评估双点对比增强磁共振成像在区分脑肿瘤与非肿瘤组织中的作用的前瞻性研究:一项磁共振/PET研究。

IF 0.4 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Indian Journal of Nuclear Medicine Pub Date : 2024-03-01 Epub Date: 2024-05-29 DOI:10.4103/ijnm.ijnm_103_23
Sandhya Mangalore, Guddanti Venkata Naga Pradeep, Venkatesh K S Murthy, Pawan Bairwa, Pardeep Kumar, Jitender Saini, Chandrajit Prasad, Nishanth Sadashiva, Manish Beniwal, Vani Santosh
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引用次数: 0

摘要

背景和目的:胶质瘤的后续成像对于寻找残留或复发以及区分胶质瘤和非肿瘤组织至关重要。正电子发射断层扫描(PET)-磁共振成像(MRI)是此类病例中解决问题的工具。与作为金标准的 PET-MRI 相比,我们研究了双点对比(DPC)增强 MRI 在区分肿瘤组织和非肿瘤组织方面的作用:研究获得了机构伦理委员会的批准,并征得了所有患者的同意。作为 PET-MRI 研究的一部分,我们对前来随访的胶质瘤病例进行了前瞻性的即时和 75 分钟延迟对比 MRI 检查。使用即时和 75 分钟延迟对比图像获得减影图像。将彩色编码减影图像与 PET-MRI 图像进行比较。将 75 分钟延迟对比 MRI 和灰度反转弥散加权成像(DWI)图像与 PET 衰减校正图像进行比较:我们的研究包括 23 个使用不同放射性核素进行 PET MRI 的病例。总体而言,我们发现(20/20 ~ 100%)增强肿瘤病例存在 PET-DPC 相关性。有两例(DOPA 和氟脱氧葡萄糖)由于是非增强型低级别胶质瘤,另一例是具有内在 T1 高密度的黑色素瘤,因此无法使用 DPC 技术。在排除出血病例后,17/19(约89.4%)例患者的 DWI-PET 相互关联,14/18(约 77.7%)例患者的灌注加权成像(PWI)-PET 动态易感对比(DSC)/ASL 相互关联:结论:DPC MRI 与 PET MRI 在区分肿瘤组织和非肿瘤组织方面显示出良好的相关性。在没有 PET MRI 的周边医院,DPC MRI 可作为 PET MRI 的潜在替代方法。不过,DPC 技术在低级别非增强型胶质瘤中的应用有限。
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Prospective Study to Evaluate the Role of Dual Point Contrast-enhanced Magnetic Resonance Imaging in Differentiation of Brain Tumoral from Nontumoral Tissue: A Magnetic Resonance/PET Study.

Background and purpose: Follow-up imaging of gliomas is crucial to look for residual or recurrence and to differentiate them from nontumoral tissue. Positron emission tomography (PET)-magnetic resonance imaging (MRI) is the problem-solving tool in such cases. We investigated the role of dual point contrast (DPC)-enhanced MRI to discriminate tumoral from the nontumoral tissue compared to PET-MRI taken as the gold standard.

Materials and methods: The institutional ethics committee approved the study, and consent was obtained from all the patients included in the study. We prospectively did immediate and 75-min delayed contrast MRI in glioma cases who came for follow-up as a part of PET-MRI study in our institute. Subtracted images were obtained using immediate and 75-min delayed contrast images. Color-coded subtracted images were compared with PET-MRI images. 75-min delayed contrast MRI and diffusion-weighted imaging (DWI) images with Gray Scale inversion were compared with PET attenuation-corrected images.

Results: We included 23 PET MRI cases done with different radiotracers in our study. Overall, we found PET-DPC correlation in (20/20 ~ 100%) cases of enhancing tumors. In two cases (DOPA and fluorodeoxyglucose), since they were nonenhancing low-grade gliomas and the other one was melanoma with intrinsic T1 hyperintensity and the DPC technique could not be used. DWI-PET correlated in 17/19 (~89.4%) cases, and perfusion-weighted imaging (PWI)-PET dynamic susceptibility contrast (DSC)/ASL correlated in 14/18 (~77.7%) cases after cases with hemorrhage were excluded.

Conclusion: DPC MRI showed a good correlation with PET MRI in discriminating tumoral from the nontumoral tissue. DPC MRI can act as a potential alternative to PET MRI in peripheral hospitals where PET is not available. However, the DPC technique is limited in low-grade nonenhancing gliomas.

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来源期刊
Indian Journal of Nuclear Medicine
Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.70
自引率
0.00%
发文量
46
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