从内生真菌黑曲霉中分离出具有不寻常 12 元残基酸内酯环的新型抗菌青霉烯内酯 G

IF 1.3 4区 生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2024-06-24 DOI:10.1016/j.phytol.2024.06.003
Abul Hasnat Md Shamim , Md Abdul Mojid Mondol , Miraj Hossain , Tanvir Islam Shovo , Minhaz Uddin , Mohammad Nur-e-Alam , Iftekhar Alam , Hattan A. Alharbi , A.F.M. Motiur Rahman
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引用次数: 0

摘要

目前的抗生素对具有多重耐药性的病原菌越来越失去效力,因此有必要寻找新的抗生素。内生真菌被广泛认为是具有多种生物活性的结构新颖的次级代谢产物的宝贵来源。本研究从 Capparis carandas 的叶片中分离出一种内生真菌,命名为 KRL01。通过分析其内部转录间隔(ITS)rDNA 序列,确定该菌株为巨曲霉。随后,在水稻培养基中培养该真菌,并使用乙酸乙酯进行提取。利用色谱法从提取物中分离出一种新型代谢物,命名为青霉内酯 G(1)。化合物 1 对革兰氏阳性和革兰氏阴性细菌菌株都有很强的抗菌活性,包括对标准抗生素阿莫西林耐药的菌株。
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New antibacterial penicimenolide G with unusual 12-membered resorcylic acid lactone ring isolated from endophytic fungus Aspergillus giganteus

Current antibiotics are increasingly losing their effectiveness against multidrug-resistant pathogenic bacteria, necessitating the search for new antibiotics. Endophytic fungi are widely recognized as valuable sources of structurally novel secondary metabolites with diverse biological activities. In this study, an endophytic fungus, designated KRL01, was isolated from a leaf of Capparis carandas. The strain was identified as Aspergillus giganteus through analysis of its internal transcribed spacer (ITS) rDNA sequence. Subsequently, the fungus was cultured in a rice medium and extracted using ethyl acetate. A novel metabolite, named penicimenolide G (1), was isolated from the extract using chromatography. Compound 1 demonstrated potent antibacterial activity against both Gram-positive and Gram-negative bacterial strains, including those resistant to the standard antibiotic amoxicillin.

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来源期刊
Phytochemistry Letters
Phytochemistry Letters 生物-生化与分子生物学
CiteScore
3.00
自引率
11.80%
发文量
190
审稿时长
34 days
期刊介绍: Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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