对 "呋喃缺陷LoVo细胞系中β-淀粉样蛋白前体蛋白的α-分泌酶分解:原激素转化酶7和崩解蛋白和金属蛋白酶ADAM10的参与 "的更正。

IF 4.2 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Neurochemistry Pub Date : 2024-07-07 DOI:10.1111/jnc.16177
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引用次数: 0

摘要

Lopez-Perez,E.、Zhang,Y.、Frank,S.J.、Creemers,J.、Seidah,N. 和 Checler,F. (2001),在呋喃缺陷的 LoVo 细胞系中,β 淀粉样蛋白前体蛋白的α-分泌酶裂解是连续的:原激素转化酶 7 和崩解金属蛋白酶 ADAM10 的参与。神经化学杂志》(Journal of Neurochemistry),76,1532-1539。https://doi.org/10.1046/j.1471-4159.2001.00180.xIt,我们注意到 "图 5c M 对照 "与 "图 5g M 对照 "相同,而 "图 5c M TAPI "与 "图 5g M TAPI "相同--它们似乎是重复的。在这组实验中,模拟、ADAM10 和 TACE 转染实验始终平行进行,并在同一块凝胶上充电。因此,模拟转染细胞(对照或 TAPI 处理)是 ADAM10 和 TACE 转染细胞的共同对照。为了清楚起见,在 5c 和 5g 中分离 ADAM10 或 TACE1 的数据时,重新排列了插图,模拟转染 M +/- TAPI 的泳道是两种实验条件的共同泳道。在 5d 和 5h 中,对照和 TAPI 条件下模拟转染细胞(黑条)的柱状图完全相同。这一量化结果证明,虽然对照组和 TAPI 模拟转染条件相同,但我们将凝胶一分为二,重新排列了凝胶。作者对投稿时没有提供这一解释表示歉意。
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Correction to “Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin and metalloprotease ADAM10”

Lopez-Perez, E., Zhang, Y., Frank, S.J., Creemers, J., Seidah, N. and Checler, F. (2001), Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: Involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10. Journal of Neurochemistry, 76, 1532–1539. https://doi.org/10.1046/j.1471-4159.2001.00180.x

It came to our attention that “Fig. 5c M Control” is the same as “Fig. 5g M Control” and “Fig. 5c M TAPI” is the same as “Fig. 5g M TAPI”—they appear to be duplicates. In this set of experiments, mock, ADAM10 and TACE transfection experiments were always done in parallel and charged on the same gel. Thus, the mock-transfected cells (either control or TAPI-treated) are the common control for both ADAM10- and TACE-transfected cells. When separating data for ADAM10 or TACE1 for clarity purpose in 5c and 5g, illustrations were rearranged and the mock-transfected M +/− TAPI lanes were common for the two experimental conditions. This is illustrated by the identical bar graphs in 5d and 5h for mock-transfected (black bars) cells in control and TAPI conditions. This quantification supports the fact that we rearranged the gel by splitting it in two although keeping common control and TAPI mock-transfected conditions. The authors apologize for not providing this explanation when submitting the article.

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来源期刊
Journal of Neurochemistry
Journal of Neurochemistry 医学-神经科学
CiteScore
9.30
自引率
2.10%
发文量
181
审稿时长
2.2 months
期刊介绍: Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.
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