将脱落细胞学中的微核检测作为口腔癌发生过程中遗传损伤的临床生物标志物的最新进展:系统回顾与元分析》。

IF 6.4 2区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2024-07-01 DOI:10.1016/j.mrrev.2024.108508
Vito Carlo Alberto Caponio , Fábio França-Vieira e Silva , Francesco Popolo , Sara Giugliano , Francesca Spizzirri , Alejandro I. Lorenzo-Pouso , María Elena Padín-Iruegas , Khrystyna Zhurakivska , Lorenzo Lo Muzio , Rosa María López-Pintor
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引用次数: 0

摘要

口腔鳞状细胞癌(OSCC)是最常见的口腔恶性肿瘤,发病前往往先出现口腔潜在恶性疾病(OPMD)。目前,尚无临床生物标志物可预测恶性程度,因此有必要对口腔潜在恶性疾病进行随访。吸烟和饮酒等习惯和环境因素会影响 OSCC 的发病。微核(MNs)的形成与正常粘膜和 OSCC 的进展有关。脱落细胞学等非侵入性诊断测试提供了无痛和定期监测的选择。本研究评估了烟草、酒精和杀虫剂暴露对脱落细胞学收集的口腔黏膜细胞中MNs发生的影响,评估了它们作为非侵入性生物标记物预测和监测高危患者OSCC发展的潜力。尽管这项荟萃分析的结果表明,从对照组到口腔黏膜病变患者再到 OSCC,存在一个逐步上升的过程,但由于个体内和个体间的异质性,以及 MNs 定量方法的差异性,这些发现在临床实践中的应用受到了限制。造成这种异质性的因素有很多,包括人口统计学变量、不同实验室的方法学变量、染色技术、样本采集地点和患者特征。讨论了所有这些问题,以便为今后的研究提供进一步的见解并提高标准化程度。
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State of art of micronuclei assay in exfoliative cytology as a clinical biomarker of genetic damage in oral carcinogenesis: A systematic review and meta-analysis

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy, often preceded by oral potentially malignant disorders (OPMDs). Currently, no clinical biomarker exists to predict malignancy, necessitating OPMD follow-up. Habits and environmental factors, such as smoking, and alcohol consumption, influence OSCC onset. Increased micronuclei (MNs) formation has been observed in the development of OSCC. Non-invasive diagnostic tests like exfoliative cytology offer painless and regular monitoring options. This study evaluates the impact of tobacco, alcohol, and pesticide exposure on MNs occurrence in exfoliative cytology-collected oral mucosal cells, assessing their potential as non-invasive biomarker for OSCC development prediction and monitoring in high-risk patients. Despite results from this meta-analysis supporting the existence of a stepwise increase from controls to patients with OPMD to OSCC, the translation of these findings into clinical practice is limited due to intra- and inter-individual heterogeneity, as well as methodological variability in MNs quantification. Various factors contribute to this heterogeneity, including demographic variables, methodological variability of different laboratories, staining techniques, sample collection location, and patient characteristics. All these points were discussed to provide further insights and improve standardization for future studies.

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来源期刊
CiteScore
12.20
自引率
1.90%
发文量
22
审稿时长
15.7 weeks
期刊介绍: The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.
期刊最新文献
State of art of micronuclei assay in exfoliative cytology as a clinical biomarker of genetic damage in oral carcinogenesis: A systematic review and meta-analysis A critical review of the impact of candidate copy number variants on autism spectrum disorder Use of micronucleus cytome assays with buccal cells for the detection of genotoxic effects: A systematic review and meta-analysis of occupational exposures to metals Genome-scale mutational signature analysis in fixed archived tissues Mechanistic insights into cisplatin response in breast tumors: Molecular determinants and drug/nanotechnology-based therapeutic opportunities
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