妊娠诱发高血压的 DNA 甲基化状况:进展与挑战。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reproductive Biology and Endocrinology Pub Date : 2024-07-08 DOI:10.1186/s12958-024-01248-0
Fengying Deng, Jiahui Lei, Junlan Qiu, Chenxuan Zhao, Xietong Wang, Min Li, Miao Sun, Meihua Zhang, Qinqin Gao
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引用次数: 0

摘要

妊娠高血压(PIH),尤其是子痫前期(PE),是一种常见的妊娠并发症。这种情况对母亲和胎儿的健康都有很大风险。新的证据表明,表观遗传修饰,尤其是 DNA 甲基化,可能在引发 PIH 最早的病理生理学过程中发挥作用。本文介绍了 DNA 甲基化与胎盘滋养层功能的关系,与胎盘微环境、胎盘血管系统、母体血液和血管功能相关的基因,PIH 发病和进展过程中脐带血和血管功能的异常,以及 PIH 后代(母体、胎儿和后代)DNA 甲基化的变化。我们还将探讨基于 DNA 甲基化的 PIH 早期检测、诊断和潜在治疗策略的最新研究。这将使 DNA 甲基化研究领域继续增进我们对 PIH 基因表观遗传调控的了解,并确定潜在的治疗目标。
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DNA methylation landscape in pregnancy-induced hypertension: progress and challenges.

Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the health of both the mother and the fetus. Emerging evidence suggests that epigenetic modifications, particularly DNA methylation, may play a role in initiating the earliest pathophysiology of PIH. This article describes the relationship between DNA methylation and placental trophoblast function, genes associated with the placental microenvironment, the placental vascular system, and maternal blood and vascular function, abnormalities of umbilical cord blood and vascular function in the onset and progression of PIH, as well as changes in DNA methylation in the progeny of PIH, in terms of maternal, fetal, and offspring. We also explore the latest research on DNA methylation-based early detection, diagnosis and potential therapeutic strategies for PIH. This will enable the field of DNA methylation research to continue to enhance our understanding of the epigenetic regulation of PIH genes and identify potential therapeutic targets.

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来源期刊
Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.30%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.
期刊最新文献
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