Wenbo Wang , Pei Wang , Qinlin Li , Wufei Dai, Bingcheng Yi, Zhen Gao, Wei Liu, Xiansong Wang
{"title":"用于高级肌腱修复的压电增强复合膜模拟肌腱电微环境","authors":"Wenbo Wang , Pei Wang , Qinlin Li , Wufei Dai, Bingcheng Yi, Zhen Gao, Wei Liu, Xiansong Wang","doi":"10.1016/j.nantod.2024.102381","DOIUrl":null,"url":null,"abstract":"<div><p>Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of the collagen matrix and are typically accompanied by pronounced inflammatory responses and perturbations in the tendon's intrinsic electrical microenvironment. Despite advancements in bridging tendon injuries, few strategies currently target the restoration of the tendon's native electrical microenvironment to facilitate repair. Herein, we fabricated electrospun fibers composed of polycaprolactone (PCL) loaded with dopamine (PDA) modified piezoelectric tetragonal-SrTiO<sub>3</sub> (T-SrTiO<sub>3</sub>) (T-SrTiO<sub>3</sub>@PCL) for overcoming this problem. The application of PCL based electrospun fibers favours the bridging of tendon injuries by reconstructing the collagen matrix, while the incorporation of piezoelectric T-SrTiO<sub>3</sub> simulates the endogenous electrical microenvironment of tendon tissue, with the PDA enhancing the combination between T-SrTiO<sub>3</sub> and PCL and thereby further increase piezoelectricity. The therapeutic potential of T-SrTiO<sub>3</sub>@PCL fibers in tendon repair was evidenced by their ability to modulate the inflammatory response, reduce angiogenesis, and upregulate tendon-specific gene expression, as demonstrated in both <em>in vivo</em> and <em>in vitro</em> experiments. These findings underscore the multifunctional electrospun fibers as a novel strategy for tendon repair, emphasizing the critical structure-function relationship in tendon tissue and recreating a conducive electrical microenvironment for regeneration.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224002378/pdfft?md5=14fba532ffc0ea2ab6e2f15719f752b6&pid=1-s2.0-S1748013224002378-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Piezoelectrically-enhanced composite membranes mimicking the tendinous electrical microenvironment for advanced tendon repair\",\"authors\":\"Wenbo Wang , Pei Wang , Qinlin Li , Wufei Dai, Bingcheng Yi, Zhen Gao, Wei Liu, Xiansong Wang\",\"doi\":\"10.1016/j.nantod.2024.102381\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of the collagen matrix and are typically accompanied by pronounced inflammatory responses and perturbations in the tendon's intrinsic electrical microenvironment. Despite advancements in bridging tendon injuries, few strategies currently target the restoration of the tendon's native electrical microenvironment to facilitate repair. Herein, we fabricated electrospun fibers composed of polycaprolactone (PCL) loaded with dopamine (PDA) modified piezoelectric tetragonal-SrTiO<sub>3</sub> (T-SrTiO<sub>3</sub>) (T-SrTiO<sub>3</sub>@PCL) for overcoming this problem. The application of PCL based electrospun fibers favours the bridging of tendon injuries by reconstructing the collagen matrix, while the incorporation of piezoelectric T-SrTiO<sub>3</sub> simulates the endogenous electrical microenvironment of tendon tissue, with the PDA enhancing the combination between T-SrTiO<sub>3</sub> and PCL and thereby further increase piezoelectricity. The therapeutic potential of T-SrTiO<sub>3</sub>@PCL fibers in tendon repair was evidenced by their ability to modulate the inflammatory response, reduce angiogenesis, and upregulate tendon-specific gene expression, as demonstrated in both <em>in vivo</em> and <em>in vitro</em> experiments. These findings underscore the multifunctional electrospun fibers as a novel strategy for tendon repair, emphasizing the critical structure-function relationship in tendon tissue and recreating a conducive electrical microenvironment for regeneration.</p></div>\",\"PeriodicalId\":395,\"journal\":{\"name\":\"Nano Today\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.2000,\"publicationDate\":\"2024-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1748013224002378/pdfft?md5=14fba532ffc0ea2ab6e2f15719f752b6&pid=1-s2.0-S1748013224002378-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Today\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1748013224002378\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224002378","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Piezoelectrically-enhanced composite membranes mimicking the tendinous electrical microenvironment for advanced tendon repair
Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of the collagen matrix and are typically accompanied by pronounced inflammatory responses and perturbations in the tendon's intrinsic electrical microenvironment. Despite advancements in bridging tendon injuries, few strategies currently target the restoration of the tendon's native electrical microenvironment to facilitate repair. Herein, we fabricated electrospun fibers composed of polycaprolactone (PCL) loaded with dopamine (PDA) modified piezoelectric tetragonal-SrTiO3 (T-SrTiO3) (T-SrTiO3@PCL) for overcoming this problem. The application of PCL based electrospun fibers favours the bridging of tendon injuries by reconstructing the collagen matrix, while the incorporation of piezoelectric T-SrTiO3 simulates the endogenous electrical microenvironment of tendon tissue, with the PDA enhancing the combination between T-SrTiO3 and PCL and thereby further increase piezoelectricity. The therapeutic potential of T-SrTiO3@PCL fibers in tendon repair was evidenced by their ability to modulate the inflammatory response, reduce angiogenesis, and upregulate tendon-specific gene expression, as demonstrated in both in vivo and in vitro experiments. These findings underscore the multifunctional electrospun fibers as a novel strategy for tendon repair, emphasizing the critical structure-function relationship in tendon tissue and recreating a conducive electrical microenvironment for regeneration.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.