Samara Cardoso de Jesus, Guilherme Henrique Mendes Ribeiro, Hebert Cleiton Ferreira Souza, Alfredo Mauricio Batista de Paula, Lucyana Conceição Farias, André Luiz Sena Guimaraes and Sérgio Henrique Sousa Santos*,
{"title":"蝼蛄全粉能改善肥胖小鼠的血糖参数并调节致脂基因的表达","authors":"Samara Cardoso de Jesus, Guilherme Henrique Mendes Ribeiro, Hebert Cleiton Ferreira Souza, Alfredo Mauricio Batista de Paula, Lucyana Conceição Farias, André Luiz Sena Guimaraes and Sérgio Henrique Sousa Santos*, ","doi":"10.1021/acsfoodscitech.4c00013","DOIUrl":null,"url":null,"abstract":"<p >Obesity is a chronic illness that lowers quality of life; several dietary approaches have been considered as potential treatments. Due to its impact on regulating metabolism and weight, eating edible insects has become more popular among the available options. The objective of the current investigation was to assess the impact of wholemeal <i>Gryllus assimilis</i> (GA) powder as a dietary supplement on the regulation of genes in the adipose tissue and metabolic alterations in a mouse model of obesity. Several parameters were evaluated, including food intake, body weight, biochemical parameters, histological parameters, and adipose tissue mRNA expression. The main results showed that <i>G. assimilis</i> consumption modulates metabolic pathways and prevents hypertrophy in adipocytes while promoting a reduction in adipose tissue weight. In addition, glycemic parameters were improved, increasing insulin sensitivity and glucose tolerance. Thus, it can be said that eating black crickets enhanced the problems associated with obesity and effectively provided metabolic benefits. The results indicate that <i>G. assimilis</i> consumption may be a viable therapeutic strategy for preventing and treating obesity.</p>","PeriodicalId":72048,"journal":{"name":"ACS food science & technology","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsfoodscitech.4c00013","citationCount":"0","resultStr":"{\"title\":\"Gryllus assimilis Dietary Wholemeal Powder Improves Glycemic Parameters and Regulates the Expression of Lipogenic Genes in Obese Mice\",\"authors\":\"Samara Cardoso de Jesus, Guilherme Henrique Mendes Ribeiro, Hebert Cleiton Ferreira Souza, Alfredo Mauricio Batista de Paula, Lucyana Conceição Farias, André Luiz Sena Guimaraes and Sérgio Henrique Sousa Santos*, \",\"doi\":\"10.1021/acsfoodscitech.4c00013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Obesity is a chronic illness that lowers quality of life; several dietary approaches have been considered as potential treatments. Due to its impact on regulating metabolism and weight, eating edible insects has become more popular among the available options. The objective of the current investigation was to assess the impact of wholemeal <i>Gryllus assimilis</i> (GA) powder as a dietary supplement on the regulation of genes in the adipose tissue and metabolic alterations in a mouse model of obesity. Several parameters were evaluated, including food intake, body weight, biochemical parameters, histological parameters, and adipose tissue mRNA expression. The main results showed that <i>G. assimilis</i> consumption modulates metabolic pathways and prevents hypertrophy in adipocytes while promoting a reduction in adipose tissue weight. In addition, glycemic parameters were improved, increasing insulin sensitivity and glucose tolerance. Thus, it can be said that eating black crickets enhanced the problems associated with obesity and effectively provided metabolic benefits. The results indicate that <i>G. assimilis</i> consumption may be a viable therapeutic strategy for preventing and treating obesity.</p>\",\"PeriodicalId\":72048,\"journal\":{\"name\":\"ACS food science & technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.acs.org/doi/epdf/10.1021/acsfoodscitech.4c00013\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS food science & technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsfoodscitech.4c00013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS food science & technology","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsfoodscitech.4c00013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
肥胖症是一种降低生活质量的慢性疾病,有几种饮食方法被认为是潜在的治疗方法。由于食用昆虫对调节新陈代谢和体重的影响,食用昆虫已成为更受欢迎的选择。本次调查的目的是评估全麦蝼蛄(GA)粉作为膳食补充剂对肥胖小鼠模型中脂肪组织基因调控和代谢改变的影响。研究评估了多项参数,包括食物摄入量、体重、生化参数、组织学参数和脂肪组织 mRNA 表达。主要结果显示,食用 G. assimilis 可调节代谢途径,防止脂肪细胞肥大,同时促进脂肪组织重量的减轻。此外,血糖参数也得到了改善,提高了胰岛素敏感性和葡萄糖耐量。因此,可以说食用黑蟋蟀能改善与肥胖有关的问题,并有效提供代谢益处。研究结果表明,食用黑蟋蟀可能是预防和治疗肥胖症的一种可行的治疗策略。
Gryllus assimilis Dietary Wholemeal Powder Improves Glycemic Parameters and Regulates the Expression of Lipogenic Genes in Obese Mice
Obesity is a chronic illness that lowers quality of life; several dietary approaches have been considered as potential treatments. Due to its impact on regulating metabolism and weight, eating edible insects has become more popular among the available options. The objective of the current investigation was to assess the impact of wholemeal Gryllus assimilis (GA) powder as a dietary supplement on the regulation of genes in the adipose tissue and metabolic alterations in a mouse model of obesity. Several parameters were evaluated, including food intake, body weight, biochemical parameters, histological parameters, and adipose tissue mRNA expression. The main results showed that G. assimilis consumption modulates metabolic pathways and prevents hypertrophy in adipocytes while promoting a reduction in adipose tissue weight. In addition, glycemic parameters were improved, increasing insulin sensitivity and glucose tolerance. Thus, it can be said that eating black crickets enhanced the problems associated with obesity and effectively provided metabolic benefits. The results indicate that G. assimilis consumption may be a viable therapeutic strategy for preventing and treating obesity.