Megan N Brobst, Bailey A Abi-Nader, Sarah J Blasczynski, Munashe Chigerwe
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Agreement between the CGMS and the chemistry analyzer was determined by Bland-Altman plots. The analytical and clinical accuracy of the CGMS was determined using the International Organization for Standardization (ISO) 15197:2013 criteria and the Parkes error grid analysis.</p><p><strong>Results: </strong>In goats, the CGMS overestimated glucose concentrations during the hypoglycemic, normoglycemia, and hyperglycemia treatments. In calves, the CGMS underestimated glucose concentrations during the hypoglycemic treatment but overestimated glucose concentrations in normoglycemia and hyperglycemic treatments. The CGMS met the ISO clinical accuracy criteria for goats and calves, with > 99% of the glucose measurements in zones A and B of the Parkes grid. However, the CGMS did not meet the ISO 15197:2013 criteria for analytical accuracy.</p><p><strong>Clinical relevance: </strong>The CGMS evaluated in our study only met the ISO 15197:2013 clinical accuracy criteria, not the analytical accuracy. Therefore, the device might be considered for clinical use.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of a continuous glucose monitoring system in healthy dairy calves and adult goats.\",\"authors\":\"Megan N Brobst, Bailey A Abi-Nader, Sarah J Blasczynski, Munashe Chigerwe\",\"doi\":\"10.2460/ajvr.24.03.0076\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the accuracy of a continuous glucose monitoring system (CGMS) device by comparing glucose concentrations measured over time as determined by the CGMS to those of the chemistry analyzer (reference method).</p><p><strong>Animals: </strong>7 healthy goats and 7 dairy calves.</p><p><strong>Methods: </strong>A randomized, crossover design with 3 treatments: control, hypoglycemia, and hyperglycemia. 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引用次数: 0
摘要
目的:通过比较连续葡萄糖监测系统(CGMS)和化学分析仪(参考方法)测定的葡萄糖浓度,确定连续葡萄糖监测系统(CGMS)的准确性:通过比较连续葡萄糖监测系统(CGMS)与化学分析仪(参考方法)测定的葡萄糖浓度,确定连续葡萄糖监测系统(CGMS)设备的准确性:方法:采用随机交叉设计,3 种处理方法:对照组、低血糖组和高血糖组。CGMS装置应用于颈部。分别用胰岛素和异丙嗪诱导低血糖和高血糖。分别在 0 小时(治疗前)、2 小时、4 小时、6 小时、8 小时、10 小时和 12 小时用 CGMS 化学分析仪、护理点血糖仪和重症监护室机器测量血糖浓度。CGMS 与化学分析仪之间的一致性由 Bland-Altman 图确定。采用国际标准化组织 (ISO) 15197:2013 标准和 Parkes 误差网格分析法确定 CGMS 的分析和临床准确性:结果:在低血糖、正常血糖和高血糖处理过程中,CGMS 高估了山羊的血糖浓度。在犊牛身上,CGMS 低估了低血糖治疗时的血糖浓度,但高估了正常血糖和高血糖治疗时的血糖浓度。对于山羊和犊牛,CGMS 符合 ISO 临床准确度标准,99% 以上的葡萄糖测量值位于 Parkes 网格的 A 区和 B 区。但是,CGMS 的分析准确度不符合 ISO 15197:2013 标准:我们研究中评估的 CGMS 只符合 ISO 15197:2013 临床准确性标准,不符合分析准确性标准。因此,该设备可考虑用于临床。
Evaluation of a continuous glucose monitoring system in healthy dairy calves and adult goats.
Objective: To determine the accuracy of a continuous glucose monitoring system (CGMS) device by comparing glucose concentrations measured over time as determined by the CGMS to those of the chemistry analyzer (reference method).
Animals: 7 healthy goats and 7 dairy calves.
Methods: A randomized, crossover design with 3 treatments: control, hypoglycemia, and hyperglycemia. The CGMS device was applied to the neck. Hypoglycemia and hyperglycemia were induced by insulin and xylazine, respectively. Glucose concentrations were measured by the chemistry analyzer CGMS, point-of-care glucometer, and intensive care unit machine at 0 (before treatment), 2, 4, 6, 8, 10, and 12 hours. Agreement between the CGMS and the chemistry analyzer was determined by Bland-Altman plots. The analytical and clinical accuracy of the CGMS was determined using the International Organization for Standardization (ISO) 15197:2013 criteria and the Parkes error grid analysis.
Results: In goats, the CGMS overestimated glucose concentrations during the hypoglycemic, normoglycemia, and hyperglycemia treatments. In calves, the CGMS underestimated glucose concentrations during the hypoglycemic treatment but overestimated glucose concentrations in normoglycemia and hyperglycemic treatments. The CGMS met the ISO clinical accuracy criteria for goats and calves, with > 99% of the glucose measurements in zones A and B of the Parkes grid. However, the CGMS did not meet the ISO 15197:2013 criteria for analytical accuracy.
Clinical relevance: The CGMS evaluated in our study only met the ISO 15197:2013 clinical accuracy criteria, not the analytical accuracy. Therefore, the device might be considered for clinical use.
期刊介绍:
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.