超声波辅助壳聚糖聚合物稳定银纳米粒子的绿色合成:腹泻治疗应用研究

IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Science: Advanced Materials and Devices Pub Date : 2024-06-24 DOI:10.1016/j.jsamd.2024.100759
Lin Wang , Lei Qiao , Yuzhi Liu , Fengyue Li , Attalla F. El-kott , Mohammed A. AlShehri , Kareem Morsy
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引用次数: 0

摘要

目前的研究旨在利用蓍草花的水提取物,通过生物途径制备壳聚糖封端银纳米粒子。通过各种光谱技术对生物合成的银纳米粒子/壳聚糖(Ag NPs@CHI)进行了表征。通过紫外可见光谱记录的 545 纳米波长处的单个宽峰,初步确定了壳聚糖上银纳米粒子的形成。通过 TEM 和 SEM 照片验证了 Ag NPs@CHI 的多分散性、球形和纳米尺寸。XRD 分析证实了制备的 Ag NPs@CHI 的纯度和结晶性质。在体内,Ag NPs@CHI 减少了结肠和回肠中炎症细胞的存在,降低了 IL-17A、IL-1β、IL-6 和 TNF-α 的水平,提高了结肠组织中 IL-10 和 IL-4 的水平,促进了乙酸盐和丙酸盐的产生。研究结果表明,Ag NPs@CHI具有促进肠道结构恢复、降低炎性细胞因子水平和提高短链脂肪酸(SCFA)水平的潜力。我们的研究表明,银纳米粒子@CHI可通过上调Claudin-1和Occludin的表达来保护肠道屏障。此外,银纳米粒子还能抑制 MAPK 信号通路,从而改善炎症状况。在完成临床试验后,这些新型纳米粒子有望成为治疗人类腹泻的新疗法。
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Ultrasound assisted green synthesis of silver nanoparticles stabilized by chitosan polymers: Investigation of its therapeutic application in diarrhea

The current investigation aims to study the bio route preparation of chitosan capped-silver nanoparticles using aqueous flower extract of the Achillea ptarmica plant. The biosynthesized silver nanoparticles/chitosan (Ag NPs@CHI) were characterized by various spectroscopic techniques. The creation of Ag nanoparticles over the chitosan was initially determined by the presence of a single broad peak at 545 nm that was recorded by the UV–Vis spectrum. The presence of poly-dispersity, spherical shape and nanosizes in the Ag NPs@CHI were verified by the TEM and SEM pictures. The purity and crystalline nature of the prepared Ag NPs@CHI were confirmed by XRD analysis. In vivo, Ag NPs@CHI decreased the inflammatory cells presence in the colon and ileum, lowered the levels of IL-17A, IL-1β, IL-6, and TNF-α, raised the levels of IL-10 and IL-4 in colon tissues, enhanced acetate and propionate production. The findings revealed that Ag NPs@CHI have the potential to boost intestinal structure restoration, decrease levels of inflammatory cytokines and enhance short-chain fatty acid (SCFA) levels. Our research demonstrated that Ag NPs@CHI can safeguard the intestinal barrier by upregulating the expression of Claudin-1 and Occludin. Furthermore, silver nanoparticles suppressed the MAPK signaling pathway to ameliorate the inflammatory condition. Following the completion of clinical trials, these novel nanoparticles could serve as a promising new treatment for diarrhea in humans.

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来源期刊
Journal of Science: Advanced Materials and Devices
Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials
CiteScore
11.90
自引率
2.50%
发文量
88
审稿时长
47 days
期刊介绍: In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.
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