产前接触持久性有机污染物混合物对智力发育的影响。

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES International journal of hygiene and environmental health Pub Date : 2024-07-08 DOI:10.1016/j.ijheh.2024.114422
Christophe Barrea , Patrice Dufour , Pirard Catherine , Corinne Charlier , Fanny Brevers , Laurence Rousselle , Anne-Simone Parent
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引用次数: 0

摘要

目的:有确凿的实验证据表明,几种干扰内分泌的化学品(EDCs)具有神经行为毒性。然而,产前暴露与儿童认知发展之间的关联证据并不一致。此外,人们通常对有毒物质进行逐一分析,而不考虑其综合影响。我们在此研究了产前接触持久性有机污染物(POPs)混合物对学龄前儿童智力的影响,并将其影响与文献中描述的影响进行了比较:方法:在一个纵向队列中纳入了 62 名儿童。测量了脐带血中的四种有机氯农药、四种多氯联苯和七种全氟化合物。我们使用韦氏学前和小学智力量表第四版(WPPSI-IV)对 6 岁儿童的智力进行了评估。我们使用主成分法(PCA)和加权量子和(WQS)回归法研究了持久性有机污染物混合物与认知能力之间的关联,并将性别差异考虑在内:对男孩和女孩一起进行分析时未发现负相关。在性别分层分析中,观察到接触持久性有机污染物混合物最多的男孩的全量表智商(FSIQ)和流体推理指数(FRI)较低。只有女孩的 WQS 指数的增加与言语理解指数(VCI)的降低有关。使用 WQS 和 PCA 模型没有发现其他负相关关系:我们的研究表明,产前暴露于持久性有机污染物混合物与特定性别的认知水平之间存在有害关联,从而澄清了文献中描述的一些趋势。
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Impact of antenatal exposure to a mixture of persistent organic pollutants on intellectual development

Objective

Strong experimental evidence exists that several endocrine disrupting chemicals (EDCs) have neurobehavioral toxicity. However, evidence of associations between prenatal exposure and child's cognitive development is inconsistent. Moreover, toxicants are generally analyzed one by one without considering aggregate effects. We examined here the impact of a prenatal exposure to a mixture of persistent organic pollutants (POPs) on intellectual abilities in preschool children, and compared their effects to those described in the literature.

Methods

Sixty-two children were included in a longitudinal cohort. Four organochlorine pesticides, four polychlorinated biphenyls (PCBs) and seven perfluorinated compounds (PFCs) were measured in cord blood. Intellectual abilities were assessed at 6 years of age using the Wechsler Preschool and Primary Scale of Intelligence 4th ed. (WPPSI-IV). We examined the associations between a mixture of POPs and cognitive performances using principal components approach (PCA) and weighted quantile sum (WQS) regression taking sex difference into account.

Results

No negative correlation was found when analyses were performed on boys and girls together. In sex-stratified analyses, lower scores in full scale intelligence quotient (FSIQ) and fluid reasoning index (FRI) were observed in boys most exposed to a mixture of POPs. Increase of the WQS index was also associated with lower verbal comprehension index (VCI) scores in girls only. No other negative correlation was found using both WQS and PCA models.

Conclusion

Our study suggests deleterious associations between antenatal exposure to a mixture of POPs and sex-specific cognitive level, clarifying some trends described in the literature.

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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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