手性解析的新方法:加压-CO2 辅助优先共晶体化

IF 3.4 3区 工程技术 Q2 CHEMISTRY, PHYSICAL Journal of Supercritical Fluids Pub Date : 2024-06-24 DOI:10.1016/j.supflu.2024.106339
Joséphine de Meester , Patrick Layrisse , Mathieu Marchivie , Laurent Collard , Guillaume Wery , Clément Brandel , Yohann Cartigny , Pascale Subra-Paternault , Tom Leyssens , Christelle Harscoat-Schiavo
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引用次数: 0

摘要

我们在此报告了首次出现的由压缩二氧化碳辅助的优先共晶过程。我们的研究重点是奈非拉西坦-扁桃酸结晶体系。在所谓的 GAS 过程中,以压缩二氧化碳作为反溶剂,以丙酮、乙酸乙酯或异丁醇作为起始溶液的溶剂,成功地结晶出了共晶体凝聚体。然后,我们将重点放在丙酮上,在压缩 CO 的支持下成功实现了优先共晶。该工艺设计的关键步骤是调整装置,以便在反应器内引入对映体纯种。在使用种子环的基础上,我们测试了几种种子配置,通过两种对映体在反应器的两个不同区域同时结晶来提高对映体分离效果。
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Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization

We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO2 as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO2. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.

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来源期刊
Journal of Supercritical Fluids
Journal of Supercritical Fluids 工程技术-工程:化工
CiteScore
7.60
自引率
10.30%
发文量
236
审稿时长
56 days
期刊介绍: The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.
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