Journal of Supercritical Fluids最新文献

Statistical analysis of transient density field data of supercritical CO2 flow inside a local-heated channel from high-speed interferometer measurement 高速干涉仪测量局部加热通道内超临界CO2流动瞬态密度场数据的统计分析

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-07-01 Epub Date: 2026-02-10 DOI: 10.1016/j.supflu.2026.106927

Gang Zeng , Hao Huang , Zhaojia Liang , Lin Chen , Yanping Huang

For high-speed supercritical fluid turbulent flows, both boundary thermal perturbations and turbulent fluctuations introduce strong boundary-layer instabilities, giving rise to localized fluctuations that markedly influence boundary-layer development and heat transfer efficiency. In this study, a high-speed interferometer system was employed to capture the rapid evolution of turbulent heat-transfer transition processes and statistical analysis of the transient density field was conducted. Under a steady turbulent background, small-scale thermal disturbances were introduced, stimulating the rapid amplification of boundary stripes and the emergence of wave structures in both streamwise and wall-normal directions. Interferometric images were processed via Fourier transform (FT) and spatial carrier phase-shift (SCPS) methods, yielding quantitative local density fields. Based on Reynolds and temporal averaging, instantaneous quantities were decomposed into mean and fluctuating components, from which a statistical framework incorporating both spatial and temporal evolutionary features was established. Results show strong thermal expansion and convection enhance turbulence, with disturbance amplitudes of ±0.04 kg/m³ near the wall—larger than in the bulk flow. At low heat flux (2014 W/m²), inertia dominates and disturbances remain weak, whereas high flux (14057 W/m²) yields sharp gradients (∼0.6 kg/m³) and buoyancy-driven instabilities. The temporal evolution of boundary-layer convection reveals a transition from conduction-to-convection-dominated heat transfer, governed by buoyancy–mainstream coupling and shear-turbulence enhancement. Local thermal perturbations exhibit nonlinear amplification due to thermo-compressibility, intensified density gradients, turbulence–disturbance feedback, and buoyancy-induced shear-layer destabilization.

对于高速超临界流体湍流，边界热扰动和湍流起伏都会引入较强的边界层不稳定性，从而产生局部波动，显著影响边界层的发展和换热效率。本研究采用高速干涉仪系统捕捉湍流换热转变过程的快速演变，并对瞬态密度场进行统计分析。在稳定的湍流背景下，引入了小尺度的热扰动，刺激了边界条纹的快速放大和沿流方向和壁面法向波浪结构的出现。通过傅里叶变换（FT）和空间载波相移（SCPS）方法对干涉图像进行处理，得到定量的局部密度场。基于Reynolds和时间平均，将瞬时量分解为平均分量和波动分量，并以此为基础建立了一个兼具时空演化特征的统计框架。结果表明：强热膨胀和对流增强了紊流，壁面附近的扰动幅值为±0.04 kg/m3，大于体流；在低热通量（2014 W/m2）下，惯性占主导地位，扰动仍然很弱，而高通量（14057 W/m2）产生急剧梯度（~ 0.6 kg/m3）和浮力驱动的不稳定性。边界层对流的时间演化揭示了一个由传导性向以对流为主的传热转变，受浮力-主流耦合和剪切-湍流增强的控制。由于热压缩性、密度梯度增强、湍流扰动反馈和浮力诱导的剪切层失稳，局部热扰动表现出非线性放大。

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引用次数: 0

Evaluation of N,N-dibutyloctanamide as a ligand for supercritical CO₂-mediated plutonium recovery: Solubility, model correlations and extraction studies N，N-二丁烷酰胺作为超临界CO₂介导的钚回收配体的评价：溶解度，模型相关性和萃取研究

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-07-01 Epub Date: 2026-02-11 DOI: 10.1016/j.supflu.2026.106929

A. Divya , K.C. Pitchaiah , C.V.S.Brahmananda Rao

N,N-dialkylamides are increasingly recognized as superior to well-established organophosphorus compounds for extraction/recovery of actinides. This study investigates the development of a green supercritical fluid extraction technique for efficient recovery of plutonium from aqueous waste solutions using N,N-dibutyloctanamide (DBOA). In this context, solubility of DBOA in supercritical carbon dioxide (SCCO₂) is measured to demonstrate its potential in CO₂-assisted green approach for extraction of plutonium. A dynamic flow method was employed to measure the solubilities, over a pressure range of 10 MPa to 20 MPa and temperature ranging from 313 K to 343 K. Solubility was found to be in the order of 10⁻² mol∙mol⁻¹, increasing with pressure while exhibiting retrograde solubility with temperature. Experimental data were correlated using five different models for predictive analysis. Of the models applied, Mendez-Teja equation demonstrated superior prediction with the lowest average deviation and optimal fitting parameters. These results demonstrated that DBOA has adequate solubility in SCCO₂, making it a viable ligand for the recovery of actinides. DBOA was subsequently employed as a ligand for the recovery of plutonium from aqueous waste using an in-house designed glove box. The influence of temperature, pressure and acidity on extraction efficiency was investigated and conditions were optimized. Under optimized conditions, an extraction efficiency of 96 % was achieved. This approach offers a promising route for plutonium recovery from waste matrices with minimum secondary liquid waste generation.

N，N-二烷基酰胺在锕系元素的提取和回收方面越来越被认为优于已建立的有机磷化合物。研究了一种绿色超临界流体萃取技术，利用N，N-二丁烷酰胺（DBOA）从废水中高效回收钚。在这种情况下，测量了DBOA在超临界二氧化碳（SCCO2）中的溶解度，以证明其在二氧化碳辅助绿色方法中提取钚的潜力。在10 MPa ~ 20 MPa的压力范围和313 K ~ 343 K的温度范围内，采用动态流动法测量溶解度。溶解度为10−2 mol∙mol−1，随压力增大而增大，随温度升高呈逆行溶解。实验数据使用五种不同的模型进行预测分析。在所应用的模型中，Mendez-Teja方程具有最低的平均偏差和最佳的拟合参数，具有较好的预测效果。这些结果表明，DBOA在SCCO2中具有足够的溶解度，使其成为锕系元素回收的可行配体。DBOA随后被用作配体，使用内部设计的手套箱从含水废物中回收钚。考察了温度、压力和酸度对提取效率的影响，并对提取条件进行了优化。在优化条件下，提取效率为96% %。该方法为从废基质中回收钚提供了一条有希望的途径，同时减少了二次液体废物的产生。

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引用次数: 0

Numerical study on geometric parameter optimization of wall-cooled hydrothermal combustion reactor 壁冷型水热燃烧反应器几何参数优化的数值研究

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-07-01 Epub Date: 2026-02-12 DOI: 10.1016/j.supflu.2026.106930

Mingjing Fan, Xiaoge Zhang, Yu Zhang, Haoze Wang, Juyuan Mei, Hao Wang, Youjun Lu

A wall-cooled reactor (WCR) for hydrothermal combustion was modeled using the supercritical water diluted flamelet generated manifolds (SCWD-FGM) model for geometric optimization. The effects of four key geometric parameters on reactor performance were systematically analyzed using a one-factor-at-a-time (OFAT) approach. Results indicate that increasing the fuel nozzle inner diameter weakens fuel–oxidizer mixing and reduces reaction intensity while enhancing wall cooling; increasing the fuel nozzle recess depth improves flame stability but raises the oxidizer nozzle inner wall temperature; increasing the cooling water layer thickness has little effect on combustion but strengthens wall protection; and adding additional cooling water injection stages lowers downstream wall temperature while slightly increasing upstream temperature. Based on these insights, a sensitivity-guided coordinate search method was applied to optimize the baseline configuration. The optimized configuration slightly increases the axial distance for 99 % hydrogen conversion by 0.2 mm, but substantially reduces the oxidizer nozzle inner wall temperature by 536 °C and the reactor inner wall temperature by 4 °C. The enlarged geometry increases material consumption by over 70 %, but it reduces the peak temperatures of critical components and broadens the range of feasible structural materials, thereby markedly enhancing operational safety and structural robustness under supercritical conditions.

采用超临界水稀释火焰生成歧管（SCWD-FGM）模型对水热燃烧壁冷反应器（WCR）进行了几何优化建模。采用单因素-一次（OFAT）方法系统分析了四个关键几何参数对反应器性能的影响。结果表明，增大燃料喷嘴内径可减弱燃料-氧化剂混合，降低反应强度，同时增强壁面冷却；增加燃料喷嘴凹槽深度可以改善燃烧稳定性，但会提高氧化剂喷嘴内壁温度；增加冷却水层厚度对燃烧影响不大，但增强了护壁作用；增加额外的冷却水注入级可以降低下游壁温，同时略微提高上游壁温。在此基础上，采用灵敏度导向坐标搜索方法对基线构型进行优化。优化后的结构使99% %氢气转化率的轴向距离略微增加0.2 mm，但使氧化喷嘴内壁温度大幅降低536℃，反应器内壁温度大幅降低4℃。扩大的几何形状使材料消耗增加了70% %以上，但它降低了关键部件的峰值温度，拓宽了可行结构材料的范围，从而显著提高了超临界条件下的操作安全性和结构稳健性。

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引用次数: 0

Engineering Acyclovir-PVP coprecipitated microparticles obtained via different supercritical processes 不同超临界工艺制备的无环韦- pvp共沉淀微粒。

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-02-03 DOI: 10.1016/j.supflu.2026.106922

Maria Chiara Iannaco, Stefania Mottola, Iolanda De Marco

Enhancing the release profile of poorly permeable drugs remains a major challenge in the pharmaceutical field. Coprecipitation with hydrophilic polymers offers a promising strategy to address this issue. The performance of drug delivery systems is largely influenced by particle size, shape, and distribution, critical factors for achieving controlled release and enhanced bioavailability. This study compares two micronization techniques, Supercritical Assisted Atomization (SAA) and Supercritical AntiSolvent (SAS) process, for the coprecipitation of the Acyclovir/Polyvinylpyrrolidone (PVP) system. The effects of polymer-to-drug ratio and total solute concentration were evaluated with respect to particle morphology and size distribution. The thermal behavior, drug loading efficiency, and release profile of the coprecipitates were also examined. Spherical microparticles with a D₅₀ ranging from 0.54 to 0.93 μm and a D₉₀ below 1.7 μm, were successfully produced via SAA, while SAS yielded smaller particles, with D₅₀ between 0.35 and 0.68 μm and D₉₀ lower than 1.06 μm, indicating high sample uniformity. UV–vis analysis revealed high Acyclovir loading efficiencies for SAA microparticles (80–98 %), with slightly lower values for SAS (74–82 %). The in vitro release experiments showed that incorporating PVP markedly improved the drug’s release profile, supporting the effectiveness of supercritical processing methods in enhancing drug dissolution rate and potentially improving the bioavailability of compounds with permeability-limited absorption.

提高低渗透性药物的释放谱仍然是制药领域的主要挑战。与亲水性聚合物共沉淀为解决这一问题提供了一种很有前途的策略。药物传递系统的性能在很大程度上受颗粒大小、形状和分布的影响，这是实现控释和提高生物利用度的关键因素。本研究比较了超临界辅助雾化（SAA）和超临界反溶剂（SAS）两种微粉技术对阿昔洛韦/聚乙烯吡咯烷酮（PVP）体系共沉淀的影响。聚合物-药物比和总溶质浓度对颗粒形态和大小分布的影响进行了评价。研究了共沉淀物的热行为、载药效率和释放特性。SAA法制备出了D50为0.54 ~ 0.93 μm、D90小于1.7 μm的球形微颗粒，而SAS法制备出了D50为0.35 ~ 0.68 μm、D90小于1.06 μm的球形微颗粒，样品均匀性较高。紫外-可见分析显示，SAA微粒的阿昔洛韦负载效率高（80-98 %），SAS微粒的负载效率略低（74-82 %）。体外释放实验表明，加入PVP明显改善了药物的释放谱，支持超临界处理方法在提高药物溶出率方面的有效性，并可能提高具有透性吸收限制的化合物的生物利用度。

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引用次数: 0

Synergistic extraction technologies: A comprehensive review of EASCFE and its applications 协同萃取技术：EASCFE及其应用综述

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-02-02 DOI: 10.1016/j.supflu.2026.106885

Rajanikanta Acharya , Mydavolu Sai Niharika , Divina Christopher, Anitha Anbalagan, Meenakshi Sundaram Muthuraman

EASCFE combines enzymatic hydrolysis with Supercritical Fluid Extraction, offering an innovative and environmentally friendly method for extracting valuable bioactive compounds from complex natural matrices. This comprehensive review explores the principles, mechanisms, and operational parameters governing EASCFE, with a focus on enzyme activity modulation and the role of supercritical CO₂ under varying extraction conditions. Special emphasis is placed on optimizing parameters such as temperature, pH, pressure, enzyme concentration, and the use of co-solvents to improve extraction efficiency. The review also highlights the broad applications of EASCFE, including the recovery of Essential Oils, polyphenols, pigments, lipids, vitamins, and other secondary metabolites. A comparison of traditional and novel extraction methods, such as Ultrasound-Assisted Extraction and Microwave-Assisted Extraction, emphasizes the benefits of EASCFE regarding selectivity, efficiency, and the preservation of compounds. By integrating enzymatic specificity with the unique solvating power of supercritical fluids, EASCFE emerges as a promising green extraction technology with considerable promise in the food, pharmaceutical, and nutraceutical sectors. Future research directions focus on process scale-up, enzyme engineering, and the development of cost-effective industrial applications.

EASCFE将酶解与超临界流体萃取相结合，提供了一种创新和环保的方法，从复杂的天然基质中提取有价值的生物活性化合物。这篇综合综述探讨了EASCFE的原理、机制和操作参数，重点是酶活性调节和超临界CO2在不同提取条件下的作用。特别强调的是优化参数，如温度，pH值，压力，酶浓度，并使用共溶剂，以提高提取效率。综述还强调了EASCFE的广泛应用，包括精油、多酚、色素、脂质、维生素和其他次生代谢物的回收。比较了传统和新型的提取方法，如超声辅助提取和微波辅助提取，强调了EASCFE在选择性、效率和化合物保存方面的优势。通过将酶的特异性与超临界流体的独特溶剂化能力相结合，EASCFE成为一种有前途的绿色萃取技术，在食品、制药和营养保健领域具有相当大的前景。未来的研究方向将集中在工艺放大、酶工程和开发具有成本效益的工业应用上。

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引用次数: 0

Dynamic performance comparison of supercritical CO₂ Brayton cycle layouts using an enhanced dynamic model 基于增强型动态模型的超临界co2 Brayton循环布局动态性能比较

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-01-16 DOI: 10.1016/j.supflu.2026.106896

Tariq Alsawy , Ramy H. Mohammed , Osama Mesalhy , Mohamed Abdelkareem

There is a growing interest in the supercritical CO₂ Brayton cycle (SCO₂BC) as a high-efficiency power generation technology across various energy sectors, including renewable energy. SCO₂BC dynamic modelling is key to grasp its performance, especially under off-design conditions such as fluctuating operating load. Numerous studies that compare the steady-state behavior of different SCO₂BC layouts are present. However, existing literature lacks in-depth analyses of transient responses of different SCO₂BC layouts with accuracy-improved turbomachinery performance-map. This research fills this gap by comparing four layouts: recuperated (RCU), recompression (RCOMP), reheat (RHT), intercool (INC), through dynamic simulations with accuracy-improved turbomachinery models. The transient responses of the key SCO₂BC cycle performance parameters are deeply investigated, offering novel insights into their transient behavior. An additional novelty of this work is the usage of corrected turbomachinery performance maps with improved prediction accuracy for the dynamic comparison. The study reveals that mass flow rate and compressor inlet conditions are most affected by a cooling water temperature disturbance (ColdT), while turbine inlet state is more sensitive to a heater temperature change (HotT). For all the studied layouts, net power responses are primarily driven by mass flow rate and turbine inlet temperature (TIT) for ColdT and HotT disturbances, respectively. Layout configurations (number and arrangement of turbomachines) influence transient response sensitivity. RCU and RHT layouts exhibit larger net power fluctuations for ColdT, while RCU and INC layouts show larger responses for HotT. The RCOMP is generally the most stable layout, while RHT and INC demonstrate conditional stability depending on the disturbance.

超临界二氧化碳布雷顿循环（SCO2BC）作为一种高效发电技术，在包括可再生能源在内的各个能源领域受到越来越多的关注。SCO2BC动态建模是掌握其性能的关键，特别是在非设计工况下，如运行负荷波动。目前有许多研究比较了不同SCO2BC布局的稳态行为。然而，现有文献缺乏利用精度改进的涡轮机械性能图对不同SCO2BC布局的瞬态响应进行深入分析。本研究通过采用改进精度的涡轮机械模型进行动态仿真，比较了四种布局：回热（RCU）、再压缩（RCOMP）、再热（RHT）、中冷（INC），填补了这一空白。深入研究了关键SCO2BC循环性能参数的瞬态响应，为其瞬态行为提供了新的见解。这项工作的另一个新颖之处是使用了校正的涡轮机械性能图，提高了动态比较的预测精度。研究表明，质量流量和压气机进口状态受冷却水温度扰动（ColdT）的影响最大，而涡轮进口状态受加热器温度变化（HotT）的影响更为敏感。对于所有研究的布局，净功率响应主要是由质量流量和涡轮进口温度（TIT）分别对ColdT和HotT扰动驱动。布局配置（涡轮的数量和排列）影响瞬态响应灵敏度。RCU和RHT布局对ColdT表现出较大的净功率波动，而RCU和INC布局对HotT表现出较大的响应。RCOMP通常是最稳定的布局，而RHT和INC则根据干扰表现出条件稳定性。

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引用次数: 0

Evaluation of the PρT-SAFT, PC-SAFT, I-PC-SAFT, PρT-PC-SAFT, SRK, PR, and PT equations of state for predicting thermodynamic properties of furfural, its derivatives, and their mixtures 预测糠醛及其衍生物及其混合物热力学性质的PρT-SAFT、PC-SAFT、I-PC-SAFT、PρT-PC-SAFT、SRK、PR和PT状态方程的评价

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-02-06 DOI: 10.1016/j.supflu.2026.106926

Arash Pakravesh , Amir H. Mohammadi , Dominique Richon

Thermodynamic properties of furfural (FUR), its derivatives, and their mixtures were modeled using cubic and SAFT-type equations of state (EoSs) to assess their relative accuracy for process design and optimization. To this end, PρT-SAFT EoS parameters for FUR, furfuryl alcohol, tetrahydrofurfuryl alcohol, furfuryl acetate, furfuryl propionate, furfuryl butyrate, and 5-methylfurfural were determined. Subsequently, the thermodynamic properties of pure FUR and its derivatives, including volumetric properties, caloric properties, and VLE, were evaluated using seven EoSs (SRK, PR, PT, PρT-SAFT, PC-SAFT, I-PC-SAFT, and PρT-PC-SAFT), based on the availability of experimental data and adjustable parameters. For PC-SAFT, multiple published parameter sets were compared where applicable. In summary, for pure compounds, SAFT-based EoSs consistently outperformed cubic EoSs across all properties examined. Among all models, PρT-SAFT provided the highest overall accuracy, yielding the lowest deviations for density, heat capacity, speed of sound, and VLE predictions. Based on these results, only PC-SAFT, PρT-PC-SAFT, and PρT-SAFT were applied to model seven binary mixtures containing FUR and its derivatives, for which density, sound velocity, VLE, and LLE were predicted. PρT-SAFT showed superior performance for all mixture properties considered and consistently improved agreement with experimental data compared to PC-SAFT and PρT-PC-SAFT. Quantitatively, the PρT-SAFT and PρT-PC-SAFT EoSs achieved a total average absolute deviation (AAD) of 1.8 % and 2.3 % for the studied systems, compared to 5.3 % for PC-SAFT parameterized using VLE data. These results demonstrate that, for SAFT-type EoSs applied to FUR-based systems, the parameterization strategy, particularly the use of

P ρ T

data, has a greater impact on predictive accuracy than the specific theoretical formulation of the EoS.

利用立方态方程和saft型态方程对糠醛（FUR）及其衍生物及其混合物的热力学性质进行了建模，以评估其相对精度，为工艺设计和优化提供依据。为此，测定了FUR、糠醇、四氢糠醇、醋酸糠醇、丙酸糠醇、丁酸糠醇和5-甲基糠醛的ρ t - saft EoS参数。随后，基于实验数据的可用性和可调参数，使用7种eos （SRK、PR、PT、PρT-SAFT、PC-SAFT、I-PC-SAFT和PρT-PC-SAFT）评估纯FUR及其衍生物的热力学性质，包括体积性质、热性质和VLE。对于PC-SAFT，在适用的情况下比较多个公布的参数集。综上所述，对于纯化合物，基于saft的EoSs在所有性能测试中都优于立方EoSs。在所有模型中，prρ t - saft提供了最高的整体精度，在密度、热容、声速和VLE预测方面偏差最小。在此基础上，仅应用PC-SAFT、PρT-PC-SAFT和PρT-SAFT对含FUR及其衍生物的七种二元混合物进行了建模，并对其密度、声速、VLE和LLE进行了预测。与PC-SAFT和PρT-PC-SAFT相比，PρT-PC-SAFT在考虑的所有混合物性能方面都表现出优越的性能，并且与实验数据的一致性不断提高。定量地说，所研究系统的PρT-SAFT和PρT-PC-SAFT eos的总平均绝对偏差（AAD）为1.8 %和2.3 %，而使用VLE数据参数化的PC-SAFT的AAD为5.3 %。这些结果表明，对于应用于基于fur的系统的saft型EoS，参数化策略，特别是使用PρT数据，对预测精度的影响比EoS的特定理论公式更大。

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引用次数: 0

3-aminopropyltriethoxysilane (APTES) coating of glass surface using supercritical CO2: A solvent-free approach 超临界CO2玻璃表面3-氨基丙基三乙氧基硅烷（APTES）涂层：无溶剂方法

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-01-09 DOI: 10.1016/j.supflu.2026.106887

Asifa Awan , Peter Fojan , Rudi P. Nielsen , Morten E. Simonsen

A sustainable alternative to conventional silanization techniques has been investigated with supercritical carbon dioxide (scCO₂) as a solvent for 3-aminopropyltriethoxysilane (APTES) deposition on glass surfaces. APTES deposition behavior was systematically evaluated under varying operational parameters, including pressure (90 and 150 bar), temperature (100–140°C), and reaction time (3 and 5 hr). FTIR spectroscopy, atomic force microscopy (AFM), and drop shape analysis (DSA) were employed to assess the chemical modifications, surface morphology, and wettability of the coated glass. Results demonstrated that temperature and pressure significantly govern the coating process, with increased pressure positively correlating with APTES deposition while elevated temperatures (100°C to 140°C) reduced deposition efficiency. AFM analysis revealed that surface roughness (Ra) increased progressively with higher pressure and longer reaction times, ranging from approximately 0.7 nm for lightly treated surfaces to over 10 nm for heavily coated samples. This confirmed the transition from uniform coatings to agglomerated surface structures at higher operating conditions. Surface energy determination demonstrated that the dispersive component of the surface energy consistently dominated, while the polar component varied with temperature, indicating a temperature-dependent modification of the surface functionalities. The density of scCO₂ emerged as a critical factor affecting surface deposition, with maximum deposition occurring within the 281–333 kg/m³ density range. Notably, complete silanization reactions and homogeneous surfaces were achieved primarily at lower scCO₂ densities.

研究了以超临界二氧化碳（scCO2）为溶剂在玻璃表面沉积3-氨基丙基三乙氧基硅烷（APTES）的可持续替代传统硅烷化技术。在不同的操作参数下，包括压力（90和150bar）、温度（100-140°C）和反应时间（3和5小时），系统地评估了APTES沉积行为。采用FTIR光谱、原子力显微镜（AFM）和液滴形状分析（DSA）来评估涂层玻璃的化学修饰、表面形貌和润湿性。结果表明，温度和压力对涂层过程有显著影响，压力升高与APTES沉积呈正相关，而温度升高（100°C至140°C）会降低沉积效率。AFM分析显示，表面粗糙度（Ra）随着压力的增加和反应时间的延长而逐渐增加，从轻度处理的表面约0.7nm到重度涂层样品的超过10nm。这证实了在更高的操作条件下，从均匀涂层到凝聚表面结构的转变。表面能测定表明，表面能的色散成分一直占主导地位，而极性成分随温度变化，表明表面官能的变化依赖于温度。scCO2密度是影响地表沉积的关键因素，最大沉积发生在281-333kg/m3密度范围内。值得注意的是，完全硅烷化反应和均匀表面主要是在较低的scCO2密度下实现的。

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引用次数: 0

High-pressure extraction of marigold (Calendula officinalis); Evaluation of chemical composition, pharmacological and antitumor potential 高压提取万寿菊（Calendula officinalis）评价其化学成分、药理及抗肿瘤潜能

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-01-17 DOI: 10.1016/j.supflu.2026.106898

Mirjana Sulejmanović , Senka Vidović , Igor Jerković , Nataša Milić , Aleksandra Popović , Jelena Jeremić , Vanja Travičić , Stela Jokić , Krunoslav Aladić , Aleksandra Gavarić

The isolation of bioactive compounds from plants has gained significant attention due to their potential in developing novel health-promoting products. Among these, marigold (Calendula officinalis) is recognized for its antioxidant, hepatoprotective, and wound-healing properties. This study examined five marigold plant parts–petals (MP), calyxes (MC), calyxes with petals (MCP), stems (MS), and stems with calyxes and petals (MSCP)–extracted using supercritical carbon dioxide (scCO₂), an advanced technique that avoids toxic solvents and reduces extraction time compared to conventional methods. GC–MS analysis of the scCO₂ extracts revealed that sesquiterpenes were the predominant constituents, including δ-cadinene (19.13–26.96 %), γ-cadinene (9.62–12.92 %), t-muurolol (2.08–10.07 %), α-cadinol (1.42–5.81 %), and ledene (1.24–8.87 %). In addition, monoterpenes such as thymol (1.85–2.87 %), camphor (1.77–2.07 %), β-thujone (0.93–1.13 %), and carvacrol (0.58–1.25 %), as well as the alkane nonadecane (0.50–23.17 %), were also identified. The in vitro antitumor potential of MP, MC, and MS plant parts was evaluated in H4IIE hepatoma cells. Cell viability, morphological analysis, and colony formation assays demonstrated cytotoxic activity, with marigold calyxes showing the most pronounced effect. In addition, hepatoprotective properties were confirmed, further supporting the therapeutic relevance of marigold extracts. These findings suggest that sc-CO₂ extracts of marigold hold promise as potential antitumor agents. However, further preclinical and clinical studies are required to assess their safety, efficacy, and applicability in human therapy.

从植物中分离生物活性化合物因其在开发新型健康促进产品方面的潜力而受到广泛关注。其中，金盏花（Calendula officinalis）被认为具有抗氧化、保护肝脏和伤口愈合的特性。与传统的提取方法相比，超临界二氧化碳（scCO₂）技术避免了有毒溶剂，缩短了提取时间，研究了金盏花植物的5个部分——花瓣（MP）、花萼（MC）、花萼带花瓣（MCP）、茎（MS）、茎带花萼和花瓣（MSCP）。GC-MS分析表明，scCO₂提取物的主要成分为倍半萜类，包括δ-cadinene（19.13 ~ 26.96 %）、γ-cadinene（9.62 ~ 12.92 %）、t-muurolol（2.08 ~ 10.07 %）、α-cadinol（1.42 ~ 5.81 %）和ledene（1.24 ~ 8.87 %）。此外，还鉴定出百里香酚（1.85 ~ 2.87 %）、樟脑（1.77 ~ 2.07 %）、β-thujone（0.93 ~ 1.13 %）、香芹醇（0.58 ~ 1.25 %）等单萜类化合物，以及烷烃壬烷（0.50 ~ 23.17 %）。在H4IIE肝癌细胞中评价了MP、MC和MS植物部位的体外抗肿瘤作用。细胞活力、形态分析和集落形成分析显示细胞毒性活性，其中万寿菊花萼表现出最明显的效果。此外，还证实了万寿菊提取物的肝保护作用，进一步支持了万寿菊提取物的治疗相关性。这些发现表明，金盏花的sc-CO₂提取物有望成为潜在的抗肿瘤药物。然而，需要进一步的临床前和临床研究来评估它们在人类治疗中的安全性、有效性和适用性。

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引用次数: 0

Green preparation of polyvinyl chloride/epoxy resin blend foams using supercritical CO2 超临界CO2绿色制备聚氯乙烯/环氧树脂共混泡沫

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.supflu.2026.106916

Xuelin Zhang, Xiulu Gao, Qiyuan He, Haonan Chen, Yichong Chen, Ling Zhao, Dongdong Hu

This study utilized the environmentally friendly plasticizer epoxidized soybean oil as a phthalate alternative and implemented a plasticization-curing-reinforcement strategy via epoxy resin to systematically examine the processing characteristics and supercritical carbon dioxide foaming behavior of a polyvinyl chloride/epoxy resin (PVC/EP) blend system. The incorporation of EP significantly improves the flowability and accelerates the fusion (gelation) process of PVC. The appropriate EP content reduces the complex viscosity of PVC/EP blends and enhances the processability due to the plasticization effect. After EP curing, the tensile properties of PVC/EP blends are enhanced. When the EP content reaches 20 %, the elongation at break of cured PVC/EP blend increases from 11 % to 218 %, while the tensile strength remains comparable to that of pure PVC, collectively resulting in an effective toughening effect. The plasticization effect of EP improves the foaming behavior of PVC/EP blends. When the EP content is 20 %, the cell morphology of PVC/EP blend foam is optimized and the expansion ratio is significantly increased from 5 times to 15 times. Cured PVC/EP blend foam exhibits excellent compressive properties and thermal stability. Compared to pure PVC foam, the compressive modulus, compressive strength, and initial thermal decomposition temperature increased by 340.2 %, 47.8 %, and 36 °C, respectively. This work presents a feasible strategy for producing environmentally friendly, high-performance PVC foams through EP blending and CO₂ foaming.

本研究采用环保型增塑剂环氧大豆油作为邻苯二甲酸酯的替代品，并通过环氧树脂实施增塑化-固化-增强策略，系统地研究了聚氯乙烯/环氧树脂（PVC/EP）共混体系的加工特性和超临界二氧化碳发泡行为。EP的掺入显著改善了PVC的流动性，加速了PVC的融合（凝胶）过程。适当的EP含量降低了PVC/EP共混物的复合粘度，并由于塑化作用提高了加工性能。EP固化后，PVC/EP共混物的拉伸性能得到提高。当EP含量达到20 %时，固化后的PVC/EP共混物的断裂伸长率由11 %提高到218 %，而拉伸强度仍与纯PVC相当，整体增韧效果良好。EP的增塑作用改善了PVC/EP共混物的发泡性能。当EP含量为20 %时，优化了PVC/EP共混泡沫的细胞形态，膨胀率从5倍显著提高到15倍。固化PVC/EP共混泡沫具有优异的抗压性能和热稳定性。与纯PVC泡沫相比，抗压模量、抗压强度和初始热分解温度分别提高了340.2 %、47.8 %和36℃。本研究提出了一种通过EP共混和CO2发泡生产环保型高性能PVC泡沫的可行策略。

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引用次数: 0