手性解析的新方法:加压-CO2 辅助优先共晶体化

IF 3.4 3区 工程技术 Q2 CHEMISTRY, PHYSICAL Journal of Supercritical Fluids Pub Date : 2024-06-24 DOI:10.1016/j.supflu.2024.106339
Joséphine de Meester , Patrick Layrisse , Mathieu Marchivie , Laurent Collard , Guillaume Wery , Clément Brandel , Yohann Cartigny , Pascale Subra-Paternault , Tom Leyssens , Christelle Harscoat-Schiavo
{"title":"手性解析的新方法:加压-CO2 辅助优先共晶体化","authors":"Joséphine de Meester ,&nbsp;Patrick Layrisse ,&nbsp;Mathieu Marchivie ,&nbsp;Laurent Collard ,&nbsp;Guillaume Wery ,&nbsp;Clément Brandel ,&nbsp;Yohann Cartigny ,&nbsp;Pascale Subra-Paternault ,&nbsp;Tom Leyssens ,&nbsp;Christelle Harscoat-Schiavo","doi":"10.1016/j.supflu.2024.106339","DOIUrl":null,"url":null,"abstract":"<div><p>We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO<sub>2</sub> as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO<sub>2</sub>. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"212 ","pages":"Article 106339"},"PeriodicalIF":3.4000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization\",\"authors\":\"Joséphine de Meester ,&nbsp;Patrick Layrisse ,&nbsp;Mathieu Marchivie ,&nbsp;Laurent Collard ,&nbsp;Guillaume Wery ,&nbsp;Clément Brandel ,&nbsp;Yohann Cartigny ,&nbsp;Pascale Subra-Paternault ,&nbsp;Tom Leyssens ,&nbsp;Christelle Harscoat-Schiavo\",\"doi\":\"10.1016/j.supflu.2024.106339\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO<sub>2</sub> as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO<sub>2</sub>. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.</p></div>\",\"PeriodicalId\":17078,\"journal\":{\"name\":\"Journal of Supercritical Fluids\",\"volume\":\"212 \",\"pages\":\"Article 106339\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Supercritical Fluids\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0896844624001748\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Supercritical Fluids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0896844624001748","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0

摘要

我们在此报告了首次出现的由压缩二氧化碳辅助的优先共晶过程。我们的研究重点是奈非拉西坦-扁桃酸结晶体系。在所谓的 GAS 过程中,以压缩二氧化碳作为反溶剂,以丙酮、乙酸乙酯或异丁醇作为起始溶液的溶剂,成功地结晶出了共晶体凝聚体。然后,我们将重点放在丙酮上,在压缩 CO 的支持下成功实现了优先共晶。该工艺设计的关键步骤是调整装置,以便在反应器内引入对映体纯种。在使用种子环的基础上,我们测试了几种种子配置,通过两种对映体在反应器的两个不同区域同时结晶来提高对映体分离效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization

We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO2 as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO2. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Supercritical Fluids
Journal of Supercritical Fluids 工程技术-工程:化工
CiteScore
7.60
自引率
10.30%
发文量
236
审稿时长
56 days
期刊介绍: The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.
期刊最新文献
Exploring the potential of supercritical carbon dioxide for eugenol impregnation in 3D printed polylactic acid structures Extraction and isomerization of ultraviolet-absorbing substances, saclipins, from an edible cyanobacterium Aphanothece sacrum using subcritical water Supercritical fluid extraction of yerba mate: Decaffeination, purification, encapsulation, and controlled release Surface wettability of lignin materials from supercritical water hydrolysis of wood High-purity κ-carrageenan from Kappaphycus alvarezii algae for aerogel production by supercritical CO2 drying
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1