measurement
Physiological measurement 生物-工程:生物医学
CiteScore
5.50
自引率
9.40%
发文量
124
审稿时长
3 months
期刊介绍: Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.
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