与超重或肥胖成人间歇性禁食有关的不良事件概况:随机对照试验的系统回顾和荟萃分析。

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Nutrition Journal Pub Date : 2024-07-10 DOI:10.1186/s12937-024-00975-9
Fan Zhong, Ting Zhu, Xingyi Jin, Xiangjun Chen, Ruipeng Wu, Li Shao, Shaokang Wang
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引用次数: 0

摘要

背景:尽管间歇性禁食广泛用于超重或肥胖症患者,但全面总结间歇性禁食不良事件(AEs)概况的证据却很少:我们搜索了主要的电子数据库和注册网站,以确定符合条件的随机对照试验(RCT),这些试验比较了间歇性禁食组和对照组。采用固定效应模型进行直接荟萃分析,以汇集常见AEs和辍学的风险差异。研究质量采用 Jadad 量表进行评估。进行了预先指定的亚组和敏感性分析,以探讨潜在的异质性:共纳入了 15 项 RCT,涉及 1,365 名成人。研究结果显示,在疲劳风险率[0%,95% 置信区间(CI):-1% 至 2%;P = 0.61]、头痛风险率[0%,95%CI:-1% 至 2%;P = 0.86]和辍学风险率[1%,95%CI:-2% 至 4%;P = 0.51]方面,IF 和对照组之间没有显著差异。然而,在不限制进食时间的单用 IF 亚组中,出现头晕的风险较高[3%,95%CI:-0% 至 6%;P = 0.08]:这项荟萃分析表明,在受超重或肥胖影响的成年患者中,中性食物与发生 AEs 的更大风险无关。要确定这些 AEs 的情况,还需要进行更多大规模的 RCT 研究,根据主要的混杂因素进行分层,并评估各种 IF 方案的长期效果。
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Adverse events profile associated with intermittent fasting in adults with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials.

Background: There is little evidence to comprehensively summarize the adverse events (AEs) profile of intermittent fasting (IF) despite its widespread use in patients with overweight or obesity.

Methods: We searched the main electronic databases and registry websites to identify eligible randomized controlled trials (RCTs) comparing IF versus control groups. A direct meta-analysis using a fixed-effect model was conducted to pool the risk differences regarding common AEs and dropouts. Study quality was assessed by using the Jadad scale. Pre-specified subgroup and sensitivity analyses were conducted to explore potential heterogeneity.

Results: A total of 15 RCTs involving 1,365 adult individuals were included. Findings did not show a significant difference between IF and Control in risk rate of fatigue [0%, 95% confidence interval (CI), -1% to 2%; P = 0.61], headache [0%, 95%CI: -1% to 2%; P = 0.86] and dropout [1%, 95%CI: -2% to 4%; P = 0.51]. However, a numerically higher risk of dizziness was noted among the IF alone subgroup with non-early time restricted eating [3%, 95%CI: -0% to 6%; P = 0.08].

Conclusions: This meta-analysis suggested that IF was not associated with a greater risk of AEs in adult patients affected by overweight or obesity. Additional large-scale RCTs stratified by key confounders and designed to evaluate the long-term effects of various IF regimens are needed to ascertain these AEs profile.

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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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