使用天然聚合物的双层镀膜隐形眼镜的药物释放和物理特性

IF 2.8 4区 工程技术 Q2 POLYMER SCIENCE Macromolecular Research Pub Date : 2024-07-04 DOI:10.1007/s13233-024-00289-z
Hye Ji Kim, Hyun Mee Lee
{"title":"使用天然聚合物的双层镀膜隐形眼镜的药物释放和物理特性","authors":"Hye Ji Kim,&nbsp;Hyun Mee Lee","doi":"10.1007/s13233-024-00289-z","DOIUrl":null,"url":null,"abstract":"<div><p>This study aims to develop contact lenses with improved drug-release duration time by layer-by-layer (LBL) coating with natural polymers on contact lenses containing the drug gatifloxacin. LBL coating was performed in single and double layers on contact lenses containing gatifloxaxin using natural polymers carrageenan and polylysine. The performance of contact lenses was evaluated based on various physical properties and antibacterial properties. As a result, contact lenses containing gatifloxacin have reduced physical properties compared to lenses without gatifloxacin. As the concentration of gatifloxacin increased, oxygen permeability and wettability decreased, and antibacterial properties increased. LBL coating improved the wettability and antibacterial properties of contact lenses and increased the drug-release duration. Double-layers coated lenses increased the duration of drug release more than single-coated lenses.</p><h3>Graphic Abstract</h3><p>Double layer-coating with poly-L-lysine and carrageenan on contact lenses</p>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 10","pages":"981 - 988"},"PeriodicalIF":2.8000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13233-024-00289-z.pdf","citationCount":"0","resultStr":"{\"title\":\"Drug release and physical properties of double layers coated contact lenses using natural polymers\",\"authors\":\"Hye Ji Kim,&nbsp;Hyun Mee Lee\",\"doi\":\"10.1007/s13233-024-00289-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study aims to develop contact lenses with improved drug-release duration time by layer-by-layer (LBL) coating with natural polymers on contact lenses containing the drug gatifloxacin. LBL coating was performed in single and double layers on contact lenses containing gatifloxaxin using natural polymers carrageenan and polylysine. The performance of contact lenses was evaluated based on various physical properties and antibacterial properties. As a result, contact lenses containing gatifloxacin have reduced physical properties compared to lenses without gatifloxacin. As the concentration of gatifloxacin increased, oxygen permeability and wettability decreased, and antibacterial properties increased. LBL coating improved the wettability and antibacterial properties of contact lenses and increased the drug-release duration. Double-layers coated lenses increased the duration of drug release more than single-coated lenses.</p><h3>Graphic Abstract</h3><p>Double layer-coating with poly-L-lysine and carrageenan on contact lenses</p>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":688,\"journal\":{\"name\":\"Macromolecular Research\",\"volume\":\"32 10\",\"pages\":\"981 - 988\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13233-024-00289-z.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecular Research\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13233-024-00289-z\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Research","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13233-024-00289-z","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

摘要

本研究旨在通过在含有药物加替沙星的隐形眼镜上使用天然聚合物进行逐层涂布(LBL),开发出药物释放持续时间更长的隐形眼镜。使用天然聚合物卡拉胶和聚赖氨酸对含有加替沙星的隐形眼镜进行了单层和双层 LBL 涂层。根据各种物理特性和抗菌特性对隐形眼镜的性能进行了评估。结果显示,与不含加替沙星的隐形眼镜相比,含加替沙星的隐形眼镜的物理性质有所下降。随着加替沙星浓度的增加,透氧性和润湿性降低,而抗菌性增加。LBL 涂层改善了隐形眼镜的润湿性和抗菌性,并延长了药物释放时间。双层镀膜镜片比单层镀膜镜片更能延长药物释放的持续时间。 图文摘要隐形眼镜上的聚左旋赖氨酸和卡拉胶双层镀膜
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Drug release and physical properties of double layers coated contact lenses using natural polymers

This study aims to develop contact lenses with improved drug-release duration time by layer-by-layer (LBL) coating with natural polymers on contact lenses containing the drug gatifloxacin. LBL coating was performed in single and double layers on contact lenses containing gatifloxaxin using natural polymers carrageenan and polylysine. The performance of contact lenses was evaluated based on various physical properties and antibacterial properties. As a result, contact lenses containing gatifloxacin have reduced physical properties compared to lenses without gatifloxacin. As the concentration of gatifloxacin increased, oxygen permeability and wettability decreased, and antibacterial properties increased. LBL coating improved the wettability and antibacterial properties of contact lenses and increased the drug-release duration. Double-layers coated lenses increased the duration of drug release more than single-coated lenses.

Graphic Abstract

Double layer-coating with poly-L-lysine and carrageenan on contact lenses

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Macromolecular Research
Macromolecular Research 工程技术-高分子科学
CiteScore
4.70
自引率
8.30%
发文量
100
审稿时长
1.3 months
期刊介绍: Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.
期刊最新文献
Biodegradable and antioxidant lignin-adsorbed polylactic acid microparticles for eco-friendly primary microparticles Discarded bamboo chopstick cellulose-based fibers for bio-based polybutylene succinate composite reinforcement Recent achievements in conjugated polymer-based gas sensors by side-chain engineering Antimicrobial polymer coatings on surfaces: preparation and activity Polymer-induced surface wrinkling and imine polymer-based doping of sol–gel zinc oxide in electrolyte-gated transistors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1