生物活性链霉菌:合成具有多种特性的纳米粒子的有力工具

IF 3.5 4区 生物学 Q2 MICROBIOLOGY Journal of Basic Microbiology Pub Date : 2024-06-23 DOI:10.1002/jobm.202400129
Muhammad Sultan Anjum, Shazia Khaliq, Neelma Ashraf, Munir Ahmad Anwar, Kalsoom Akhtar
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引用次数: 0

摘要

纳米生物技术因其通过整合微生物生物技术和纳米技术产生巨大效益的能力而备受关注。在微生物中,放线菌,尤其是著名的链霉菌属,因其大量生产抗生素而备受关注。链霉菌是发现大量抗生素的关键贡献者,在全球范围内抗击传染性疾病方面发挥着主导作用。尽管通过开发和利用抗生素来抗击传染病病原体取得了显著进展,但传染病的流行仍然是全球死亡的主要原因,尤其是在老人和儿童中。近几十年来,病原体对抗生素产生的抗药性削弱了抗生素的功效。尽管如此,链霉菌仍通过产生生物活性代谢物来合成纳米粒子,从而继续展示其潜力。链霉菌有助于生产具有多种生物活性特性的纳米粒子,包括抗病毒、抗菌、抗真菌、抗氧化和抗肿瘤特性。生物合成的纳米粒子大大减少了抗生素耐药性的影响,为开发新的有效药物提供了资源。这篇综述简明扼要地概述了链霉菌作为纳米粒子合成的关键元素的重要应用,展示了它们在多样化和增强有益应用方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Bioactive Streptomycetes: A Powerful Tool to Synthesize Diverse Nanoparticles With Multifarious Properties

Nanobiotechnology has gained significant attention due to its capacity to generate substantial benefits through the integration of microbial biotechnology and nanotechnology. Among microbial organisms, Actinomycetes, particularly the prominent genus Streptomycetes, have garnered attention for their prolific production of antibiotics. Streptomycetes have emerged as pivotal contributors to the discovery of a substantial number of antibiotics and play a dominant role in combating infectious diseases on a global scale. Despite the noteworthy progress achieved through the development and utilization of antibiotics to combat infectious pathogens, the prevalence of infectious diseases remains a prominent cause of mortality worldwide, particularly among the elderly and children. The emergence of antibiotic resistance among pathogens has diminished the efficacy of antibiotics in recent decades. Nevertheless, Streptomycetes continue to demonstrate their potential by producing bioactive metabolites for the synthesis of nanoparticles. Streptomycetes are instrumental in producing nanoparticles with diverse bioactive characteristics, including antiviral, antibacterial, antifungal, antioxidant, and antitumor properties. Biologically synthesized nanoparticles have exhibited a meaningful reduction in the impact of antibiotic resistance, providing resources for the development of new and effective drugs. This review succinctly outlines the significant applications of Streptomycetes as a crucial element in nanoparticle synthesis, showcasing their potential for diverse and enhanced beneficial applications.

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来源期刊
Journal of Basic Microbiology
Journal of Basic Microbiology 生物-微生物学
CiteScore
6.10
自引率
0.00%
发文量
134
审稿时长
1.8 months
期刊介绍: The Journal of Basic Microbiology (JBM) publishes primary research papers on both procaryotic and eucaryotic microorganisms, including bacteria, archaea, fungi, algae, protozoans, phages, viruses, viroids and prions. Papers published deal with: microbial interactions (pathogenic, mutualistic, environmental), ecology, physiology, genetics and cell biology/development, new methodologies, i.e., new imaging technologies (e.g. video-fluorescence microscopy, modern TEM applications) novel molecular biology methods (e.g. PCR-based gene targeting or cassettes for cloning of GFP constructs).
期刊最新文献
Establishing an Interactive Sequence Database for Shiitake Cultivar Identification. Cover: Journal of Basic Microbiology. 11/2024 Issue Information: Journal of Basic Microbiology. 11/2024 Role of Orphan ParA Proteins in Replication and Cell Division in Rhodococcus erythropolis PR4. Biocatalytic Potential of Pseudomonas Species in the Degradation of Polycyclic Aromatic Hydrocarbons.
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