Abul Hasnat Md Shamim , Md Abdul Mojid Mondol , Miraj Hossain , Tanvir Islam Shovo , Minhaz Uddin , Mohammad Nur-e-Alam , Iftekhar Alam , Hattan A. Alharbi , A.F.M. Motiur Rahman
{"title":"从内生真菌黑曲霉中分离出具有不寻常 12 元残基酸内酯环的新型抗菌青霉烯内酯 G","authors":"Abul Hasnat Md Shamim , Md Abdul Mojid Mondol , Miraj Hossain , Tanvir Islam Shovo , Minhaz Uddin , Mohammad Nur-e-Alam , Iftekhar Alam , Hattan A. Alharbi , A.F.M. Motiur Rahman","doi":"10.1016/j.phytol.2024.06.003","DOIUrl":null,"url":null,"abstract":"<div><p>Current antibiotics are increasingly losing their effectiveness against multidrug-resistant pathogenic bacteria, necessitating the search for new antibiotics. Endophytic fungi are widely recognized as valuable sources of structurally novel secondary metabolites with diverse biological activities. In this study, an endophytic fungus, designated KRL01, was isolated from a leaf of <em>Capparis carandas</em>. The strain was identified as <em>Aspergillus giganteus</em> through analysis of its internal transcribed spacer (ITS) rDNA sequence. Subsequently, the fungus was cultured in a rice medium and extracted using ethyl acetate. A novel metabolite, named penicimenolide G (<strong>1</strong>), was isolated from the extract using chromatography. Compound <strong>1</strong> demonstrated potent antibacterial activity against both Gram-positive and Gram-negative bacterial strains, including those resistant to the standard antibiotic amoxicillin.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"62 ","pages":"Pages 18-23"},"PeriodicalIF":1.3000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New antibacterial penicimenolide G with unusual 12-membered resorcylic acid lactone ring isolated from endophytic fungus Aspergillus giganteus\",\"authors\":\"Abul Hasnat Md Shamim , Md Abdul Mojid Mondol , Miraj Hossain , Tanvir Islam Shovo , Minhaz Uddin , Mohammad Nur-e-Alam , Iftekhar Alam , Hattan A. Alharbi , A.F.M. Motiur Rahman\",\"doi\":\"10.1016/j.phytol.2024.06.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Current antibiotics are increasingly losing their effectiveness against multidrug-resistant pathogenic bacteria, necessitating the search for new antibiotics. Endophytic fungi are widely recognized as valuable sources of structurally novel secondary metabolites with diverse biological activities. In this study, an endophytic fungus, designated KRL01, was isolated from a leaf of <em>Capparis carandas</em>. The strain was identified as <em>Aspergillus giganteus</em> through analysis of its internal transcribed spacer (ITS) rDNA sequence. Subsequently, the fungus was cultured in a rice medium and extracted using ethyl acetate. A novel metabolite, named penicimenolide G (<strong>1</strong>), was isolated from the extract using chromatography. Compound <strong>1</strong> demonstrated potent antibacterial activity against both Gram-positive and Gram-negative bacterial strains, including those resistant to the standard antibiotic amoxicillin.</p></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"62 \",\"pages\":\"Pages 18-23\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024000946\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024000946","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
New antibacterial penicimenolide G with unusual 12-membered resorcylic acid lactone ring isolated from endophytic fungus Aspergillus giganteus
Current antibiotics are increasingly losing their effectiveness against multidrug-resistant pathogenic bacteria, necessitating the search for new antibiotics. Endophytic fungi are widely recognized as valuable sources of structurally novel secondary metabolites with diverse biological activities. In this study, an endophytic fungus, designated KRL01, was isolated from a leaf of Capparis carandas. The strain was identified as Aspergillus giganteus through analysis of its internal transcribed spacer (ITS) rDNA sequence. Subsequently, the fungus was cultured in a rice medium and extracted using ethyl acetate. A novel metabolite, named penicimenolide G (1), was isolated from the extract using chromatography. Compound 1 demonstrated potent antibacterial activity against both Gram-positive and Gram-negative bacterial strains, including those resistant to the standard antibiotic amoxicillin.
期刊介绍:
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.