白尾狨(Callithrix jacchus)饮用乙醇的探索性研究。

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Alcohol Pub Date : 2024-07-04 DOI:10.1016/j.alcohol.2024.07.001
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引用次数: 0

摘要

白尾狨猴是一种小型非人灵长类动物,作为一种模型生物,尤其是神经科学研究的模型生物,它正迅速受到人们的欢迎。迄今为止,酒精研究领域利用狨猴开展的工作还很少。为了将狨猴作为酒精实验的研究模型,我们开展了一系列探索性研究,以确定乙醇饮酒行为的特征。研究人员建立了一个自愿饮酒范例,让普通狨猴饮用药理相关量的乙醇。为了便于饮用乙醇,乙醇与棉花糖味溶液(以下称棉花糖汁)混合在一起,以掩盖乙醇的假定不良味道。使用棉花糖汁调味溶液,狨猴很容易在 10 分钟的狂饮过程中摄入高达 1 克/千克的乙醇,或在 4 小时的饮酒过程中摄入高达 5 克/千克的乙醇。在 30 分钟的饮酒过程中,每公斤摄入 1.0-1.5 克乙醇会导致血液中的乙醇浓度达到 49-73 毫克/分升,预计该浓度与药理学相关。在稳定摄入棉花糖汁乙醇的动物中,逐渐降低棉花糖汁调味剂的浓度可显著减少乙醇摄入量。最后,当让狨猴在棉花糖汁中的乙醇和单独的棉花糖汁之间进行选择时,狨猴对不含乙醇的棉花糖汁溶液表现出强烈的偏好。根据这些研究得出的结论是,如果用棉花糖汁等甜味溶液掩盖乙醇的味道,狨猴会自愿摄入乙醇。这些研究首次报道了白尾狨对酒精的消费和偏好。
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Exploratory studies of ethanol drinking in the white-tufted marmoset (Callithrix jacchus)

The white-tufted marmoset is a small, nonhuman primate that is rapidly gaining popularity as a model organism, especially for neuroscience research. To date, little work in the alcohol research field has utilized the marmoset. As a step toward establishing the marmoset as a research model for alcohol experimentation, a series of exploratory studies were undertaken to characterize ethanol drinking behavior. A voluntary drinking paradigm was established whereby the common marmoset would consume pharmacologically relevant amounts of ethanol. To facilitate ethanol consumption, ethanol was mixed with a marshmallow flavored solution (hereafter called marshmallow juice) to mask the presumed adverse taste of ethanol. Using marshmallow juice flavored solutions, marmosets readily consumed ethanol up to 1 g/kg during 10 min binge-like drinking sessions or up to 5 g/kg during ∼4 h drinking sessions. Consumption of 1.0–1.5 g/kg during a 30 min session resulted in blood ethanol concentrations of 49–73 mg/dl, which are predicted to be pharmacologically relevant. In animals that were stably consuming ethanol in marshmallow juice, gradually reducing the concentration of the marshmallow juice flavoring resulted in markedly reduced ethanol consumption. Lastly, when offered a choice between ethanol in marshmallow juice and marshmallow juice alone, marmosets displayed a very strong preference for the marshmallow juice solution without ethanol. From these studies, it is concluded that marmosets will voluntarily consume ethanol if the taste is masked with a sweet solution such as marshmallow juice. These studies represent the first report of alcohol consumption and preference in the white-tufted marmoset.

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来源期刊
Alcohol
Alcohol 医学-毒理学
CiteScore
4.60
自引率
4.30%
发文量
74
审稿时长
15.6 weeks
期刊介绍: Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.
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